Results 31 to 40 of about 11,539 (211)
Endogenous and Exogenous CD1-Binding Glycolipids [PDF]
, 2011 In the same way that peptide antigens are presented by major histocompatibility complex (MHC) molecules, glycolipid antigens can also activate the immune response via binding to CD1 proteins on antigen-presenting cells (APCs) and stimulate CD1-restricted
Ashna A. Khan +3 more
core +1 more source
CD1 displays its own negative regulators
, 2023 After two decades of the study of lipid antigens that activate CD1-restricted T cells, new studies show how autoreactive αβ T-cell receptors (TCRs) can directly recognize the outer surface of CD1 proteins in ways that are lipid-agnostic.
Adam Shahine +7 more
core +1 more source
Polyantigenic Interferon-γ Responses are Associated with Protection from TB Among HIV-Infected Adults with Childhood BCG Immunization. [PDF]
, 2011 Surrogate immunologic markers for natural and vaccine-mediated protection against tuberculosis (TB) have not been identified. HIV-infected adults with childhood BCG immunization entering the placebo arm of the DarDar TB vaccine trial in Dar es Salaam ...
Horsburgh, C Robert +42 more
core +1 more source
Frontiers in Immunology, 2015 Since initial reports, more than 25 years ago, that T cells recognise lipids in the context on non-polymorphic CD1 molecules, our understanding of antigen presentation to non-peptide specific T cell populations has deepened.
Mariolina eSalio, Vincenzo eCerundolo
doaj +1 more source
Determination of cellular lipids bound to human CD1d molecules. [PDF]
PLoS ONE, 2009 CD1 molecules are glycoproteins that present lipid antigens at the cell surface for immunological recognition by specialized populations of T lymphocytes.
Daryl Cox +7 more
doaj +1 more source
CD1-Restricted T Cells During Persistent Virus Infections: “Sympathy for the Devil”
Frontiers in Immunology, 2018 Some of the clinically most important viruses persist in the human host after acute infection. In this situation, the host immune system and the viral pathogen attempt to establish an equilibrium. At best, overt disease is avoided. This attempt may fail,
Günther Schönrich, Martin J. Raftery
doaj +1 more source
Nonclassical MHC Ib-restricted CD8+ T Cells Recognize Mycobacterium tuberculosis-Derived Protein Antigens and Contribute to Protection Against Infection. [PDF]
PLoS Pathogens, 2016 MHC Ib-restricted CD8+ T cells have been implicated in host defense against Mycobacterium tuberculosis (Mtb) infection. However, the relative contribution of various MHC Ib-restricted T cell populations to anti-mycobacterial immunity remains elusive.
Shaobin Shang +4 more
doaj +1 more source
eLife, 2015 Group 1 CD1 molecules, CD1a, CD1b and CD1c, present lipid antigens from Mycobacterium tuberculosis (Mtb) to T cells. Mtb lipid-specific group 1 CD1-restricted T cells have been detected in Mtb-infected individuals.
Jie Zhao +6 more
doaj +1 more source
Frontiers in Immunology, 2021 Persistent human papillomavirus (HPV) infections are causative for cervical neoplasia and carcinomas. Despite the availability of prophylactic vaccines, morbidity and mortality induced by HPV are still too high.
Patrick Neckermann +11 more
doaj +1 more source
Editorial: Community series in the role of CD1- and MR1-restricted T cells in immunity and disease, volume II [PDF]
Frontiers in ImmunologyKazuya Iwabuchi, Luc Van Kaer
doaj +2 more sources