Novel lipid antigens for NKT cells in cancer. [PDF]
Front Immunol, 2023 Cancer immunotherapy aims to unleash the power of the immune system against tumors without the side effects of traditional chemotherapy. Immunotherapeutic methods vary widely, but all follow the same basic principle: overcome the barriers utilized by ...
Lee MS, Webb TJ.
europepmc +2 more sources
Lipid Antigens: Revealing the Hidden Players in Adaptive Immune Responses. [PDF]
BiomoleculesTraditionally, research on the adaptive immune system has focused on protein antigens, but emerging evidence has underscored the essential role of lipid antigens in immune modulation.
Eskandari T +5 more
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Buffy Coat Processing Impacts on Monocytes' Capacity to Present Lipid Antigens. [PDF]
Biomedicines, 2023 Buffy Coats, generated from a blood donor’s whole blood bag unit, are commonly used in biomedical research as a source of leukocytes due to the high number of cells that can be recovered from each Buffy Coat.
Mondragão-Rodrigues I, Macedo MF.
europepmc +2 more sources
The T-Cell Response to Lipid Antigens of Mycobacterium tuberculosis. [PDF]
Front Immunol, 2014 T cells recognize lipid antigens presented by dedicated antigen presenting molecules that belong to the CD1 family. This review discusses the structural properties of CD1 molecules, the nature of mycobacterial lipid antigens, and the phenotypic and ...
De Libero G, Mori L.
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New synthetic lipid antigens for rapid serological diagnosis of tuberculosis. [PDF]
PLoS One, 2017 BackgroundDuring pulmonary tuberculosis (PTB) antibodies are generated to trehalose esters of mycolic acids which are cell wall lipids of Mycobacterium tuberculosis (Mtb). Attempts have been made to use these complex natural mixtures in serological tests
Jones A +7 more
europepmc +2 more sources
In Vitro Selection of Antibodies Targeting <i>Yersinia pestis</i> Membrane Lipids Using Nanodisc-Based Antigen Presentation. [PDF]
PathogensProteins are the most common targets for antibody discovery and vaccine development, but their sequence variability can limit the breadth of resulting antigens.
Bolding MR +5 more
europepmc +2 more sources
A Longitudinal Study of <i>Mycobacterium avium</i> Subspecies <i>paratuberculosis</i> Infections in Cattle Using Lipid Antigens and Providing Evidence for Age-Associated Antibody Dynamics. [PDF]
Animals (Basel)The problem: Johne’s disease, caused by infection with Mycobacterium avium subspecies paratuberculosis (MAP), can be widespread in cattle herds. As a consequence of the slow progression of the infection and the delayed appearance of a humoral response ...
Hughes V +6 more
europepmc +2 more sources
Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens. [PDF]
Nat Commun, 2016 The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus ...
Le Nours J +13 more
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Structural determination of lipid antigens captured at the CD1d–T-cell receptor interface [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Daniel G Pellicci +2 more
exaly +2 more sources
NKT Cells Contribute to the Control of Microbial Infections
Frontiers in Cellular and Infection Microbiology, 2021 Innate (-like) T lymphocytes such as natural killer T (NKT) cells play a pivotal role in the recognition of microbial infections and their subsequent elimination.
Stefan Vogt +2 more
doaj +1 more source