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Lipid Droplet Accumulation Promotes RPE Dysfunction
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Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
Nature Reviews Nephrology, 2023Chronic kidney disease (CKD) is a global health problem with rising incidence and prevalence. Among several pathogenetic mechanisms responsible for disease progression, lipid accumulation in the kidney parenchyma might drive inflammation and fibrosis, as has been described in fatty liver diseases.
A. Mitrofanova, S. Merscher, A. Fornoni
semanticscholar +5 more sources
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK.
Cell MetabolismThe accumulation of lipid droplets (LDs) in aging and Alzheimer's disease brains is considered a pathological phenomenon with unresolved cellular and molecular mechanisms. Utilizing stimulated Raman scattering (SRS) microscopy, we observed significant in
Yajuan Li +11 more
semanticscholar +3 more sources
Neuron, 2023
Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease (LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S mouse model of tauopathy, ApoE4 increases tau pathology and neurodegeneration when
Alexandra Litvinchuk +18 more
semanticscholar +1 more source
Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease (LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S mouse model of tauopathy, ApoE4 increases tau pathology and neurodegeneration when
Alexandra Litvinchuk +18 more
semanticscholar +1 more source
F.F.A., INTESTINAL BYPASS, AND ARTERIAL LIPID ACCUMULATION
The Lancet, 1978D.J.A. Jenkins, JohnG. Kral
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Metabolism: Clinical and Experimental, 2021
BACKGROUND Nucleotide leukin-rich polypeptide 3 (NLRP3) inflammasome is documented as a potent target for treating metabolic diseases and inflammatory disorders. Our recent work demonstrated that inhibition of NLRP3 inflammasome activation inhibits renal
Ming Wu +8 more
semanticscholar +1 more source
BACKGROUND Nucleotide leukin-rich polypeptide 3 (NLRP3) inflammasome is documented as a potent target for treating metabolic diseases and inflammatory disorders. Our recent work demonstrated that inhibition of NLRP3 inflammasome activation inhibits renal
Ming Wu +8 more
semanticscholar +1 more source
Science of the Total Environment, 2021
Energy is a major driving force for the economic development. Due to the scarcity of fossil fuels and negative impact on the environment, it is important to develop renewable and sustainable energy sources for humankind.
Xiangmeng Ma +3 more
semanticscholar +1 more source
Energy is a major driving force for the economic development. Due to the scarcity of fossil fuels and negative impact on the environment, it is important to develop renewable and sustainable energy sources for humankind.
Xiangmeng Ma +3 more
semanticscholar +1 more source
Controlling lipid accumulation in cereal grains
Plant Science, 2012Plant oils have so far been mostly directed toward food and feed production. Nowadays however, these oils are more and more used as competitive alternatives to mineral hydrocarbon-based products. This increasing demand for vegetable oils has led to a renewed interest in elucidating the metabolism of storage lipids and its regulation in various plant ...
Barthole, Guillaume +3 more
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Lipid Accumulation in Dysferlin-Deficient Muscles
The American Journal of Pathology, 2014Dysferlin is a membrane associated protein involved in vesicle trafficking and fusion. Defects in dysferlin result in limb-girdle muscular dystrophy type 2B and Miyoshi myopathy in humans and myopathy in A/J(dys-/-) and BLAJ mice, but the pathomechanism of the myopathy is not understood.
Grounds, M. +6 more
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