Results 31 to 40 of about 122,182 (249)

Editing of CD1d-Bound Lipid Antigens by Endosomal Lipid Transfer Proteins [PDF]

Science, 2004
It is now established that CD1 molecules present lipid antigens to T cells, although it is not clear how the exchange of lipids between membrane compartments and the CD1 binding groove is assisted. We report that mice deficient in prosaposin, the precursor to a family of endosomal lipid transfer proteins (LTP), exhibit specific defects in CD1d-mediated
Dapeng, Zhou, Carlos, Cantu, Yuval, Sagiv, Nicolas, Schrantz, Ashok B, Kulkarni, Xiaoyang, Qi, Don J, Mahuran, Carlos R, Morales, Gregory A, Grabowski, Kamel, Benlagha, Paul, Savage, Albert, Bendelac, Luc, Teyton   +12 more
openaire   +2 more sources

Role of Group 1 CD1-restricted T Cells in Infectious Disease

Frontiers in Immunology, 2015
The evolutionarily conserved CD1 family of antigen-presenting molecules presents lipid antigens rather than peptide antigens to T cells. CD1 molecules, unlike classical MHC molecules, display limited polymorphism, making CD1-restricted lipid antigens ...
Sarah eSiddiqui, Lavanya eVisvabharathy, Chyung-Ru eWang   +2 more
doaj   +1 more source

CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system

Experimental and Molecular Medicine, 2023
The cluster of differentiation 1 (CD1) molecule differs from major histocompatibility complex class I and II because it presents glycolipid/lipid antigens. Moreover, the CD1-restricted T cells that recognize these self and foreign antigens participate in
Seohyun Kim, Sumin Cho, Ji Hyung Kim
doaj   +1 more source

Leptospira Lipid A Is a Potent Adjuvant That Induces Sterilizing Immunity against Leptospirosis

Vaccines, 2023
Leptospirosis is a globally significant zoonotic disease. The current inactivated vaccine offers protection against specific serovars but does not provide complete immunity.
Vivek P. Varma, Mohammad Kadivella, Sridhar Kavela, Syed M. Faisal   +3 more
doaj   +1 more source

Immunogenicity and antigenicity of synthetic Escherichia coli lipid A [PDF]

Infection and Immunity, 1986
The immunogenicity and antigenicity of synthetic Escherichia coli lipid A (compound 506) and its 1- and 4'-monophosphorylated derivatives (compounds 505 and 504, respectively) and nonphosphorylated derivative (compound 503) were compared with those of bis- and 4'-monophosphorylated natural free lipid A from E. coli.
L, Brade, E T, Rietschel, S, Kusumoto, T, Shiba, H, Brade   +4 more
openaire   +2 more sources

Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients

Frontiers in Immunology, 2019
The lysosome has a key role in the presentation of lipid antigens by CD1 molecules. While defects in lipid antigen presentation and in invariant Natural Killer T (iNKT) cell response were detected in several mouse models of lysosomal storage diseases ...
Catia S. Pereira, Catia S. Pereira, Begoña Pérez-Cabezas, Begoña Pérez-Cabezas, Helena Ribeiro, Helena Ribeiro, Helena Ribeiro, M. Luz Maia, M. Teresa Cardoso, Ana F. Dias, Olga Azevedo, M. Fatima Ferreira, Paula Garcia, Esmeralda Rodrigues, Paulo Castro-Chaves, Esmeralda Martins, Patricio Aguiar, Mercè Pineda, Yasmina Amraoui, Simona Fecarotta, Elisa Leão-Teles, Shenglou Deng, Paul B. Savage, M. Fatima Macedo, M. Fatima Macedo, M. Fatima Macedo   +25 more
doaj   +1 more source

Re-programming mouse liver-resident invariant natural killer T cells for suppressing hepatic and diabetogenic autoimmunity

Nature Communications, 2022
Invariant natural killer T (iNKT) cells are tissue-resident immune cells recognizing lipid antigens. Here the authors find that liver, but not lung nor spleen, iNKT cells alter their transcriptome upon systemic treatment of lipid nanoparticles for the ...
Channakeshava Sokke Umeshappa, Patricia Solé, Jun Yamanouchi, Saswat Mohapatra, Bas G. J. Surewaard, Josep Garnica, Santiswarup Singha, Debajyoti Mondal, Elena Cortés-Vicente, Charlotte D’Mello, Andrew Mason, Paul Kubes, Pau Serra, Yang Yang, Pere Santamaria   +14 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Pollen lipidomics: lipid profiling exposes a notable diversity in 22 allergenic pollen and potential biomarkers of the allergic immune response. [PDF]

PLoS ONE, 2013
BACKGROUND/AIM: Pollen grains are the male gametophytes that deliver sperm cells to female gametophytes during sexual reproduction of higher plants. Pollen is a major source of aeroallergens and environmental antigens.
Mohamed Elfatih H Bashir, Jan Hsi Lui, Ravishankar Palnivelu, Robert M Naclerio, Daphne Preuss   +4 more
doaj   +1 more source

Presenting lipid antigens

The Journal of Cell Biology, 2005
Immune cells inspect not just protein but also lipid antigens, thanks to presentation by the MHC relative CD1. Now, results from Peter van den Elzen, Michael Brenner (Harvard Medical School, Boston MA), and colleagues show that immune cells co-opt normal pathways of fat metabolism to deliver ...
openaire   +2 more sources