Results 101 to 110 of about 1,939,990 (302)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Calcium deposits in the perineurium and their relation to lipid accumulation

Journal of the Neurological Sciences, 1979
Calcification of the perineurium in sural nerves occurs in human adults. Deposits of calcium salts can be found focally in the middle and outer layers of the perineurium. Evidence indicates that this calcification is related to nerve fibre breakdown and to the local presence of lipids in the perineurium.
Lis, J.M.J. van, Jennekens, F.G.I., Veldman, H.   +2 more
openaire   +3 more sources

Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome.

, 2009
We evaluated the role of sterol-regulatory element binding protein (SREBP)-1c/peroxisome proliferator activated receptor- * (PPAR * ) pathway on heart lipotoxicity in patients with metabolic syndrome (MS) and aortic stenosis (AS).
SINISCALCHI N., CACCIAPUOTI, Federico, DI FILIPPO, Clara, BARBIERI, Michelangela, ROSSI, Francesco, PAOLISSO, Giuseppe, D'AMICO, Michele, PORTOGHESE M., FERRARACCIO, Franca, MARFELLA, Raffaele   +9 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Rapid neutral lipid accumulation of the alkali-resistant oleaginous Monoraphidium dybowskii LB50 by NaCl induction

, 2014
NaCl is an effective inducer of lipid accumulation in freshwater microalgae, but little is known on whether the enhanced lipid components are desired. To address this issue, Monoraphidium dybowskii LB50 from a freshwater habitat was selected, cultivated,
Yang, Haijian, Xia, Ling, He, Qiaoning, Rong, Junfeng, Hu, Chunxiang   +4 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Role of transcription factors in storage lipid accumulation in plants

, 2012
With few exceptions, seeds oil accumulates as triacylglycerols; three fatty acid molecules esterified to a glycerol backbone. The synthesis of normal fatty acids and unusual fatty acids, their assembly into triacylglycerols and subsequent packaging to ...
Fobert, Pierre R.
core   +1 more source

Activating PIK3CA mutation promotes overgrowth of adipose tissue via inhibiting lipophagy in macrodactyly

Cell Death and Disease
Excessive proliferation and lipid accumulation of adipose tissue are the main pathological alterations in macrodactyly. Our previous studies found that macrodactyly exhibits abnormal lipid metabolism and inhibited autophagy, but the underlying mechanisms
Yating Yin, Xiao Zhang, Shihui Lin, Zhibo Wang, Baoxing Tian, Xinyi Dai, Aiping Yu, Huixiao Li, Hailei Mao, Bin Wang   +9 more
doaj   +1 more source

Association between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes

, 2019
Jingyang Wu,1 Yifan Zhong,1 Song Yue,1 Peng Guan,2 Guisen Zhang,3 Lei Liu,1 Lei Chen11Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2Department of Epidemiology,
Yue S, Zhang G, Wu J, Liu L, Chen L, Zhong Y, Guan P   +6 more
core