Results 41 to 50 of about 11,539 (211)

Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients

Frontiers in Immunology, 2019
The lysosome has a key role in the presentation of lipid antigens by CD1 molecules. While defects in lipid antigen presentation and in invariant Natural Killer T (iNKT) cell response were detected in several mouse models of lysosomal storage diseases ...
Catia S. Pereira, Catia S. Pereira, Begoña Pérez-Cabezas, Begoña Pérez-Cabezas, Helena Ribeiro, Helena Ribeiro, Helena Ribeiro, M. Luz Maia, M. Teresa Cardoso, Ana F. Dias, Olga Azevedo, M. Fatima Ferreira, Paula Garcia, Esmeralda Rodrigues, Paulo Castro-Chaves, Esmeralda Martins, Patricio Aguiar, Mercè Pineda, Yasmina Amraoui, Simona Fecarotta, Elisa Leão-Teles, Shenglou Deng, Paul B. Savage, M. Fatima Macedo, M. Fatima Macedo, M. Fatima Macedo   +25 more
doaj   +1 more source

CD1 antigen presentation by human dendritic cells as a target for herpes simplex virus immune evasion.

, 2006
In contrast to MHC molecules, which present peptides, the CD1 molecules have been discovered to present lipid Ags to T cells. CD1-restricted T lymphocytes have been recently associated with resistance to virus infection.
Martin J. Raftery, Stefan H. E. Kaufmann, Raftery, Martin J, Kaufmann, Stefan H. E., Winau, Florian, Raftery, Martin J., Günther Schönrich, Kaufmann, Stefan HE, Ulrich E. Schaible, Schönrich, Günther, Florian Winau, Schaible, Ulrich E, Schaible, Ulrich E.   +12 more
core   +1 more source

CD1: A Singed Cat of the Three Antigen Presentation Systems [PDF]

Archivum Immunologiae et Therapiae Experimentalis, 2017
Contrary to general view that the MHC Class I and II are the kapellmeisters of recognition and response to antigens, there is another big player in that part of immunity, represented by CD1 glycoproteins. In contrast to MHC Class I or II, which present peptides, CD1 molecules present lipids.
Kaczmarek, Radoslaw, Pasciak, Mariola, Szymczak-Kulus, Katarzyna, Czerwinski, Marcin   +3 more
openaire   +2 more sources

The Conventional Nature of Non-MHC-Restricted T Cells

Frontiers in Immunology, 2018
The definition “unconventional T cells” identifies T lymphocytes that recognize non-peptide antigens presented by monomorphic antigen-presenting molecules.
Marco Lepore, Lucia Mori, Gennaro De Libero   +2 more
doaj   +1 more source

The Role of CD1 Gene Polymorphism in the Genetic Susceptibility to Spondyloarthropathies in the Moroccan Population and the Possible Cross-Link with Celiac Disease

Vaccines, 2023
Spondyloarthropathies (SpA) are a group of chronic inflammatory disorders usually affecting the axial spine and asymmetrical peripheral joints. Strong evidence links genetic and environmental factors to SpA pathogenesis. The HLA-B27 is the most important
Angelica Canossi, Khadija Oumhani, Tiziana Del Beato, Pierluigi Sebastiani, Alessia Colanardi, Anna Aureli   +5 more
doaj   +1 more source

The lipid transfer protein Saposin B does not directly bind CD1d for lipid antigen loading [version 2; peer review: 3 approved]

Wellcome Open Research, 2019
Background: Lipid antigens are presented on the surface of cells by the CD1 family of glycoproteins, which have structural and functional similarity to MHC class I molecules.
Maria Shamin, Tomasz H. Benedyk, Stephen C. Graham, Janet E. Deane   +3 more
doaj   +1 more source

Antigen-presentation of non-peptidic antigens lipid trafficking and loading [PDF]

, 2010
T cells recognize a broad variety of antigens, including peptides, lipids and non-peptidic phosphorylated metabolites. Clarification of the rules rendering non-peptidic molecules immunogenic is essential to understand and to influence the reactions of ...
Cavallari, Marco F.
core   +1 more source

Lipid-Reactive T Cells in Immunological Disorders of the Lung

Frontiers in Immunology, 2018
Regulation of T cell-mediated immunity in the lungs is critical for prevention of immune-related lung disorders and for host protection from pathogens.
Seungwon Ryu, Seungwon Ryu, Joon Seok Park, Hye Young Kim, Hye Young Kim, Ji Hyung Kim   +5 more
doaj   +1 more source

CD1b Tetramers Broadly Detect T Cells That Correlate With Mycobacterial Exposure but Not Tuberculosis Disease State

Frontiers in Immunology, 2020
The non-polymorphic nature of CD1 proteins creates a situation in which T cells with invariant T cell receptors (TCRs), like CD1d-specific NKT cells, are present in all humans.
Kattya Lopez, Kattya Lopez, Sarah K. Iwany, Sara Suliman, Josephine F. Reijneveld, Josephine F. Reijneveld, Tonatiuh A. Ocampo, Judith Jimenez, Roger Calderon, Leonid Lecca, Megan B. Murray, D. Branch Moody, Ildiko Van Rhijn, Ildiko Van Rhijn   +13 more
doaj   +1 more source

Synthetic O‐Polysaccharide Backbone Units for a Single Antigen Vaccine Against Two Major Non‐Typhoidal Salmonella Serovars

Angewandte Chemie International Edition, EarlyView.
A modular strategy was developed to synthesize tri‐, hexa‐, and nona‐saccharides representing repeating units of the conserved O‐polysaccharide backbone of Salmonella. Conjugates of these glycans to bacteriophage Qβ induced strong IgG responses in mice and rabbits. Antibodies elicited recognized native O‐polysaccharides and conferred protection against
Xingling Pan, Changxin Huo, Soham Maity, Herbert Kavunja, Rachel Moszyk, Cameron Talbot, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source