Structural Dynamics of the Lipid Antigen-Binding Site of CD1d Protein
Biomolecules, 2020 CD1 molecules present lipid antigens to T-cells in early stages of immune responses. Whereas CD1‒lipid‒T-cell receptors interactions are reasonably understood, molecular details on initial trafficking and loading of lipids onto CD1 proteins are less ...
Bruno Cuevas-Zuviría +4 more
doaj +1 more source
A novel self-lipid antigen targets human T cells against CD1c(+) leukemias [PDF]
, 2014 T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects.
Lepore, Marco +69 more
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Antigenic heterogeneity of lipid A of Haemophilus influenzae [PDF]
Infection and Immunity, 1985 The chemical structure and biologic function of the lipid A portion of lipopolysaccharide are not identical among gram-negative bacteria. This study indicates that antigenically heterogeneous lipid A exists among strains of Haemophilus influenzae. An immunoglobulin G3 murine monoclonal antibody, 3D2, produced against a nontypable H.
M A, Apicella +5 more
openaire +2 more sources
Tumor Lipids of Pediatric Papillary Renal Cell Carcinoma Stimulate Unconventional T Cells
Frontiers in Immunology, 2020 Papillary renal cell carcinoma (PRCC) is a rare entity in children with no established therapy protocols for advanced diseases. Immunotherapy is emerging as an important therapeutic tool for childhood cancer.
Nadine Lehmann +22 more
doaj +1 more source
Assessing the response of T cells to "Mycobacterium tuberculosis" lipids [PDF]
, 2008 Most vaccines used nowadays are created using inactivated or attenuated compounds from micro-organisms. Advances in basic immunology and molecular biology opened the gate for consequent improvement of vaccination strategies.
Collmann, Anthony
core +1 more source
Immunity to Intracellular Salmonella Depends on Surface-associated Antigens [PDF]
, 2012 Invasive Salmonella infection is an important health problem that is worsening because of rising antimicrobial resistance and changing Salmonella serovar spectrum.
Rizos Konstantin +50 more
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Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination. [PDF]
, 2007 Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis (TB), despite its variable protective efficacy. Relatively little is known about the immune response profiles following BCG vaccination in relation to protection against TB. Here we
Klein, Michèl R +12 more
core +2 more sources
Integration of a virus membrane protein into the lipid bilayer of target cells as a prerequisite for immune cytolysis [PDF]
, 1979 Structural requirements for membrane antigens on target cells to mediate immune cytolysis were studied in a model system with purified membrane proteins from Semliki Forest virus (SFV). These SFV spike proteins were isolated in the form of detergent- and
Schirrmacher, V. +7 more
core +1 more source
Vaccine approaches for antigen capture by liposomes
Expert Review of Vaccines, 2023 Introduction Liposomes have been used as carriers for vaccine adjuvants and antigens due to their inherent biocompatibility and versatility as delivery vehicles.
Shiqi Zhou, Yuan Luo, Jonathan Lovell
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Identification of protective antigens for vaccination against systemic salmonellosis [PDF]
, 2014 There is an urgent medical need for improved vaccines with broad serovar coverage and high efficacy against systemic salmonellosis. Subunit vaccines offer excellent safety profiles but require identification of protective antigens, which remains a ...
Dirk eBumann, Bumann, Dirk, Dirk Bumann
core +1 more source