Results 81 to 90 of about 557,479 (308)

Nanoreporter Identifies Lysosomal Storage Disease Lipid Accumulation Intracranially

, 2023
Dysregulated lipid metabolism contributes to neurodegenerative pathologies and neurological decline in lysosomal storage disorders as well as more common neurodegenerative diseases. Niemann–Pick type A (NPA) is a fatal neurodegenerative lysosomal storage
Lauren E. Komer (17296221), Emma Grabarnik (17296224), Dana Goerzen (17296212), Daniel A. Heller (1341873), Merav Antman-Passig (2546317), Adriana Haimovitz-Friedman (218062), Rooshi Parikh (17296215), Savannah Chatman (17296218), Chen Chen (6544), Mickael Mathieu (17296227), Zvi Yaari (4808325)   +10 more
core   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Lipid accumulation and dendritic cell dysfunction in cancer [PDF]

Nature Medicine, 2010
Dendritic cells (DCs), a type of professional antigen-presenting cells, are responsible for initiation and maintenance of immune responses. Here we report that a substantial proportion of DCs in tumor-bearing mice and people with cancer have high amounts of triglycerides as compared with DCs from tumor-free mice and healthy individuals. In our studies,
Herber, DL, Cao, W, Nefedova, Y, Novitskiy, SV, Nagaraj, S, Tyurin, VA, Corzo, A, Cho, H-I, Celis, E, Lennox, B, Knight, SC, Padhya, T, McCaffrey, TV, McCaffrey, JC, Antonia, S, Fishman, M, Ferris, RL, Kagan, VE, Gabrilovich, DI   +18 more
openaire   +3 more sources

Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome.

, 2009
We evaluated the role of sterol-regulatory element binding protein (SREBP)-1c/peroxisome proliferator activated receptor- * (PPAR * ) pathway on heart lipotoxicity in patients with metabolic syndrome (MS) and aortic stenosis (AS).
SINISCALCHI N., CACCIAPUOTI, Federico, DI FILIPPO, Clara, BARBIERI, Michelangela, ROSSI, Francesco, PAOLISSO, Giuseppe, D'AMICO, Michele, PORTOGHESE M., FERRARACCIO, Franca, MARFELLA, Raffaele   +9 more
core   +1 more source

ABHD5—A Regulator of Lipid Metabolism Essential for Diverse Cellular Functions

, 2022
The α/β-Hydrolase domain-containing protein 5 (ABHD5; also known as comparative gene identification-58, or CGI-58) is the causative gene of the Chanarin-Dorfman syndrome (CDS), a disorder mainly characterized by systemic triacylglycerol ...
Margarita Schratter, Achim Lass, Franz P. W. Radner, Schratter, Margarita, Lass, Achim, Radner, Franz P. W.   +5 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Choline supplementation prevents diet induced gut mucosa lipid accumulation in post-smolt Atlantic salmon (Salmo salar L.)

BMC Veterinary Research, 2020
Background Various intestinal morphological alterations have been reported in cultured fish fed diets with high contents of plant ingredients. Since 2000, salmon farmers have reported symptoms indicating an intestinal problem, which we suggest calling ...
Anne Kristine G. Hansen, Trond M. Kortner, Aleksei Krasnov, Ingemar Björkhem, Michael Penn, Åshild Krogdahl   +5 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The isocitrate dehydrogenase gene of oleaginous yeast Lipomyces starkeyi is linked to lipid accumulation

, 2009
The oleaginous yeast Lipomyces starkeyi can accumulate intracellular lipids to over 60% of its cell dry mass under a nitrogen-limited condition. We showed that extracellular and intracellular citrate concentrations of L.
Tang, Wei, 赵宗保, Zhao, Zongbao Kent, Wang, Qian, Tan, Haidong, Zhang, Sufang   +5 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source