Results 71 to 80 of about 1,939,990 (302)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Elevated levels of erythrocyte-conjugated dienes indicate increased lipid peroxidation in schistosomiasis mansoni patients [PDF]

, 2004
Schistosoma mansoni causes liver disease by inducing granulomatous inflammation. This favors formation of reactive oxygen species, including superoxide ions, hydrogen peroxide and hydroxyl radicals all of which may induce lipid peroxidation.
Owen, JS, Brandt, CT, Facundo, HT, Facundo, H.T.F., V.L.M. Lima, Lima, V.L.M., Lima, VL, J.S. Owen, Brandt, C.T., C.T. Brandt, H.T.F. Facundo, Owen, J.S.   +11 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Rosmarinic acid regulates lipid accumulation through lipid metabolism and anti-inflammatory

Food Science and Human Wellness
Obesity caused by poor eating habits has become a global public health issue and harms human health. Rosmarinic acid (RA) is a natural active substance with many biological functions like antioxidant.
Chunxiu Lin, Zhuobin Li, Yun Chen, Jingrui Luo, Guo Liu, Chi-Tang Ho, Yong Cao, Yunjiao Chen   +7 more
doaj   +1 more source

Regulation of the leading edge motility by PI (4,5)P2-dependent lipid microdomains [PDF]

, 2005
The lipid second messenger PI(4,5)P2 modulates actin dynamics, and its local accumulation at plasmalemmal microdomains (rafts) might mediate regulation of protrusive motility.
Golub, Tamara
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

AMPK affects the development of early-stage NAFLD by activating autophagy and fatty acid oxidation

Scientific Reports
Non-alcoholic fatty liver disease (NAFLD) ranks among the most common liver disorders, but the mechanisms underlying its early development are still not well understood.
Mei-yu Jin, Hao Yu, Qiong Deng, Zhu Wang, Hui Liang   +4 more
doaj   +1 more source

Fatty acid composition of chylomicron remnant-like particles influences their uptake and induction of lipid accumulation in macrophages

, 2006
The influence of the fatty acid composition of chylomicron remnant-like particles (CRLPs) on their uptake and induction of lipid accumulation in macrophages was studied.
De Pascale, C., Avella, M A, De Pascale, C, Wheeler-Jones, C P D, Wheeler-Jones, Caroline, Botham, K. M., Perona, J.S., Perona, Javier S., Wheeler-Jones, C.P.D., Ruiz-Gutiérrez, Valentina, Botham, K M, CSIC, Perona, J S, Ruiz-Gutierrez, V, Avella, M., Botham, K.M., Ruiz-Gutierrez, V., Avella, Michael, Pascale, Clara de   +18 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Interactive effects of nitrogen concentrations and light intensity on growth and lipid accumulation of Chlamydomonas reinhardtii

上海师范大学学报. 自然科学版, 2018
In order to explore the optimum condition of the growth and lipid accumulation of C. reinhardtii,our study investigated the lipid accumulation of C. reinhardtii across the gradients of nitrogen concentration and light intensity.The results showed that ...
CHEN Yujia, TU Xiaomeng, WANG Yongqiang, WANG Quanxi, XU Lili   +4 more
doaj   +1 more source