Results 51 to 60 of about 3,316,815 (349)

Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases

Cell & Bioscience, 2022
The importance of neuroglia in maintaining normal brain function under physiological and pathological conditions has been supported by growing evidence in recent years.
Danying Yang, Xifeng Wang, Lieliang Zhang, Yang Fang, Qingcui Zheng, Xing Liu, Wen Yu, Shoulin Chen, Jun Ying, Fuzhou Hua   +9 more
doaj   +1 more source

Antioxidant activities of plant extracts and essential oil-cyclodextrin complexes and their effect on lipid accumulation in porcine adipocytes in vitro

Veterinary Integrative Sciences, 2021
Fat deposition is important for pig production because excessive fat decreases the economic value of meat production. Plant extracts have been used as feed additive in pig diets to improve oxidative stability of meat. However, only a few studies
Rakkiat Norkeaw, Chaiwat Arjin, Apinya Sartsook, Niraporn Chaiwang, Supamit Mekchay, Sarana Rose Sommano, Warintorn Ruksiriwanich, Korawan Sringarm   +7 more
doaj   +1 more source

Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds [PDF]

, 2012
Reducing lipid accumulation in insulin target tissues is critical for the treatment of type 2 diabetes. This study aimed to develop a biochemical assay in cells for high throughput (HTP) screening of anti-diabetic drugs by reducing lipid accumulation via
Chan, S, Molero - Navajas, J, Xu, J, Xue, C, Ye, J, Zeng, X, Zhou, X   +6 more
core   +1 more source

Nonalcoholic Lipid Accumulation and Hepatocyte Malignant Transformation [PDF]

Journal of Clinical and Translational Hepatology, 2016
Worldwide incidence of hepatocellular carcinoma (HCC) is steadily increasing, highlighting its status as a public health concern, particularly due to its significant association with other comorbidities, such as diabetes. However, nonalcoholic fatty liver disease (NAFLD) has emerged as a primary risk factor, with its own prevalence increasing in recent
Gu, Juanjuan, Yao, Min, Yao, Dengbing, Wang, Li, Yang, Xuli, Yao, Dengfu   +5 more
openaire   +2 more sources

Development of a novel tocopheryl ester for suppression of lipid accumulation without cytotoxicity by optimization of dicarboxylic ester moiety

Biochemistry and Biophysics Reports, 2022
Tocopheryl succinate (Tsuc) is a succinic acid ester of the well-known antioxidant α-tocopherol (T). Tsuc exhibits various biological activities, including tumor growth suppression via activation of cell signaling and prevention of lipid accumulation in ...
Misaki Yamasaki, Yuika Seto, Mizune Ozono, Michiyasu Nakao, Akira Shigenaga, Akira Otaka, Shigeki Sano, Kentaro Kogure   +7 more
doaj   +1 more source

The pleiotropic transcriptional regulator NlpR contributes to the modulation of nitrogen metabolism, lipogenesis and triacylglycerol accumulation in oleaginous rhodococci [PDF]

, 2017
The regulatory mechanisms involved in lipogenesis and triacylglycerol (TAG) accumulation are largely unknown in oleaginous rhodococci. In this study a regulatory protein (here called NlpR: Nitrogen lipid Regulator), which contributes to the modulation of
Alvarez, Hector Manuel, Gago, Gabriela Marisa, Gramajo, Hugo Cesar, Hernández, Martín Alejandro, Lara, María Julia   +4 more
core   +1 more source

ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis

Journal of Translational Medicine
Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose global prevalence is rapidly increasing. Acetyl CoA carboxylases 1 (ACACA) is the key enzyme that controls the rate of fatty acid synthesis.
Jian Dong, Muzi Li, Runsheng Peng, Yuchuan Zhang, Zilin Qiao, Na Sun   +5 more
semanticscholar   +1 more source

Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy[S]

Journal of Lipid Research, 2017
Defective autophagy has been linked to lipotoxicity in several cellular models. We aimed to investigate autophagy in lipid-stimulated hepatoma (Huh7) cells and tested whether 4-phenyl butyric acid (4-PBA), a chemical chaperone, has a beneficial role in ...
Ashraf U. Nissar, Love Sharma, Malik A. Mudasir, Lone A. Nazir, Sheikh A. Umar, Parduman R. Sharma, Ram A. Vishwakarma, Sheikh A. Tasduq   +7 more
doaj   +1 more source

Exploiting Bioprocessing Fluctuations to Elicit the Mechanistics of De Novo Lipogenesis in Yarrowia lipolytica. [PDF]

PLoS ONE, 2017
Despite substantial achievements in elucidating the metabolic pathways of lipogenesis, a mechanistic representation of lipid accumulation and degradation has not been fully attained to-date.
Andreas E Vasdekis, Andrew M Silverman, Gregory Stephanopoulos   +2 more
doaj   +1 more source

TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. [PDF]

, 2014
In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy.
Seki, Ekihiro
core   +2 more sources