Results 1 to 10 of about 6,847 (112)

Virus-Mediated Suppression of the Antigen Presentation Molecule MR1

Cell Reports, 2020
Summary: The antigen-presenting molecule MR1 presents microbial metabolites related to vitamin B2 biosynthesis to mucosal-associated invariant T cells (MAIT cells).
Jose A. Villadangos, Caroline L Ashley, Paul R Kinchington   +2 more
exaly   +3 more sources

Sorting endosomes play key roles in presentation of Mycobacterium tuberculosis-derived ligands to MAIT cells [PDF]

Scientific Reports
The immune system has developed specialized mechanisms to recognize intracellular pathogens such as Mycobacterium tuberculosis (Mtb). Major Histocompatibility Complex Class I-Related protein 1 (MR1) is a conserved nonclassical antigen presenting molecule
Allison E. Tammen, Jessie C. Peterson, Aneta Worley, David M. Lewinsohn, Elham Karamooz   +4 more
doaj   +2 more sources

Protocol for MR1-ligand cross-linking to discover metabolite antigens by proteomics [PDF]

STAR Protocols
Summary: Here, we present a protocol for the discovery of MR1-bound metabolite ligands by stabilizing Schiff base interactions between MR1 and its ligands.
Hannah Thomas, Garry Dolton, Lucia F. Cardo, Nicola Ternette, Andrew K. Sewell, Thierry Schmidlin   +5 more
doaj   +2 more sources

Human neonatal MR1T cells have more diverse TCR repertoires but reduced bacterial recognition than adult MR1T cells [PDF]

Nature Communications
Bacterial sepsis is a leading cause of neonatal mortality. Pro-inflammatory MR1-restricted T (MR1T) cells may help protect from sepsis by recognizing bacterial pathogens producing the canonical MR1 antigen 5-OP-RU.
Dylan Kain, Wael Awad, G. W. McElfresh, Meghan Cansler, Gwendolyn M. Swarbrick, Kean Chan Yew Poa, Conor McNeice, Gregory Boggy, Katherine H. Rott, Megan D. Null, David M. Lewinsohn, Jamie Rossjohn, Benjamin N. Bimber, Deborah A. Lewinsohn   +13 more
doaj   +2 more sources

Characterization of Tumor-Infiltrating Lymphocyte-Derived Atypical TCRs Recognizing Breast Cancer in an MR1-Dependent Manner

Cells
The MHC class I-related 1 (MR1) molecule is a non-polymorphic antigen-presenting molecule that presents several metabolites to MR1-restricted T cells, including mucosal-associated invariant T (MAIT) cells.
Abdul Hayee, Tatsuhiko Ozawa, Hiroshi Hamana   +2 more
exaly   +3 more sources

Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens [PDF]

eLife
Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that can be sensed by T cells, which are essential for the control of infection. In comparison to viral infections, Mtb antigens are relatively limited and hence, challenging to sample ...
Se-Jin Kim, Jessie C Peterson, Andrew J Olive, Fikadu G Tafesse, Corinna A Kulicke, Elham Karamooz, David Lewinsohn   +6 more
doaj   +2 more sources

Recognition of MR1-antigen complexes by TCR Vγ9Vδ2

Frontiers in Immunology
The TCR-mediated activation of T cells expressing the TCR Vγ9Vδ2 relies on an innate-like mechanism involving the butyrophilin 3A1, 3A2 and 2A1 molecules and phospho-antigens, without the participation of classical antigen-presenting molecules.
José Pedro Loureiro, Alessandro Vacchini, Giuliano Berloffa, Jan Devan, Verena Schaefer, Vladimir Nosi, Rodrigo Colombo, Aisha Beshirova, Giulia Montanelli, Benedikt Meyer, Timothy Sharpe, Andrew Chancellor, Mike Recher, Lucia Mori, Gennaro De Libero   +14 more
exaly   +3 more sources

Flavin and deazaflavin biosynthesis in mycobacteria: relevance to physiology, implications for drug discovery, MR-1 antigenicity, and vaccine development [PDF]

Frontiers in Immunology
Flavin and deazaflavin biosynthesis are highly conserved pathways in mycobacteria, including in Mycobacterium tuberculosis (M.tb). Flavin biosynthesis on one hand is required to produce FMN and FAD, two essential cofactors required to support the flavin ...
Nurudeen Oketade, Melissa D. Chengalroyen, Dylan Kain, David M. Lewinsohn, David M. Lewinsohn, Karen M. Dobos   +5 more
doaj   +2 more sources

Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation

Frontiers in Immunology, 2023
IntroductionThe antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to present bacterially derived metabolites of vitamin B2 biosynthesis to mucosal-associated invariant T-cells (MAIT cells ...
Caroline L. Ashley, Brian P. McSharry, Brian P. McSharry, Hamish E. G. McWilliam, Hamish E. G. McWilliam, Richard J. Stanton, Ceri A. Fielding, Rommel A. Mathias, Rommel A. Mathias, David P. Fairlie, James McCluskey, Jose A. Villadangos, Jose A. Villadangos, Jamie Rossjohn, Jamie Rossjohn, Allison Abendroth, Barry Slobedman   +16 more
doaj   +1 more source

MR1 deficiency enhances IL-17-mediated allergic contact dermatitis

Frontiers in Immunology, 2023
Major histocompatibility complex (MHC) class Ib molecules present antigens to subsets of T cells primarily involved in host defense against pathogenic microbes and influence the development of immune-mediated diseases.
Naoya Imahashi, Naoya Imahashi, Masashi Satoh, Masashi Satoh, Emanuela Clemente, Emanuela Clemente, Kazuhisa Yoshino, Mario Di Gioacchino, Mario Di Gioacchino, Kazuya Iwabuchi, Kazuya Iwabuchi   +10 more
doaj   +1 more source