Results 51 to 60 of about 118,445 (283)

Peripheral blood iNKT cells display an activated profile with both increased apoptosis and dysfunction in obesity

Frontiers in Immunology
Obesity is characterized by a chronic low-grade inflammation and, paradoxically, is also associated with immune cells dysfunction. In this study, we analyzed peripheral blood Invariant Natural killer T cells (iNKT) in individuals with or without obesity.
Chloé Wilkin, Nathalie Esser, Nathalie Esser, Cédric Lassence, Marion Bruneteaux, Marjorie Fadeur, Jenny De Flines, Nicolas Paquot, Nicolas Paquot, Jacques Piette, Sylvie Legrand-Poels   +10 more
doaj   +1 more source

Role of Group 1 CD1-restricted T Cells in Infectious Disease

Frontiers in Immunology, 2015
The evolutionarily conserved CD1 family of antigen-presenting molecules presents lipid antigens rather than peptide antigens to T cells. CD1 molecules, unlike classical MHC molecules, display limited polymorphism, making CD1-restricted lipid antigens ...
Sarah eSiddiqui, Lavanya eVisvabharathy, Chyung-Ru eWang   +2 more
doaj   +1 more source

CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system

Experimental and Molecular Medicine, 2023
The cluster of differentiation 1 (CD1) molecule differs from major histocompatibility complex class I and II because it presents glycolipid/lipid antigens. Moreover, the CD1-restricted T cells that recognize these self and foreign antigens participate in
Seohyun Kim, Sumin Cho, Ji Hyung Kim
doaj   +1 more source

Leptospira Lipid A Is a Potent Adjuvant That Induces Sterilizing Immunity against Leptospirosis

Vaccines, 2023
Leptospirosis is a globally significant zoonotic disease. The current inactivated vaccine offers protection against specific serovars but does not provide complete immunity.
Vivek P. Varma, Mohammad Kadivella, Sridhar Kavela, Syed M. Faisal   +3 more
doaj   +1 more source

Molecular recognition of microbial lipid-based antigens by T cells [PDF]

, 2018
The immune system has evolved to protect hosts from pathogens. T cells represent a critical component of the immune system by their engagement in host defence mechanisms against microbial infections.
Shahine, Adam, Le Nours, Jérôme, Gras, Stephanie, dI&I RA-I&I I&I, LS Immunologie, Van Rhijn, Ildiko   +5 more
core   +1 more source

Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients

Frontiers in Immunology, 2019
The lysosome has a key role in the presentation of lipid antigens by CD1 molecules. While defects in lipid antigen presentation and in invariant Natural Killer T (iNKT) cell response were detected in several mouse models of lysosomal storage diseases ...
Catia S. Pereira, Catia S. Pereira, Begoña Pérez-Cabezas, Begoña Pérez-Cabezas, Helena Ribeiro, Helena Ribeiro, Helena Ribeiro, M. Luz Maia, M. Teresa Cardoso, Ana F. Dias, Olga Azevedo, M. Fatima Ferreira, Paula Garcia, Esmeralda Rodrigues, Paulo Castro-Chaves, Esmeralda Martins, Patricio Aguiar, Mercè Pineda, Yasmina Amraoui, Simona Fecarotta, Elisa Leão-Teles, Shenglou Deng, Paul B. Savage, M. Fatima Macedo, M. Fatima Macedo, M. Fatima Macedo   +25 more
doaj   +1 more source

Pollen lipidomics: lipid profiling exposes a notable diversity in 22 allergenic pollen and potential biomarkers of the allergic immune response. [PDF]

PLoS ONE, 2013
BACKGROUND/AIM: Pollen grains are the male gametophytes that deliver sperm cells to female gametophytes during sexual reproduction of higher plants. Pollen is a major source of aeroallergens and environmental antigens.
Mohamed Elfatih H Bashir, Jan Hsi Lui, Ravishankar Palnivelu, Robert M Naclerio, Daphne Preuss   +4 more
doaj   +1 more source

Re-programming mouse liver-resident invariant natural killer T cells for suppressing hepatic and diabetogenic autoimmunity

Nature Communications, 2022
Invariant natural killer T (iNKT) cells are tissue-resident immune cells recognizing lipid antigens. Here the authors find that liver, but not lung nor spleen, iNKT cells alter their transcriptome upon systemic treatment of lipid nanoparticles for the ...
Channakeshava Sokke Umeshappa, Patricia Solé, Jun Yamanouchi, Saswat Mohapatra, Bas G. J. Surewaard, Josep Garnica, Santiswarup Singha, Debajyoti Mondal, Elena Cortés-Vicente, Charlotte D’Mello, Andrew Mason, Paul Kubes, Pau Serra, Yang Yang, Pere Santamaria   +14 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Immunogenicity and antigenicity of synthetic Escherichia coli lipid A [PDF]

Infection and Immunity, 1986
The immunogenicity and antigenicity of synthetic Escherichia coli lipid A (compound 506) and its 1- and 4'-monophosphorylated derivatives (compounds 505 and 504, respectively) and nonphosphorylated derivative (compound 503) were compared with those of bis- and 4'-monophosphorylated natural free lipid A from E. coli.
L, Brade, E T, Rietschel, S, Kusumoto, T, Shiba, H, Brade   +4 more
openaire   +2 more sources