Results 1 to 10 of about 27,223 (192)

Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells. [PDF]

PLoS Pathogens, 2016
Mucosal-Associated Invariant T (MAIT) cells, present in high frequency in airway and other mucosal tissues, have Th1 effector capacity positioning them to play a critical role in the early immune response to intracellular pathogens, including ...
Melanie J Harriff, Elham Karamooz, Ansen Burr, Wilmon F Grant, Elizabeth T Canfield, Michelle L Sorensen, Luis F Moita, David M Lewinsohn   +7 more
doaj   +6 more sources

Protocol for MR1-ligand cross-linking to discover metabolite antigens by proteomics [PDF]

STAR Protocols
Summary: Here, we present a protocol for the discovery of MR1-bound metabolite ligands by stabilizing Schiff base interactions between MR1 and its ligands.
Hannah Thomas, Garry Dolton, Lucia F. Cardo, Nicola Ternette, Andrew K. Sewell, Thierry Schmidlin   +5 more
doaj   +2 more sources

Virus-Mediated Suppression of the Antigen Presentation Molecule MR1

Cell Reports, 2020
Summary: The antigen-presenting molecule MR1 presents microbial metabolites related to vitamin B2 biosynthesis to mucosal-associated invariant T cells (MAIT cells).
Brian P Mcsharry, Carolyn Samer, Hamish E G Mcwilliam   +2 more
exaly   +3 more sources

IFNγ regulates MR1 transcription and antigen presentation [PDF]

Frontiers in Immunology
IntroductionAntigen presentation molecules play key roles in T cell immunity. Multiple complementary pathways are known to regulate classical MHC-I molecules at transcriptional, translational, and post-translational levels.
Megan E. Huber, Megan E. Huber, Emily A. Larson, Taylor N. Lust, Chelsea M. Heisler, Melanie J. Harriff, Melanie J. Harriff, Melanie J. Harriff   +7 more
doaj   +2 more sources

Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens [PDF]

eLife
Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that can be sensed by T cells, which are essential for the control of infection. In comparison to viral infections, Mtb antigens are relatively limited and hence, challenging to sample ...
Se-Jin Kim, Jessie C Peterson, Andrew J Olive, Fikadu G Tafesse, Corinna A Kulicke, Elham Karamooz, David Lewinsohn   +6 more
doaj   +2 more sources

MR1-ligand cross-linking identifies vitamin B6 metabolites as TCR-reactive antigens [PDF]

Cell Reports: Methods
Summary: Major histocompatibility complex class I-related protein 1 (MR1) plays a central role in the immune recognition of infected cells and can mediate T cell detection of cancer. Knowledge of the nature of the ligands presented by MR1 is still sparse
Thierry Schmidlin, Enas Behiry, Hannah Thomas, Garry Dolton, Fabio Marino, Samiul Hasan, Magdalena von Essen, Rose M. Gathungu, Barbara A. Steigenberger, Hayden Selvadurai, Joseph Dukes, Paul E. Brennan, Owen B. Spiller, Jonathan D. Silk, Andrew K. Sewell, Nicola Ternette   +15 more
doaj   +2 more sources

Flavin and deazaflavin biosynthesis in mycobacteria: relevance to physiology, implications for drug discovery, MR-1 antigenicity, and vaccine development [PDF]

Frontiers in Immunology
Flavin and deazaflavin biosynthesis are highly conserved pathways in mycobacteria, including in Mycobacterium tuberculosis (M.tb). Flavin biosynthesis on one hand is required to produce FMN and FAD, two essential cofactors required to support the flavin ...
Nurudeen Oketade, Melissa D. Chengalroyen, Dylan Kain, David M. Lewinsohn, David M. Lewinsohn, Karen M. Dobos   +5 more
doaj   +2 more sources

Two-pore channels in MR1-dependent presentation of Mycobacterium tuberculosis infection. [PDF]

PLoS Pathogens
MR1 is a ubiquitously expressed MHC-Ib molecule that presents microbial metabolites to MR1-restricted T cells, but there are differences in the antigen presentation pathway of an intracellular microbe compared to exogenously delivered antigen.
Elham Karamooz, Se-Jin Kim, Jessie C Peterson, Allison E Tammen, Shogo Soma, Aviva C R Soll, Erin W Meermeier, Sharon Khuzwayo, David M Lewinsohn   +8 more
doaj   +2 more sources

Molecular recognition of natural compounds by MR1 and their implication in MAIT cell activation elucidated through McMD-based dynamic docking simulations [PDF]

Scientific Reports
Major histocompatibility complex class I-related protein 1 (MR1), presents bacteria-derived ligands to T cell receptors (TCRs) as antigens as a defense against bacterial infections through activation of mucosal-associated invariant T cells (MAIT cells ...
Gert-Jan Bekker, Mitsugu Araki, Kanji Oshima, Yasushi Okuno, Narutoshi Kamiya   +4 more
doaj   +2 more sources

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

Nature Communications, 2016
Mucosal-associated invariant T (MAIT) cells sense riboflavin biosynthetic intermediate antigens with a semi-invariant MR1-restricted T-cell receptor (TCR). Here the authors identify a new MR1-restricted TCR that senses cells infected with S.
Erin W Meermeier, Andrew K Sewell, Alexandra J Corbett   +2 more
exaly   +2 more sources