Results 11 to 20 of about 1,392,696 (262)

Synthesis of C-glycosyl phosphonate derivatives of 4-amino-4-deoxy-α-ʟ-arabinose

Beilstein Journal of Organic Chemistry, 2020
The incorporation of basic substituents into the structurally conserved domains of cell wall lipopolysaccharides has been identified as a major mechanism contributing to antimicrobial resistance of Gram-negative pathogenic bacteria.
Lukáš Kerner, Paul Kosma
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Synthesis of monophosphorylated lipid A precursors using 2-naphthylmethyl ether as a protecting group

Beilstein Journal of Organic Chemistry, 2020
Lipid A, the hydrophobic domain of lipopolysaccharide (LPS), is a strong immunostimulator and therefore a valuable target for the development of novel immunomodulators.
Jundi Xue, Ziyi Han, Gen Li, Khalisha A. Emmanuel, Cynthia L. McManus, Qiang Sui, Dongmian Ge, Qi Gao, Li Cai   +8 more
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Lipid Simulations: A Perspective on Lipids in Action [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
In this article, we provide an overview of lipid simulations, describing how a computer can be used as a laboratory for lipid research. We briefly discuss the methodology of lipid simulations followed by a number of topical applications that show the benefit of computer modeling for complementing experiments. In particular, we show examples of cases in
Vattulainen Ilpo, Rog Thomasz
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The Xanthomonas RaxH-RaxR Two-Component Regulatory System Is Orthologous to the Zinc-Responsive Pseudomonas ColS-ColR System

Microorganisms, 2021
Genome sequence comparisons to infer likely gene functions require accurate ortholog assignments. In Pseudomonas spp., the sensor-regulator ColS-ColR two-component regulatory system responds to zinc and other metals to control certain membrane-related ...
Valley Stewart, Pamela C. Ronald
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Lipid Nanotechnology [PDF]

International Journal of Molecular Sciences, 2013
Nanotechnology is a multidisciplinary field that covers a vast and diverse array of devices and machines derived from engineering, physics, materials science, chemistry and biology. These devices have found applications in biomedical sciences, such as targeted drug delivery, bio-imaging, sensing and diagnosis of pathologies at early stages.
S. Mashaghi (Samaneh), T. Jadidi, G.H. Koenderink (Gijsje), A. Mashaghi (Alireza)   +3 more
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The Serine Hydrolase ABHD6 Is a Critical Regulator of the Metabolic Syndrome

Cell Reports, 2013
The serine hydrolase α/β hydrolase domain 6 (ABHD6) has recently been implicated as a key lipase for the endocannabinoid 2-arachidonylglycerol (2-AG) in the brain.
Gwynneth Thomas, Jenna L. Betters, Caleb C. Lord, Amanda L. Brown, Stephanie Marshall, Daniel Ferguson, Janet Sawyer, Matthew A. Davis, John T. Melchior, Lawrence C. Blume, Allyn C. Howlett, Pavlina T. Ivanova, Stephen B. Milne, David S. Myers, Irina Mrak, Vera Leber, Christoph Heier, Ulrike Taschler, Jacqueline L. Blankman, Benjamin F. Cravatt, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, Robert Zimmermann, H. Alex Brown, J. Mark Brown   +25 more
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CGI-58/ABHD5 is phosphorylated on Ser239 by protein kinase A: control of subcellular localization[S]

Journal of Lipid Research, 2015
CGI-58/ABHD5 coactivates adipose triglyceride lipase (ATGL). In adipocytes, CGI-58 binds to perilipin 1A on lipid droplets under basal conditions, preventing interaction with ATGL. Upon activation of protein kinase A (PKA), perilipin 1A is phosphorylated
Anita Sahu-Osen, Gabriela Montero-Moran, Matthias Schittmayer, Katarina Fritz, Anna Dinh, Yu-Fang Chang, Derek McMahon, Andras Boeszoermenyi, Irina Cornaciu, Deanna Russell, Monika Oberer, George M. Carman, Ruth Birner-Gruenberger, Dawn L. Brasaemle   +13 more
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Physicochemical characterization of biological and synthetic forms of two lipid A-based TLR4 agonists

Heliyon, 2023
Toll-like receptor (TLR) agonists are recognized as potential immune-enhancing adjuvants and are included in several licensed vaccines. Monophosphoryl lipid A (MPL®, GlaxoSmithKline) is one such TLR4 agonist that has been approved for use in human ...
Gang Hu, David J. Varisco, Sayan Das, C. Russell Middaugh, Francesca Gardner, Robert K. Ernst, Wendy L. Picking, William D. Picking   +7 more
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Interactions between lipid source and vitamin A on broiler performance, blood parameters, fat and protein deposition rate, and bone development

Poultry Science, 2021
A total of 2622 male broilers were distributed in a 2 × 5 factorial design, using 2 lipid sources (soybean oil and palm fat), 5 levels of vitamin A supplementation (0, 3,000, 6,000, 12,000, and 24,000 IU kg−1), with 10 replicates, and also 1 control diet
V.D.L. Savaris, C. Souza, L. Wachholz, J. Broch, C. Polese, P.L.O. Carvalho, P.C. Pozza, C. Eyng, R.V. Nunes   +8 more
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Lipids and lipid metabolism in the eye [PDF]

Journal of Lipid Research, 2009
The vertebrate eye is a complex sensory organ consisting of multiple, distinct tissues, each having its own unique biochemical composition, structure, and physiological function. Key among these are the retina, lens, and cornea, working in concert to bring photons of light into the eye, focus them correctly on the retina, and convert their energy into ...
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