Results 111 to 120 of about 557,479 (308)

Ganoderma lucidum Spore Powder Alleviates Metabolic-Associated Fatty Liver Disease by Improving Lipid Accumulation and Oxidative Stress via Autophagy

Antioxidants
Lipid accumulation and oxidative stress, which could be improved by autophagy, are the “hits” of metabolic-associated fatty liver disease (MAFLD). Ganoderma lucidum spore powder (GLSP) has the effect of improving liver function.
Yuxuan Zhang, Jiali Zhou, Lan Yang, Hang Xiao, Dongbo Liu, Xincong Kang   +5 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity.

, 2020
Background: Elucidation of lipid metabolism and accumulation mechanisms is of paramount importance to understanding obesity and unveiling therapeutic targets.
Garten, A., Yang, Zuqin, Blüher, Matthias, Lemke, J., Schiller, Jürgen, Yang, Z., Dannenberger, Dirk, Lin, C., Çakır, Mehmet Volkan, M. Volkan Çakir, Nono Nankam, P., Chen-Ching Lin, Rolle-Kampczyk, Ulrike, Ulrike Rolle-Kampczyk, Kelso, Janet, Garten, Antje, Akhil, V., Johannes R. Lemke, Janet Kelso, Rolle-Kampczyk, U., Le Duc, D. ; https://orcid.org/, Grunewald, S., Velluva, A. ; https://orcid.org/, Nono Nankam, P.A., Grunewald, Sonja, Çakir, M., Simon, J.C., Blüher, M., Zuqin Yang, Jürgen Schiller, Antje Garten, Matthias Blüher, Yulia Popkova, Andreas Dietz, Popkova, Y., Velluva Akhil, Kelso, J., Dannenberger, D., Schöneberg, T., Akhil, Velluva, Schöneberg, Torsten, Diana Le Duc, Le Duc, D., Dirk Dannenberger, Dietz, Andreas, von Bergen, M., Lin, C.C., Lemke, J.R., Simon, Jan-Christoph, Nono Nankam, Pamela Arielle, Simon, J., Schiller, J., Pamela Arielle Nono Nankam, Jan-Christoph Simon, Çakir, M.V., Lemke, Johannes R., von Bergen, Martin, Sonja Grunewald, Lin, Chen-Ching, Popkova, Yulia, Dietz, A., Torsten Schöneberg, Le Duc, Diana, Martin von Bergen   +63 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Clusterin deficiency induces lipid accumulation and tissue damage in kidney

, 2018
Clusterin is a secretory glycoprotein that is involved in multiple physiopathological processes, including lipid metabolism. Previous studies have shown that clusterin prevents hepatic lipid accumulation via suppression of sterol regulatory element ...
Young Kyung Bae, Jae-Ryong Kim, Yong-Woon Kim, Ji-Eun Kim, Jong-Yeon Kim, In-Hwan Song, So-Young Park, Yongwook Dan, In-Kyu Lee, Seung-Soon Im, Jung-Yoon Heo, Kyu Hyang Cho, Kwang-Hyeon Liu   +12 more
core   +1 more source

Golgi condensation causes intestinal lipid accumulation through HIF-1α-mediated GM130 ubiquitination by NEDD4

Experimental and Molecular Medicine
The breakdown of Golgi proteins disrupts lipid trafficking, leading to lipid accumulation in the small intestine. However, the causal mechanism of the effects of Golgi protein degradation on the Golgi structure related to lipid trafficking in the small ...
Hyunsoo Kim, Channy Park, Xiaofan Wei, Arun Chhetri, Laxman Manandhar, Gyuho Jang, Jaetaek Hwang, Batchingis Chinbold, Chagtsalmaa Chuluunbaatar, Hyug Moo Kwon, Raekil Park   +10 more
doaj   +1 more source

Growth kinetics, fatty acid composition and metabolic activity changes of Crypthecodinium cohnii under different nitrogen source and concentration

AMB Express, 2017
The effect of varying concentrations of the nitrogen source on the growth kinetics, lipid accumulation, lipid and DHA productivity, and fatty acid composition of C. cohnii was elucidated. Growth of C.
Waseem Safdar, Muhammad Shamoon, Xinyi Zan, Junaid Haider, Hafiz Rizwan Sharif, Muhammad Shoaib, Yuanda Song   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Evaluating the effect of acetic acid, furfural and catechol on the growth and lipid accumulation of Trichosporon fermentans by response surface methodology

, 2012
The effect of combination of acetic acid, furfural and catechol on the growth and lipid accumulation of oleaginous yeast Trichosporon fermentans was systematically studied by response surface methodology (RSM).
Wen, Peng, Lou, Wen-yong, Zong, Min-hua, Huang, Chao, Wu, Hong   +4 more
core   +1 more source

Estradiol Determine Liver Lipid Deposition in Ratsfed Standard Diets Unbalanced with Excess Lipid or Protein

, 2020
The ingestion of excess fat often produces an increased body weight, because of higher adiposity and accumulation of fat in the liver. However, modulation of diet energy partition may affect differently the body metabolic responses and the extent of ...
Marià, Alemany, Laia, Oliva, Xavier, Remesar, José-Antonio, Fernández-López   +3 more
core   +1 more source