Results 11 to 20 of about 118,445 (283)
Novel lipid antigens for NKT cells in cancer [PDF]
Frontiers in Immunology, 2023 Cancer immunotherapy aims to unleash the power of the immune system against tumors without the side effects of traditional chemotherapy. Immunotherapeutic methods vary widely, but all follow the same basic principle: overcome the barriers utilized by cancers to avoid immune destruction.
Michael S Lee +2 more
exaly +6 more sources
The T-Cell Response to Lipid Antigens of Mycobacterium tuberculosis [PDF]
Frontiers in Immunology, 2014 T cells recognize lipid antigens presented by dedicated antigen presenting molecules that belong to the CD1 family. This review discusses the structural properties of CD1 molecules, the nature of mycobacterial lipid antigens, and the phenotypic and ...
Gennaro De Libero +2 more
exaly +6 more sources
Lipid Antigens: Revealing the Hidden Players in Adaptive Immune Responses [PDF]
BiomoleculesTraditionally, research on the adaptive immune system has focused on protein antigens, but emerging evidence has underscored the essential role of lipid antigens in immune modulation.
Valentyn Oksenych +2 more
exaly +5 more sources
How T lymphocytes recognize lipid antigens
FEBS Letters, 2006 Recognition of lipid antigens by T lymphocytes is well established. Lipids are recognized by T cells when presented in association with CD1 antigen‐presenting molecules. Both microbial and self lipids stimulate specific T lymphocytes, thus participating in immune reactions during infections and autoimmune diseases.
Gennaro De Libero, Lucia Mori
exaly +5 more sources
Structural determination of lipid antigens captured at the CD1d–T-cell receptor interface [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Glycolipid antigens recognized by αβ T-cell receptors (TCRs) drive the activation of invariant natural killer T (iNKT) cells, a specialized subset of innate T lymphocytes.
Tan-Yun Cheng +2 more
exaly +4 more sources
Lipid antigens in immunity. [PDF]
Biol Chem, 2014 Abstract Lipids are not only a central part of human metabolism but also play diverse and critical roles in the immune system. As such, they can act as ligands of lipid-activated nuclear receptors, control inflammatory signaling through bioactive lipids such as prostaglandins, leukotrienes, lipoxins, resolvins, and protectins, and ...
Dowds CM +3 more
europepmc +4 more sources
Lipase Processing of Complex Lipid Antigens [PDF]
Cell Chemical Biology, 2016 Mycobacterium tuberculosis synthesizes a wide variety of complex lipids that can serve as antigens in immune recognition of the bacterium. In this issue of Cell Chemical Biology, Gilleron et al. (2016) identify key enzymes essential for lipid antigen processing, which is required for CD1b-restricted T cell activation.
Sander P., Becker K., Dal Molin M.
openaire +4 more sources
Acid Test: Lipid Antigens Get into the Groove [PDF]
Immunity, 2008 How do CD1 molecules load lipid antigens? In this issue of Immunity, Relloso et al. (2008) uncover how lysosomal pH targets amino acids in CD1b, causing it to open and attain a conformation more receptive to lipid antigens.
Kronenberg, Mitchell +1 more
openaire +3 more sources
Ether lipid vesicle-based antigens impart protection against experimental listeriosis
International Journal of Nanomedicine, 2012 Mairaj Ahmed Ansari,1 Swaleha Zubair,2 Saba Tufail,1 Ejaj Ahmad,1 Mohsin Raza Khan,1 Zainuddin Quadri,1 Mohammad Owais,11Interdisciplinary Biotechnology Unit, 2Women's College, Aligarh Muslim University, Aligarh, UP, IndiaBackground: Incidence of
Ansari MA +6 more
doaj +1 more source
Molecular Recognition of Lipid Antigens by T Cell Receptors [PDF]
The Journal of Experimental Medicine, 1999 The T cell antigen receptor (TCR) mediates recognition of peptide antigens bound in the groove of major histocompatibility complex (MHC) molecules. This dual recognition is mediated by the complementarity-determining residue (CDR) loops of the α and β chains of a single TCR which contact exposed residues of the peptide antigen and amino acids along the
Grant EP +7 more
openaire +6 more sources