Results 11 to 20 of about 122,182 (249)
Lipid antigens in immunity. [PDF]
Biol Chem, 2014 Abstract Lipids are not only a central part of human metabolism but also play diverse and critical roles in the immune system. As such, they can act as ligands of lipid-activated nuclear receptors, control inflammatory signaling through bioactive lipids such as prostaglandins, leukotrienes, lipoxins, resolvins, and protectins, and ...
Dowds CM +3 more
europepmc +4 more sources
The CD1 size problem: lipid antigens, ligands, and scaffolds [PDF]
Cellular and Molecular Life Sciences, 2014 Dalam Ly, David Branch Moody
exaly +2 more sources
Lipase Processing of Complex Lipid Antigens [PDF]
Cell Chemical Biology, 2016 Mycobacterium tuberculosis synthesizes a wide variety of complex lipids that can serve as antigens in immune recognition of the bacterium. In this issue of Cell Chemical Biology, Gilleron et al. (2016) identify key enzymes essential for lipid antigen processing, which is required for CD1b-restricted T cell activation.
Sander P., Becker K., Dal Molin M.
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Frontiers in Immunology, 2020 Methicillin-resistant Staphylococcus aureus (SA) bacteremia is responsible for over 10,000 deaths in the hospital setting each year. Both conventional CD4+ T cells and γδ T cells play protective roles in SA infection through secretion of IFN-γ and IL-17.
Samantha Genardi +9 more
doaj +1 more source
JCI Insight, 2023 Invariant natural killer T (iNKT) cells act at the interface between lipid metabolism and immunity because of their restriction to lipid antigens presented on CD1d by antigen-presenting cells (APCs).
Suzanne E. Engelen +24 more
doaj +1 more source
Lipid-Reactive T Cells in Immunological Disorders of the Lung
Frontiers in Immunology, 2018 Regulation of T cell-mediated immunity in the lungs is critical for prevention of immune-related lung disorders and for host protection from pathogens.
Seungwon Ryu +5 more
doaj +1 more source
Structural Dynamics of the Lipid Antigen-Binding Site of CD1d Protein
Biomolecules, 2020 CD1 molecules present lipid antigens to T-cells in early stages of immune responses. Whereas CD1‒lipid‒T-cell receptors interactions are reasonably understood, molecular details on initial trafficking and loading of lipids onto CD1 proteins are less ...
Bruno Cuevas-Zuviría +4 more
doaj +1 more source
Antigenic heterogeneity of lipid A of Haemophilus influenzae [PDF]
Infection and Immunity, 1985 The chemical structure and biologic function of the lipid A portion of lipopolysaccharide are not identical among gram-negative bacteria. This study indicates that antigenically heterogeneous lipid A exists among strains of Haemophilus influenzae. An immunoglobulin G3 murine monoclonal antibody, 3D2, produced against a nontypable H.
M A, Apicella +5 more
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Tumor Lipids of Pediatric Papillary Renal Cell Carcinoma Stimulate Unconventional T Cells
Frontiers in Immunology, 2020 Papillary renal cell carcinoma (PRCC) is a rare entity in children with no established therapy protocols for advanced diseases. Immunotherapy is emerging as an important therapeutic tool for childhood cancer.
Nadine Lehmann +22 more
doaj +1 more source
Presentation of Lipid Antigens by CD1 Glycoproteins [PDF]
Current Pharmaceutical Design, 2009 CD1 molecules are a family of non-polymorphic, class I antigen-presenting glycoproteins, which bind and present amphiphilic lipid antigens for recognition to T cells. Two groups of CD1 molecules are involved in presentation of self and foreign lipid antigens: group 1 (CD1a, CD1b and CD1c) and group 2 (CD1d). Crystal structures of CD1a, CD1b and CD1d in
André, Schiefner, Ian A, Wilson
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