Results 81 to 90 of about 2,038,928 (302)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Human resistin promotes macrophage lipid accumulation [PDF]

Diabetologia, 2006
The gene encoding resistin/FIZZ3 (found in inflammatory zone 3), which is denoted by the gene symbol RETN in humans and Retn in mice, belongs to a new gene family of small cysteine-rich secretory proteins, called ‘resistin-like molecules’, originally discovered in a search for adipocytederived molecules linking obesity and insulin-resistant diabetes [1]
Rae, C., Graham, Annette
openaire   +2 more sources

Regulation of the leading edge motility by PI (4,5)P2-dependent lipid microdomains [PDF]

, 2005
The lipid second messenger PI(4,5)P2 modulates actin dynamics, and its local accumulation at plasmalemmal microdomains (rafts) might mediate regulation of protrusive motility.
Golub, Tamara
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Interactive effects of nitrogen concentrations and light intensity on growth and lipid accumulation of Chlamydomonas reinhardtii

上海师范大学学报. 自然科学版, 2018
In order to explore the optimum condition of the growth and lipid accumulation of C. reinhardtii,our study investigated the lipid accumulation of C. reinhardtii across the gradients of nitrogen concentration and light intensity.The results showed that ...
CHEN Yujia, TU Xiaomeng, WANG Yongqiang, WANG Quanxi, XU Lili   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

SMA-3/Smad regulates lipid accumulation through adulthood.

, 2021
sma-3 animals exhibit reduced lipid accumulation during adulthood via ORO staining. This reduction is independent of reproduction, as treatment with FUDR prevents the development of eggs.
Katerina K. Yamamoto (11547614), James F. Clark (5250206), Peter Kayastha (8727767), Emma J. Ciccarelli (11547608), Uday Madaan (5250209), Muhammad S. Hasan (1821565), Cathy Savage-Dunn (4423588), Gehan Ranepura (11547611), Alicia Meléndez (525432)   +8 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Neutrophils Promote Metabolic Dysfunction‐Associated Steatotic Liver Disease Through Extracellular Vesicle‐mediated Lipid Transfer

Journal of Extracellular Vesicles
Metabolic dysfunction‐associated steatotic liver disease (MASLD) and metabolic dysfunction‐associated steatohepatitis are leading causes of chronic liver disease, yet the contribution of neutrophils to early hepatocellular lipid accumulation remains ...
Sanjeeb Shrestha, Soo‐Jung Jung, Seong‐Min Lim, Yu‐Bin Lee, Hyeung‐Wook Shin, Hoyul Lee, Hee‐Kyung Jin, Jae‐Sung Bae, Jae‐Han Jeon, Lai Guan Ng, Chang‐Won Hong   +10 more
doaj   +1 more source