Results 131 to 140 of about 118,445 (283)
, 2017 The global obesity epidemic and its associated co-morbidities, including type 2 diabetes, cardiovascular disease and certain types of cancers, have drawn attention to the pivotal role of adipocytes in health and disease.
Robert J. van Eijkeren +9 more
core +1 more source
Advanced Materials, EarlyView.Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou +5 more
wiley +1 more source
Lipid antigens in adipose tissue : A CD1d centered view on adipocyte - iNKT cell communication
, 2022 Fat tissue is more than just fat cells that store lipids. It is a highly complex tissue with a large variety of different cells that have different functions both locally and throughout the whole body.
Eijkeren, Robert Johannes van
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Super‐Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles
Advanced Materials, EarlyView.This study presents a super‐resolution ultrasound platform for tracking cells in vivo. Biocompatible polymeric nanobubbles are used as highly echogenic intracellular labels. Following the injection of cells and microbubbles, ultrasound localization microscopy (ULM) can dynamically match the microvascular architecture and individual cell trajectories ...
Junlin Chen +19 more
wiley +1 more source
Advanced Materials Technologies, EarlyView.ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali +4 more
wiley +1 more source
Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis
, 2010 Studies on Mycobacterium tuberculosis (MTB) antigens are important to improve immunodiagnostics and vaccine efficacy. A novel genome based strategy for antigen discovery is to relate what is highly expressed by bacilli in vivo or in vitro, to what is ...
Gideon, Hannah Priyadarshini
core
, 2014 Obesity-induced adipose tissue (AT) dysfunction results in a chronic low-grade inflammation that predisposes to the development of insulin resistance and type 2 diabetes.
Rakhshandehroo, Maryam +8 more
core +1 more source
Advanced Science, EarlyView.Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater +13 more
wiley +1 more source
Lipids in immunometabolism: From lipid handling to lipid antigen presentation and back
Within this thesis we utilized and developed several model systems allowing us to strategically address the different levels of complex interactions and mechanisms. In chapter 2 we use a mixture of FFA’s mimicking the lipid-rich microenvironment of obesity in vitro, co-culturing these now insulin resistant (IR) adipocytes with iNKT cells demonstrated ...
Morris, Imogen +4 more
openaire +3 more sources
, 2001 Dendritic cells (DCs) are the most potent antigen presenting cells for inducing T-cell immune responses. The ability to grow human DCs from monocyte precursors provides an abundant source of these cells, which can be modified in vitro to present antigens.
Smith, SG +7 more
core +1 more source