Results 1 to 10 of about 11,539 (211)
CD1-restricted T cells: are unconventional allies the key to future TB vaccines? [PDF]
Frontiers in ImmunologyCD1-restricted T cells constitute an unconventional arm of immunity that recognises lipid antigens, a feature particularly pertinent to Mycobacterium tuberculosis (Mtb), a pathogen with a lipid-rich cell wall.
Matthew Milton +2 more
doaj +3 more sources
Role of Group 1 CD1-Restricted T Cells in Infectious Disease
Frontiers in Immunology, 2015 The evolutionarily conserved CD1 family of antigen-presenting molecules presents lipid antigens rather than peptide antigens to T cells. CD1 molecules, unlike classical MHC molecules, display limited polymorphism, making CD1-restricted lipid antigens ...
Sarah Siddiqui +2 more
exaly +4 more sources
CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms [PDF]
Cell, 2023 The CD1 system binds lipid antigens for display to T cells. Here, we solved lipidomes for the four human CD1 antigen-presenting molecules, providing a map of self-lipid display.
Shouxiong Huang +2 more
exaly +3 more sources
Expression patterns of bovine CD1 in vivo and assessment of the specificities of the anti-bovine CD1 antibodies. [PDF]
PLoS ONE, 2015 Research addressing the in vivo effects of T cell activation by lipids, glycolipids, and lipopeptides is hampered by the absence of a suitable animal model.
Thi Kim Anh Nguyen +6 more
doaj +2 more sources
Clinical and Developmental Immunology, 2011 Group I CD1 (CD1a, CD1b, and CD1c) glycoproteins expressed on immature and mature dendritic cells present nonpeptide antigens (i.e., lipid or glycolipid molecules mainly of microbial origin) to T cells.
Angelo Aquino +6 more
doaj +2 more sources
Lipid Antigens: Revealing the Hidden Players in Adaptive Immune Responses [PDF]
BiomoleculesTraditionally, research on the adaptive immune system has focused on protein antigens, but emerging evidence has underscored the essential role of lipid antigens in immune modulation.
Tamana Eskandari +5 more
doaj +2 more sources
The T cell response to lipid antigens of Mycobacterium tuberculosis
Frontiers in Immunology, 2014 T cells recognize lipid antigens presented by dedicated antigen presenting molecules that belong to the CD1 family. This review discusses the structural properties of CD1 molecules, the nature of mycobacterial lipid antigens, and the phenotypic and ...
Gennaro eDe Libero +2 more
doaj +3 more sources
CD1-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity
Journal of Immunology Research, 2016 Lipid-specific T cells comprise a group of T cells that recognize lipids bound to the MHC class I-like CD1 molecules. There are four isoforms of CD1 that are expressed at the surface of antigen presenting cells and therefore capable of presenting lipid ...
Catia S. Pereira, M. Fatima Macedo
doaj +2 more sources
Unconventional T cells in anti-cancer immunity [PDF]
Frontiers in ImmunologyUnlike conventional T cells that detect peptide antigens loaded to major histocompatibility complex (MHC) molecules, unconventional T cells respond to non-peptidic metabolite antigens presented by MHC class I-like proteins, such as CD1 and MHC-related ...
Ariel Laub +4 more
doaj +2 more sources
Adoptive T cell therapy targeting CD1 and MR1
Frontiers in Immunology, 2015 Adoptive T cell immunotherapy has demonstrated clinically relevant efficacy in treating malignant and infectious diseases. However, much of these therapies have been focused on enhancing, or generating de novo, effector functions of conventional T cells ...
Tingxi eGuo +4 more
doaj +2 more sources