CD1-restricted T cells: are unconventional allies the key to future TB vaccines? [PDF]
Frontiers in ImmunologyCD1-restricted T cells constitute an unconventional arm of immunity that recognises lipid antigens, a feature particularly pertinent to Mycobacterium tuberculosis (Mtb), a pathogen with a lipid-rich cell wall.
Matthew Milton +2 more
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Lipid Antigens: Revealing the Hidden Players in Adaptive Immune Responses [PDF]
BiomoleculesTraditionally, research on the adaptive immune system has focused on protein antigens, but emerging evidence has underscored the essential role of lipid antigens in immune modulation.
Tamana Eskandari +5 more
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Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy [PDF]
MedComm (2020)Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
He W, McMichael A.
europepmc +2 more sources
Unconventional T cells in anti-cancer immunity [PDF]
Frontiers in ImmunologyUnlike conventional T cells that detect peptide antigens loaded to major histocompatibility complex (MHC) molecules, unconventional T cells respond to non-peptidic metabolite antigens presented by MHC class I-like proteins, such as CD1 and MHC-related ...
Ariel Laub +4 more
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Insights into the CD1 lipidome [PDF]
Frontiers in ImmunologyCD1 isoforms are MHC class I-like molecules that present lipid-antigens to T cells and have been associated with a variety of immune responses. The lipid repertoire bound and presented by the four CD1 isoforms may be influenced by factors such as the ...
Rita Szoke-Kovacs +4 more
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Sideways lipid presentation by the antigen-presenting molecule CD1c [PDF]
Nature CommunicationsFor the MHC, MR1 and CD1 systems, antigen recognition involves contact of the membrane distal surfaces of both the αβ T cell receptor (TCR) and the antigen-presenting molecule.
Thinh-Phat Cao +17 more
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Features of the CD1 gene family in rodents and the uniqueness of the immune system of naked mole-rat [PDF]
Biology DirectCluster of Differentiation 1 (CD1) proteins are widely expressed throughout jawed vertebrates and present lipid antigens to specific CD1-restricted T lymphocytes.
Konstantin V. Gunbin +3 more
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Experimental and Molecular Medicine, 2023 The cluster of differentiation 1 (CD1) molecule differs from major histocompatibility complex class I and II because it presents glycolipid/lipid antigens. Moreover, the CD1-restricted T cells that recognize these self and foreign antigens participate in
Seohyun Kim, Sumin Cho, Ji Hyung Kim
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ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]
, 2020 CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun +12 more
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Expression patterns of bovine CD1 in vivo and assessment of the specificities of the anti-bovine CD1 antibodies. [PDF]
PLoS ONE, 2015 Research addressing the in vivo effects of T cell activation by lipids, glycolipids, and lipopeptides is hampered by the absence of a suitable animal model.
Thi Kim Anh Nguyen +6 more
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