Results 21 to 30 of about 11,539 (211)

Presentation of Lipid Antigens by CD1 Glycoproteins [PDF]

Current Pharmaceutical Design, 2009
CD1 molecules are a family of non-polymorphic, class I antigen-presenting glycoproteins, which bind and present amphiphilic lipid antigens for recognition to T cells. Two groups of CD1 molecules are involved in presentation of self and foreign lipid antigens: group 1 (CD1a, CD1b and CD1c) and group 2 (CD1d). Crystal structures of CD1a, CD1b and CD1d in
André, Schiefner, Ian A, Wilson
openaire   +2 more sources

Inhibition of CD1 Antigen Presentation by Human Cytomegalovirus [PDF]

Journal of Virology, 2008
ABSTRACTThe betaherpesvirus human cytomegalovirus (HCMV) encodes several molecules that block antigen presentation by the major histocompatibility complex (MHC) proteins. Humans also possess one other family of antigen-presenting molecules, the CD1 family; however, the effect of HCMV on CD1 expression is unknown.
Raftery, M., Hitzler, M., Winau, F., Giese, T., Plachter, B., Kaufmann, S., Schönrich, G.   +6 more
openaire   +3 more sources

Structural Dynamics of the Lipid Antigen-Binding Site of CD1d Protein

Biomolecules, 2020
CD1 molecules present lipid antigens to T-cells in early stages of immune responses. Whereas CD1‒lipid‒T-cell receptors interactions are reasonably understood, molecular details on initial trafficking and loading of lipids onto CD1 proteins are less ...
Bruno Cuevas-Zuviría, Marina Mínguez-Toral, Araceli Díaz-Perales, María Garrido-Arandia, Luis F. Pacios   +4 more
doaj   +1 more source

A novel self-lipid antigen targets human T cells against CD1c(+) leukemias [PDF]

, 2014
T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects.
Lepore, Marco, Locatelli, Franco, Giulia Casorati, Paul Jenö, Chengfeng Xia, Consonni, Michela, S. R. Gundimeda, P. Jeno, Daniela Montagna, C. Bonini, Alessandra Forcina, G. Casorati, Claudia de Lalla, Franco Locatelli, Sansano, Sebastiano, Bonini, Chiara, Piccolo, Francesco, Xia, Chengfeng, Z. Li, P. Dellabona, Garavaglia, Claudio, H. Gsellinger, F. Piccolo, de Lalla, Claudia, Paolo Dellabona, G. Ni, F. Ciceri, Gundimeda, S. Ramanjaneyulu, Heiko Gsellinger, Häussinger, Daniel, Daniel Häussinger, Scelfo, Andrea, L. Mori, C. Garavaglia, Gennaro De Libero, A. Bondanza, Michela Consonni, Sebastiano Sansano, A. Forcina, Ciceri, Fabio, Jenö, Paul, Fabio Ciceri, M. Lepore, Attilio Bondanza, Gsellinger, Heiko, De Libero, Gennaro, S. Sansano, Bondanza, Attilio, Casorati, Giulia, D. Haussinger, Marco Lepore, C. de Lalla, G. De Libero, M. Consonni, Guanghui Ni, Lucia Mori, Li, Zhiyuan, Zhiyuan Li, Montagna, Daniela, Forcina, Alessandra, Andrea Scelfo, Mori, Lucia, S. Ramanjaneyulu Gundimeda, Chiara Bonini, Claudio Garavaglia, A. Scelfo, Francesco Piccolo, Ni, Guanghui, C. Xia, Dellabona, Paolo   +69 more
core   +1 more source

24780 Investigating the role of mycobacterial lipid antigens and CD1-restricted T cells in host-protective tuberculosis immunity using a guinea pig model

Journal of Clinical and Translational Science, 2021
IMPACT: Examining lipid immunity for Mycobacterium tuberculosis in a translatable Guinea pig model may serve as a critical foundation for the creation of an efficacious human lipid based vaccine against tuberculosis.
Macallister Harris, James Dilisio, Hadley Gary, Edward Chan, D. Branch Moody, Brendan Podell   +5 more
doaj   +1 more source

Group 1 CD1-restricted T cells contribute to control of systemic Staphylococcus aureus infection.

PLoS Pathogens, 2020
Staphylococcus aureus (SA) is the causative agent of both skin/soft tissue infections as well as invasive bloodstream infections. Though vaccines have been developed to target both humoral and T cell-mediated immune responses against SA, they have ...
Lavanya Visvabharathy, Samantha Genardi, Liang Cao, Ying He, Francis Alonzo, Evgeny Berdyshev, Chyung-Ru Wang   +6 more
doaj   +1 more source

Assessing the response of T cells to "Mycobacterium tuberculosis" lipids [PDF]

, 2008
Most vaccines used nowadays are created using inactivated or attenuated compounds from micro-organisms. Advances in basic immunology and molecular biology opened the gate for consequent improvement of vaccination strategies.
Collmann, Anthony
core   +1 more source

Separate Pathways for Antigen Presentation by CD1 Molecules [PDF]

Immunity, 1999
The ability to sample relevant intracellular compartments is necessary for effective antigen presentation. To detect peptide antigens, MHC class I and II molecules differentially sample cytosolic and endosomal compartments. CD1 constitutes another lineage of lipid antigen-presenting molecules.
Sugita, Masahiko, Grant, Ethan P, van Donselaar, Elly, Hsu, Victor W, Rogers, Rick A, Peters, Peter J, Brenner, Michael B   +6 more
openaire   +2 more sources

Diversification of CD1 molecules shapes lipid antigen selectivity [PDF]

Molecular Biology and Evolution, 2020
Abstract Molecular studies of host-pathogen evolution have largely focused on the consequences of variation at protein-protein interaction surfaces. The potential for other microbe-associated macromolecules to promote arms race dynamics with host factors remains unclear.
Nicole M. Paterson, Hussein Al-Zubieri, Matthew F. Barber   +2 more
openaire   +3 more sources

Structural requirements for antigen presentation by mouse CD1 [PDF]

Proceedings of the National Academy of Sciences, 2000
The structural basis for the T cell response to glycolipid antigens (Ags) remains poorly understood. T lymphocytes autoreactive for mouse CD1 (mCD1.1) or reactive for the glycosphingolipid αgalactosylceramide (α-GalCer) presented by mCD1.1 have been described previously.
Burdin N, Brossay L, Degano M, Iijima H, Gui M, Wilson IA, Kronenberg M   +6 more
openaire   +2 more sources