Results 21 to 30 of about 122,182 (249)

Vaccine approaches for antigen capture by liposomes

Expert Review of Vaccines, 2023
Introduction Liposomes have been used as carriers for vaccine adjuvants and antigens due to their inherent biocompatibility and versatility as delivery vehicles.
Shiqi Zhou, Yuan Luo, Jonathan Lovell
doaj   +1 more source

Induction of Mycobacterium Tuberculosis Lipid-Specific T Cell Responses by Pulmonary Delivery of Mycolic Acid-Loaded Polymeric Micellar Nanocarriers

Frontiers in Immunology, 2018
Mycolic acid (MA), a major lipid component of Mycobacterium tuberculosis (Mtb) cell wall, can be presented by the non-polymorphic antigen presenting molecule CD1b to T cells isolated from Mtb-infected individuals.
Shaobin Shang, Dina Kats, Liang Cao, Eva Morgun, Diana Velluto, Ying He, Qichen Xu, Chyung-Ru Wang, Evan A. Scott, Evan A. Scott, Evan A. Scott, Evan A. Scott   +11 more
doaj   +1 more source

CD1d-lipid antigen recognition by the γδ TCR [PDF]

Nature Immunology, 2013
The T lymphocytes repertoire is divided into two major lineages, αβ and γδ T cells, which are defined by their T cell receptor (TCR) gene-segment usage. To date, the key discoveries on human CD1d restricted T cells have focussed on the type I Natural Killer T cells (NKT) subset that express an invariant TCR α chain (Vα24Jα18) which pairs with a β chain
Uldrich, AP, Le Nours, J, Pellicci, DG, Gherardin, NA, Mcpherson, KG, Lim, RT, Patel, O, Beddoe, T, Gras, S, Rossjohn, J, Godfrey, DI   +10 more
openaire   +3 more sources

Harnessing the Power of Invariant Natural Killer T Cells in Cancer Immunotherapy

Frontiers in Immunology, 2017
Invariant natural killer T (iNKT) cells are a distinct subset of innate-like lymphocytes bearing an invariant T-cell receptor, through which they recognize lipid antigens presented by monomorphic CD1d molecules. Upon activation, iNKT cells are capable of
Melissa Bedard, Mariolina Salio, Vincenzo Cerundolo   +2 more
doaj   +1 more source

Enzymatic Synthesis of the Antigen Carrier Lipid

Journal of Biological Chemistry, 1969
Abstract Two enzyme systems which catalyze polyprenol synthesis from Δ3-isopentenyl pyrophosphate and farnesyl pyrophosphate have been extracted from Salmonella newington. One system, which is soluble, yields products of chain length shorter than the 55-carbon isoprenoid antigen carrier lipid.
J G, Christenson, S K, Gross, P W, Robbins   +2 more
openaire   +2 more sources

An improved preparation of bovine brain proteolipid

Journal of Lipid Research, 1967
An improved preparation of proteolipid from bovine brain white matter is described. The product obtained by repeated acetone precipitation is completely soluble in chloroform-methanol and has a fairly constant composition: 35% protein, 40 ...
Roberto Cavanna, Maurice M. Rapport
doaj   +1 more source

Dual delivery of antigens shows promise

eLife, 2023
The simultaneous delivery of protein and lipid antigens via nanoparticles may help efforts to develop a new vaccine for tuberculosis.
Jose L Luque-García, Rafael Prados-Rosales   +1 more
doaj   +1 more source

The Conventional Nature of Non-MHC-Restricted T Cells

Frontiers in Immunology, 2018
The definition “unconventional T cells” identifies T lymphocytes that recognize non-peptide antigens presented by monomorphic antigen-presenting molecules.
Marco Lepore, Lucia Mori, Gennaro De Libero   +2 more
doaj   +1 more source

Peripheral blood iNKT cells display an activated profile with both increased apoptosis and dysfunction in obesity

Frontiers in Immunology
Obesity is characterized by a chronic low-grade inflammation and, paradoxically, is also associated with immune cells dysfunction. In this study, we analyzed peripheral blood Invariant Natural killer T cells (iNKT) in individuals with or without obesity.
Chloé Wilkin, Nathalie Esser, Nathalie Esser, Cédric Lassence, Marion Bruneteaux, Marjorie Fadeur, Jenny De Flines, Nicolas Paquot, Nicolas Paquot, Jacques Piette, Sylvie Legrand-Poels   +10 more
doaj   +1 more source

Role of natural killer T lymphocytes during helminthic infection

Parasite, 2008
Natural killer (NK)T cells are innate lymphocytes that release important amount of immunoregulatory cytokines (IFN-γ and/or IL-4) shortly after T cell receptor engagement by (glyco)lipid antigens presented by the CD1d molecules.
Faveeuw C., Mallevaey T., Trottein F.
doaj   +1 more source