Results 131 to 140 of about 3,316,815 (349)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Light/dark cycling causes delayed lipid accumulation and increased photoperiod-based biomass yield by altering metabolic flux in oleaginous Chlamydomonas sp.

Biotechnology for Biofuels, 2019
Background Light/dark cycling is an inevitable outdoor culture condition for microalgal biofuel production; however, the influence of this cycling on cellular lipid production has not been clearly established.
Yuichi Kato, Yusuke Fujihara, Christopher J. Vavricka, Jo-Shu Chang, Tomohisa Hasunuma, Akihiko Kondo   +5 more
doaj   +1 more source

Freely Available Tool (FAT) for automated quantification of lipid droplets in stained cells [PDF]

, 2017
In this study, wepropose an automatic procedure for digital image processing. Wedescribe a method that can efficiently quantify and characterizelipid droplets distributions in different cell types in culture.Prospectively, the lipid droplets detection ...
Bustos, Diego Martin, del Veliz, Samanta, Frontini López, Yesica Romina, Gojanovich, Aldana Daniela, Masone, Diego Fernando, Uhart, Marina   +5 more
core  

Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts

, 2020
A comprehensive characterization of the lipidome from limited starting material remains very challenging. Here we report a high-sensitivity lipidomics workflow based on nanoflow liquid chromatography and trapped ion mobility spectrometry (TIMS).
Barsch, A., Brunner, A., Mann, M., Meier, F., Meitei, N., Meyer, S., Schweiger-Hufnagel, U., Sulek, K., Vasilopoulou, C.   +8 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effect of plant-based feed ingredients on osmoregulation in the Atlantic salmon lens [PDF]

, 2010
Lenses of adult Atlantic salmon fed with a plant oil and plant protein-based diet (plant diet) were compared to lenses of fish fed a diet based on traditional marine ingredients (marine diet) with respect to biochemical composition and functionality ex ...
Baslow, Bell, Bell, Bell, Bjerkås, Bjerkås, Bjerkås, Bjerkås, Breck, Breck, Breck, Breck, Brodtkorb, Chan, Christiane Tröβe, Delamere, Duston, Hargis, Hawse, Iwata, Jeremy D. Rhodes, Jobling, Jordal, Julie Sanderson, Kantorow, Lu, Menzies, Mizuno, Ng, Nilsen, Olav Breck, Rune Waagbø, Sneddon, Sutherland, Tacon, Toivonen, Torstensen, Torstensen, Torstensen, Tröβe, Tröβe, Turchini, Untergasser, Ursini, Vandesompele, Vemuri, Virtanen, Waagbø, Waagbø, Waagbø, Wall, Yeagle, Zhang   +52 more
core   +1 more source

Effects of sodium bicarbonate on cell growth, lipid accumulation, and morphology of Chlorella vulgaris

Microbial Cell Factories, 2018
BackgroundLow concentration NaHCO3 (ca. 12 mM) had been demonstrated to be an excellent carbon source for industrially important green alga Chlorella vulgaris and high concentration NaHCO3 (e.g.
Jingya Li, Changhao Li, C. Lan, Dankui Liao   +3 more
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Ganoderma lucidum Spore Powder Alleviates Metabolic-Associated Fatty Liver Disease by Improving Lipid Accumulation and Oxidative Stress via Autophagy

Antioxidants
Lipid accumulation and oxidative stress, which could be improved by autophagy, are the “hits” of metabolic-associated fatty liver disease (MAFLD). Ganoderma lucidum spore powder (GLSP) has the effect of improving liver function.
Yuxuan Zhang, Jiali Zhou, Lan Yang, Hang Xiao, Dongbo Liu, Xincong Kang   +5 more
doaj   +1 more source

Renal Lipid Accumulation in Human Obesity

The FASEB Journal, 2013
In obesity and the metabolic syndrome, lipid accumulation in several non‐adipose tissues has been implicated in the pathogenesis of tissue and organ dysfunction. Whether obesity is associated with lipid accumulation in the human kidney remains uncertain.
Ion Alexandru Bobulescu, Tara Rosenthal, Hillary Thompson, Khashayar Sakhaee, Orson W Moe   +4 more
openaire   +1 more source