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Novel lipid antigens for NKT cells in cancer [PDF]
Frontiers in Immunology, 2023 Cancer immunotherapy aims to unleash the power of the immune system against tumors without the side effects of traditional chemotherapy. Immunotherapeutic methods vary widely, but all follow the same basic principle: overcome the barriers utilized by ...
Michael S. Lee +3 more
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Lipid antigens in immunity. [PDF]
Biol Chem, 2014 Abstract Lipids are not only a central part of human metabolism but also play diverse and critical roles in the immune system. As such, they can act as ligands of lipid-activated nuclear receptors, control inflammatory signaling through bioactive lipids such as prostaglandins, leukotrienes, lipoxins, resolvins, and protectins, and ...
Dowds CM +3 more
europepmc +4 more sources
Lipid Antigens: Revealing the Hidden Players in Adaptive Immune Responses [PDF]
BiomoleculesTraditionally, research on the adaptive immune system has focused on protein antigens, but emerging evidence has underscored the essential role of lipid antigens in immune modulation.
Tamana Eskandari +5 more
doaj +2 more sources
Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface. [PDF]
Proc Natl Acad Sci U S A, 2017 Glycolipid antigens recognized by αβ T-cell receptors (TCRs) drive the activation of invariant natural killer T (iNKT) cells, a specialized subset of innate T lymphocytes.
Brennan PJ +10 more
europepmc +4 more sources
How T cells grasp mycobacterial lipid antigens. [PDF]
Proc Natl Acad Sci U S A, 2017 Solving the mechanism by which MHC I and II proteins capture protein fragments represented a triumph for T cell biologists. This discovery highlighted the peptidic nature of antigens for T cells. Investigation of MHC-peptide–T cell receptor (TCR) interactions provides the basis for epitope mapping, which is the process of identifying the particular ...
Moody DB.
europepmc +4 more sources
The T cell response to lipid antigens of Mycobacterium tuberculosis [PDF]
Frontiers in Immunology, 2014 T cells recognize lipid antigens presented by dedicated antigen presenting molecules that belong to the CD1 family. This review discusses the structural properties of CD1 molecules, the nature of mycobacterial lipid antigens, and the phenotypic and ...
Gennaro eDe Libero +2 more
doaj +2 more sources
Buffy Coat Processing Impacts on Monocytes’ Capacity to Present Lipid Antigens [PDF]
Biomedicines, 2023 Buffy Coats, generated from a blood donor’s whole blood bag unit, are commonly used in biomedical research as a source of leukocytes due to the high number of cells that can be recovered from each Buffy Coat.
Inês Mondragão-Rodrigues +1 more
doaj +2 more sources
New synthetic lipid antigens for rapid serological diagnosis of tuberculosis. [PDF]
PLoS ONE, 2017 BackgroundDuring pulmonary tuberculosis (PTB) antibodies are generated to trehalose esters of mycolic acids which are cell wall lipids of Mycobacterium tuberculosis (Mtb). Attempts have been made to use these complex natural mixtures in serological tests
Alison Jones +7 more
doaj +2 more sources
Preparing Adjuvanted Nanoliposomes for Applications Toward Recombinant Influenza Vaccine Development [PDF]
Bio-ProtocolNanoparticle vaccines can provide advantages over traditional vaccine methodologies, including adjuvant delivery to enhance the effectiveness of recombinant antigens.
Zachary Sia +5 more
doaj +2 more sources
Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens [PDF]
Nature Communications, 2016 The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus ...
Jérôme Le Nours +13 more
doaj +2 more sources