Results 41 to 50 of about 18,685 (221)
eLife, 2015 Group 1 CD1 molecules, CD1a, CD1b and CD1c, present lipid antigens from Mycobacterium tuberculosis (Mtb) to T cells. Mtb lipid-specific group 1 CD1-restricted T cells have been detected in Mtb-infected individuals.
Jie Zhao +6 more
doaj +1 more source
Frontiers in Immunology, 2021 Persistent human papillomavirus (HPV) infections are causative for cervical neoplasia and carcinomas. Despite the availability of prophylactic vaccines, morbidity and mortality induced by HPV are still too high.
Patrick Neckermann +11 more
doaj +1 more source
Location, location, location: the evolutionary history of CD1 genes and the NKR-P1/ligand systems [PDF]
, 2016 CD1 genes encode cell surface molecules that present lipid antigens to various kinds of T lymphocytes of the immune system. The structures of CD1 genes and molecules are like the major histocompatibility complex (MHC) class I system, the loading of ...
Kaufman, Jim, Rogers, Sally L
core +2 more sources
CD1 molecules: Beyond antigen presentation
Molecular ImmunologyCD1 molecules are well known for their role in binding and presenting lipid antigens to mediate the activation of CD1-restricted T cells. However, much less appreciated is the fact that CD1 molecules can have additional "unconventional" roles which impact the activation and functions of CD1-expressing cells, ultimately controlling tissue homeostasis as
Evans, Lauren, Barral, Patricia
openaire +2 more sources
Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients
Frontiers in Immunology, 2019 The lysosome has a key role in the presentation of lipid antigens by CD1 molecules. While defects in lipid antigen presentation and in invariant Natural Killer T (iNKT) cell response were detected in several mouse models of lysosomal storage diseases ...
Catia S. Pereira +25 more
doaj +1 more source
Positive selection of V beta 8+ CD4-8- thymocytes by class I molecules expressed by hematopoietic cells. [PDF]
, 1993 A small subset of T cells of mature phenotype express the alpha/beta T cell receptor, but not CD4 and CD8 coreceptors (alpha/beta double-negative [DN] cells).
Bix, M, Coles, M, RAULET, David H.
core +1 more source
CD1: From Molecules to Diseases [version 1; referees: 3 approved]
F1000Research, 2017 The human cluster of differentiation (CD)1 system for antigen display is comprised of four types of antigen-presenting molecules, each with a distinct functional niche: CD1a, CD1b, CD1c, and CD1d.
D. Branch Moody, Sara Suliman
doaj +1 more source
The Conventional Nature of Non-MHC-Restricted T Cells
Frontiers in Immunology, 2018 The definition “unconventional T cells” identifies T lymphocytes that recognize non-peptide antigens presented by monomorphic antigen-presenting molecules.
Marco Lepore +2 more
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Vaccines, 2023 Spondyloarthropathies (SpA) are a group of chronic inflammatory disorders usually affecting the axial spine and asymmetrical peripheral joints. Strong evidence links genetic and environmental factors to SpA pathogenesis. The HLA-B27 is the most important
Angelica Canossi +5 more
doaj +1 more source
Wellcome Open Research, 2019 Background: Lipid antigens are presented on the surface of cells by the CD1 family of glycoproteins, which have structural and functional similarity to MHC class I molecules.
Maria Shamin +3 more
doaj +1 more source