Results 61 to 70 of about 118,445 (283)

Exploring the immunology of parasitism--from surface antigens to the hygiene hypothesis [PDF]

, 2009
Helminth immunology is a field which has changed beyond recognition in the past 30 years, transformed not only by new technologies from cDNA cloning to flow cytometry, but also conceptually as our definition of host immune pathways has matured.
R. M. MAIZELS, Maizels, R M
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Presenting lipid antigens

The Journal of Cell Biology, 2005
Immune cells inspect not just protein but also lipid antigens, thanks to presentation by the MHC relative CD1. Now, results from Peter van den Elzen, Michael Brenner (Harvard Medical School, Boston MA), and colleagues show that immune cells co-opt normal pathways of fat metabolism to deliver ...
openaire   +2 more sources

Enzymatic Synthesis of the Antigen Carrier Lipid

Journal of Biological Chemistry, 1969
Abstract Two enzyme systems which catalyze polyprenol synthesis from Δ3-isopentenyl pyrophosphate and farnesyl pyrophosphate have been extracted from Salmonella newington. One system, which is soluble, yields products of chain length shorter than the 55-carbon isoprenoid antigen carrier lipid.
J G, Christenson, S K, Gross, P W, Robbins   +2 more
openaire   +2 more sources

Altered Lipid Tumor Environment and Its Potential Effects on NKT Cell Function in Tumor Immunity

Frontiers in Immunology, 2019
Natural killer T (NKT) cells are CD1d restricted T cells that mostly recognize lipid antigens. These cells share characteristics with both adaptive and innate immune cells and have multiple immunoregulatory roles.
Shweta Tiwary, Jay A. Berzofsky, Masaki Terabe   +2 more
doaj   +1 more source

Solution structure of a repeated unit of the ABA-1 nematode polyprotein allergen of ascaris reveals a novel fold and two discrete lipid-binding sites [PDF]

, 2011
Parasitic nematode worms cause serious health problems in humans and other animals. They can induce allergic-type immune responses, which can be harmful but may at the same time protect against the infections. Allergens are proteins that trigger allergic
Ball, G., Smith, B.O., Cooper, Alan, Bromek Krystyna, Malcolm W Kennedy, Smith Brian O., Meenan, N.A.G., Bromek, K., Uhrín, D., Uhrin, Dusan, Cooper Alan, Brian O. Smith, Meenan, N., Krystyna Bromek, Bromek, Krystyna, Kennedy, M.W., Ball Graeme, Brian O Smith, Meenan, Nicola A. G., Alan Cooper, Uhrín Dušan, Cooper, A., Kennedy, M., Nicola A. G. Meenan, Malcolm W. Kennedy, Graeme Ball, Nicola A G Meenan, Kennedy, Malcolm W., Meenan Nicola A. G., Dušan Uhrín, Ball, Graeme, Kennedy Malcolm W., Smith, B., Smith, Brian O.   +33 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against Plasmodium falciparum merozoite antigens [PDF]

, 2015
Malaria is a major global cause of deaths and a vaccine is urgently needed.; We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA, and coupled them in different ways using surface plasmon resonance (SPR) and ...
Stanisic, Danielle, Kironde, Fred, Danielle I. Stanisic, Anders, Robin F, Reddy, Sreenivasulu B, Persson, Kristina, Sreenivasulu B. Reddy, Cross, Nadia, Mats Wahlgren, Anders, Robin F., Cross, N, Beeson, James G, Wahlgren, M, Senn, Nicolas, Senn, N, Nicolas Senn, Kristina E.M. Persson, Reddy, SB, Stanisic, DI, Wahlgren, Mats, Nadia Cross, Fred Kironde, Beeson, JG, Persson, KEM, Mueller, Ivo, Reddy, Sreenivasulu B., Ivo Mueller, Peter M. Siba, Kironde, F, Siba, Peter M, Mueller, I, Siba, PM, Stanisic, Danielle I, Stanisic, Danielle I., Persson, Kristina,, Robin F. Anders, James G. Beeson, Siba, Peter M., Persson, Kristina E. M., Lund University., Beeson, James G., Anders, RF   +41 more
core   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source