Results 31 to 40 of about 18,685 (221)
Clinical and Developmental Immunology, 2011 Group I CD1 (CD1a, CD1b, and CD1c) glycoproteins expressed on immature and mature dendritic cells present nonpeptide antigens (i.e., lipid or glycolipid molecules mainly of microbial origin) to T cells.
Angelo Aquino +6 more
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CD1-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity
Journal of Immunology Research, 2016 Lipid-specific T cells comprise a group of T cells that recognize lipids bound to the MHC class I-like CD1 molecules. There are four isoforms of CD1 that are expressed at the surface of antigen presenting cells and therefore capable of presenting lipid ...
Catia S. Pereira, M. Fatima Macedo
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Mechanisms and Consequences of Antigen Presentation by CD1 [PDF]
Trends in Immunology, 2016 The CD1 proteins are a family of non-polymorphic and MHC class I-related molecules that present lipid antigens to subsets of T lymphocytes with innate- or adaptive-like immune functions. Recent studies have provided new insight into the identity of immunogenic CD1 antigens and the mechanisms that control the generation and loading of these antigens ...
Luc, Van Kaer, Lan, Wu, Sebastian, Joyce
openaire +2 more sources
Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function [PDF]
, 2018 MHC class I-like CD1 molecules have evolved to present lipid-based antigens to T cells. Differences in the antigen-binding clefts of the CD1 family members determine the conformation and size of the lipids that are presented, although the factors that ...
Bradbury +22 more
core +4 more sources
Frontiers in Immunology, 2015 Since initial reports, more than 25 years ago, that T cells recognise lipids in the context on non-polymorphic CD1 molecules, our understanding of antigen presentation to non-peptide specific T cell populations has deepened.
Mariolina eSalio, Vincenzo eCerundolo
doaj +1 more source
Determination of cellular lipids bound to human CD1d molecules. [PDF]
PLoS ONE, 2009 CD1 molecules are glycoproteins that present lipid antigens at the cell surface for immunological recognition by specialized populations of T lymphocytes.
Daryl Cox +7 more
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CD1-Restricted T Cells During Persistent Virus Infections: “Sympathy for the Devil”
Frontiers in Immunology, 2018 Some of the clinically most important viruses persist in the human host after acute infection. In this situation, the host immune system and the viral pathogen attempt to establish an equilibrium. At best, overt disease is avoided. This attempt may fail,
Günther Schönrich, Martin J. Raftery
doaj +1 more source
CD1b Tetramers Bind \(\alpha \beta\) T Cell Receptors to Identify a Mycobacterial Glycolipid-Reactive T Cell Repertoire in Humans [PDF]
, 2013 Microbial lipids activate T cells by binding directly to CD1 and T cell receptors (TCRs) or by indirect effects on antigen-presenting cells involving induction of lipid autoantigens, CD1 transcription, or cytokine release. To distinguish among direct and
Altman, John D. +14 more
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Nonclassical MHC Ib-restricted CD8+ T Cells Recognize Mycobacterium tuberculosis-Derived Protein Antigens and Contribute to Protection Against Infection. [PDF]
PLoS Pathogens, 2016 MHC Ib-restricted CD8+ T cells have been implicated in host defense against Mycobacterium tuberculosis (Mtb) infection. However, the relative contribution of various MHC Ib-restricted T cell populations to anti-mycobacterial immunity remains elusive.
Shaobin Shang +4 more
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Non-classical immunology. Meeting Report [PDF]
, 2001 This large annual immunology meeting covered a wide range of subjects from biochemical protein characterizations to cell biology and the study of complex disease pathologies.
Allen, RL
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