Results 11 to 20 of about 199,961 (298)
Editing of CD1d-Bound Lipid Antigens by Endosomal Lipid Transfer Proteins [PDF]
Science, 2004 It is now established that CD1 molecules present lipid antigens to T cells, although it is not clear how the exchange of lipids between membrane compartments and the CD1 binding groove is assisted. We report that mice deficient in prosaposin, the precursor to a family of endosomal lipid transfer proteins (LTP), exhibit specific defects in CD1d-mediated
Dapeng, Zhou +12 more
openaire +4 more sources
NKT Cells Contribute to the Control of Microbial Infections
Frontiers in Cellular and Infection Microbiology, 2021 Innate (-like) T lymphocytes such as natural killer T (NKT) cells play a pivotal role in the recognition of microbial infections and their subsequent elimination.
Stefan Vogt +2 more
doaj +1 more source
Lipase Processing of Complex Lipid Antigens [PDF]
Cell Chemical Biology, 2016 Mycobacterium tuberculosis synthesizes a wide variety of complex lipids that can serve as antigens in immune recognition of the bacterium. In this issue of Cell Chemical Biology, Gilleron et al. (2016) identify key enzymes essential for lipid antigen processing, which is required for CD1b-restricted T cell activation.
Sander P., Becker K., Dal Molin M.
openaire +2 more sources
ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]
, 2020 CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun +12 more
core +2 more sources
Frontiers in Immunology, 2020 Methicillin-resistant Staphylococcus aureus (SA) bacteremia is responsible for over 10,000 deaths in the hospital setting each year. Both conventional CD4+ T cells and γδ T cells play protective roles in SA infection through secretion of IFN-γ and IL-17.
Samantha Genardi +9 more
doaj +1 more source
JCI Insight, 2023 Invariant natural killer T (iNKT) cells act at the interface between lipid metabolism and immunity because of their restriction to lipid antigens presented on CD1d by antigen-presenting cells (APCs).
Suzanne E. Engelen +24 more
doaj +1 more source
Lipid-Reactive T Cells in Immunological Disorders of the Lung
Frontiers in Immunology, 2018 Regulation of T cell-mediated immunity in the lungs is critical for prevention of immune-related lung disorders and for host protection from pathogens.
Seungwon Ryu +5 more
doaj +1 more source
Structural Dynamics of the Lipid Antigen-Binding Site of CD1d Protein
Biomolecules, 2020 CD1 molecules present lipid antigens to T-cells in early stages of immune responses. Whereas CD1‒lipid‒T-cell receptors interactions are reasonably understood, molecular details on initial trafficking and loading of lipids onto CD1 proteins are less ...
Bruno Cuevas-Zuviría +4 more
doaj +1 more source
The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition [PDF]
, 2016 M. tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding
Barry III, CE +5 more
core +1 more source
Tumor Lipids of Pediatric Papillary Renal Cell Carcinoma Stimulate Unconventional T Cells
Frontiers in Immunology, 2020 Papillary renal cell carcinoma (PRCC) is a rare entity in children with no established therapy protocols for advanced diseases. Immunotherapy is emerging as an important therapeutic tool for childhood cancer.
Nadine Lehmann +22 more
doaj +1 more source