Results 1 to 10 of about 6,557 (145)

Virus-Mediated Suppression of the Antigen Presentation Molecule MR1 [PDF]

Cell Reports, 2020
Summary: The antigen-presenting molecule MR1 presents microbial metabolites related to vitamin B2 biosynthesis to mucosal-associated invariant T cells (MAIT cells).
Brian P Mcsharry, Hamish E G Mcwilliam, Caroline L Ashley   +2 more
exaly   +9 more sources

Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs

Frontiers in Oncology
BackgroundMajor histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the context of host responses to bacterial infection. MR1-
Jeremy M Raynes, Joseph Dukes, Besra Gurdyal S   +2 more
exaly   +6 more sources

IFNγ regulates MR1 transcription and antigen presentation [PDF]

Frontiers in Immunology
IntroductionAntigen presentation molecules play key roles in T cell immunity. Multiple complementary pathways are known to regulate classical MHC-I molecules at transcriptional, translational, and post-translational levels.
Megan E. Huber, Megan E. Huber, Emily A. Larson, Taylor N. Lust, Chelsea M. Heisler, Melanie J. Harriff, Melanie J. Harriff, Melanie J. Harriff   +7 more
doaj   +4 more sources

Protocol for MR1-ligand cross-linking to discover metabolite antigens by proteomics [PDF]

STAR Protocols
Summary: Here, we present a protocol for the discovery of MR1-bound metabolite ligands by stabilizing Schiff base interactions between MR1 and its ligands.
Hannah Thomas, Garry Dolton, Lucia F. Cardo, Nicola Ternette, Andrew K. Sewell, Thierry Schmidlin   +5 more
doaj   +2 more sources

MR1-dependent antigen presentation [PDF]

Seminars in Cell and Developmental Biology, 2018
MR1 is a non-classical class I molecule that is highly conserved among mammals. Though discovered in 1995, only recently have MR1 ligands and antigens for MR1-restricted T cells been described. Unlike the traditional class I molecules HLA-A, -B, and -C, little MR1 is on the cell surface.
Elham Karamooz, Melanie J Harriff, David M Lewinsohn   +2 more
exaly   +3 more sources

Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation

Frontiers in Immunology, 2023
IntroductionThe antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to present bacterially derived metabolites of vitamin B2 biosynthesis to mucosal-associated invariant T-cells (MAIT cells ...
Stanton Richard J, Fielding Ceri A, Fairlie David P   +2 more
exaly   +3 more sources

Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells

Scientific Reports, 2022
MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early effector responses to microbial infection.
Haihong Jin, Nicole A. Ladd, Andrew M. Peev, Gwendolyn M. Swarbrick, Meghan Cansler, Megan Null, Christopher T. Boughter, Curtis McMurtrey, Aaron Nilsen, Karen M. Dobos, William H. Hildebrand, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff   +14 more
doaj   +3 more sources

Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation

Communications Biology, 2022
MR1-restricted T cells have been implicated in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen presentation molecules, evidence supports multiple, complementary MR1 antigen presentation pathways.
Corinna A. Kulicke, Gwendolyn M. Swarbrick, Nicole A. Ladd, Meghan Cansler, Megan Null, Aneta Worley, Chance Lemon, Tania Ahmed, Joshua Bennett, Taylor N. Lust, Chelsea M. Heisler, Megan E. Huber, Jason R. Krawic, Laurisa M. Ankley, Savannah K. McBride, Fikadu G. Tafesse, Andrew J. Olive, William H. Hildebrand, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff   +21 more
doaj   +3 more sources

Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens [PDF]

eLife
Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that can be sensed by T cells, which are essential for the control of infection. In comparison to viral infections, Mtb antigens are relatively limited and hence, challenging to sample ...
Se-Jin Kim, Jessie C Peterson, Andrew J Olive, Fikadu G Tafesse, Corinna A Kulicke, Elham Karamooz, David Lewinsohn   +6 more
doaj   +2 more sources

Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries

Frontiers in Immunology, 2020
Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors (TCR) and MR1 are highly conserved among mammals, suggesting an important ...
Alexandra J Corbett, Wael Awad, Huimeng Wang   +2 more
exaly   +3 more sources