Results 21 to 30 of about 118,445 (283)
Antigen-presentation of non-peptidic antigens lipid trafficking and loading [PDF]
, 2010 T cells recognize a broad variety of antigens, including peptides, lipids and non-peptidic phosphorylated metabolites. Clarification of the rules rendering non-peptidic molecules immunogenic is essential to understand and to influence the reactions of the immune system to this class of substances in health and disease.
Cavallari, Marco F.
openaire +3 more sources
The CD1 family: serving lipid antigens to T cells since the Mesozoic era [PDF]
Immunogenetics, 2016 Dirk M Zajonc, Zajonc Dirk M
exaly +2 more sources
Buffy Coat Processing Impacts on Monocytes' Capacity to Present Lipid Antigens. [PDF]
Biomedicines, 2023 Buffy Coats, generated from a blood donor’s whole blood bag unit, are commonly used in biomedical research as a source of leukocytes due to the high number of cells that can be recovered from each Buffy Coat.
Mondragão-Rodrigues I, Macedo MF.
europepmc +2 more sources
NKT Cells Contribute to the Control of Microbial Infections
Frontiers in Cellular and Infection Microbiology, 2021 Innate (-like) T lymphocytes such as natural killer T (NKT) cells play a pivotal role in the recognition of microbial infections and their subsequent elimination.
Stefan Vogt +2 more
doaj +1 more source
New synthetic lipid antigens for rapid serological diagnosis of tuberculosis. [PDF]
PLoS One, 2017 BackgroundDuring pulmonary tuberculosis (PTB) antibodies are generated to trehalose esters of mycolic acids which are cell wall lipids of Mycobacterium tuberculosis (Mtb). Attempts have been made to use these complex natural mixtures in serological tests
Jones A +7 more
europepmc +2 more sources
Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens. [PDF]
Nat Commun, 2016 The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus ...
Le Nours J +13 more
europepmc +2 more sources
Frontiers in Immunology, 2020 Methicillin-resistant Staphylococcus aureus (SA) bacteremia is responsible for over 10,000 deaths in the hospital setting each year. Both conventional CD4+ T cells and γδ T cells play protective roles in SA infection through secretion of IFN-γ and IL-17.
Samantha Genardi +9 more
doaj +1 more source
Presentation of Lipid Antigens by CD1 Glycoproteins [PDF]
Current Pharmaceutical Design, 2009 CD1 molecules are a family of non-polymorphic, class I antigen-presenting glycoproteins, which bind and present amphiphilic lipid antigens for recognition to T cells. Two groups of CD1 molecules are involved in presentation of self and foreign lipid antigens: group 1 (CD1a, CD1b and CD1c) and group 2 (CD1d). Crystal structures of CD1a, CD1b and CD1d in
André, Schiefner, Ian A, Wilson
openaire +2 more sources
JCI Insight, 2023 Invariant natural killer T (iNKT) cells act at the interface between lipid metabolism and immunity because of their restriction to lipid antigens presented on CD1d by antigen-presenting cells (APCs).
Suzanne E. Engelen +24 more
doaj +1 more source
Lipid-Reactive T Cells in Immunological Disorders of the Lung
Frontiers in Immunology, 2018 Regulation of T cell-mediated immunity in the lungs is critical for prevention of immune-related lung disorders and for host protection from pathogens.
Seungwon Ryu +5 more
doaj +1 more source