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Lipid Droplet Accumulation Promotes RPE Dysfunction
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Controlling lipid accumulation in cereal grains
Plant Science, 2012Plant oils have so far been mostly directed toward food and feed production. Nowadays however, these oils are more and more used as competitive alternatives to mineral hydrocarbon-based products. This increasing demand for vegetable oils has led to a renewed interest in elucidating the metabolism of storage lipids and its regulation in various plant ...
Barthole, Guillaume +3 more
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Lipid Accumulation in Dysferlin-Deficient Muscles
The American Journal of Pathology, 2014Dysferlin is a membrane associated protein involved in vesicle trafficking and fusion. Defects in dysferlin result in limb-girdle muscular dystrophy type 2B and Miyoshi myopathy in humans and myopathy in A/J(dys-/-) and BLAJ mice, but the pathomechanism of the myopathy is not understood.
Grounds, M. +6 more
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Neutral Lipid Accumulation in Macrophages During Lipid-Induced Macrophage Growth
Journal of Leukocyte Biology, 1989Abstract We previously reported that lipids such as cholesterol esters, triglycerides, and some phospholipids that are components of cell membranes or serum lipoproteins induced the growth of mouse peritoneal macrophages in vitro. Here, we report that macrophage growth was directly induced by lipids without any soluble factors and that ...
S, Yui, M, Yamazaki
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Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
Nature Reviews Nephrology, 2023Chronic kidney disease (CKD) is a global health problem with rising incidence and prevalence. Among several pathogenetic mechanisms responsible for disease progression, lipid accumulation in the kidney parenchyma might drive inflammation and fibrosis, as has been described in fatty liver diseases.
Alla Mitrofanova +2 more
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Enhanced extracellular lipid accumulation in acidic environments
Current Opinion in Lipidology, 2006Binding of apolipoprotein B-100-containing lipoproteins (VLDL, IDL, and LDL) to proteoglycans and modifications of the lipoproteins, whether bound or unbound, are key processes in atherogenesis. The complex interplay between binding and modification has been studied at neutral pH conditions.
Katariina, Oörni, Petri T, Kovanen
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Lipids easy to accumulate in the liver and lipids hard to accumulate in it
Nutrition Research, 1997Abstract Accumulation of lipids in the liver, fatty acid composition and molecular species of serum and hepatic triglycerides were investigated after rats were raised for 4 weeks with diets containing beef powder and 12% level of various lipids. Some diagnostic parameters in the serum and acetyl-CoA carboxylase and peroxisomal β-oxidation activities ...
Satoshi Kawahara +4 more
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Curcuma wenyujin rhizomes extract ameliorates lipid accumulation
FitoterapiaCurcuma wenyujin (C. wenyujin) is a medicinal plant that is traditionally used to treat blood stagnation, liver fibrosis, pain, and jaundice. In this study, we examined the effect of C. wenyujin rhizome extract on hepatic lipid accumulation both in vivo and in vitro. We found that the petroleum ether fraction of C.
Hong, Wang +5 more
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ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts
American Journal of Physiology-Endocrinology and Metabolism, 2002Adipose differentiation-related protein (ADRP) is a lipid droplet-associated protein that is expressed early during adipose differentiation. The present study was undertaken to reveal the role of ADRP in adipose differentiation. In murine fibroblasts infected with green fluorescent protein (GFP)-ADRP fusion protein expression adenovirus vector ...
Minako, Imamura +6 more
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