Results 41 to 50 of about 8,186 (190)

MR1 overexpression correlates with poor clinical prognosis in glioma patients

, 2021
Background: Glioblastoma is the most common adult primary brain tumor with near-universal fatality. Major histocompatibility complex (MHC) class I molecules are important mediators of CD8 activation and can be downregulated by cancer cells to escape ...
Brutkiewicz, Randy R., Bam, Marpe, Priya, Raj, Ong, Irene, Kubica, Phillip, Liu, Peng, Lara-Velazquez, Montserrat, Dey, Mahua, Siraj, Seema, Salamat, Shahriar   +9 more
core   +1 more source

Microbiota of MR1 deficient mice confer resistance against Clostridium difficile infection.

PLoS ONE, 2019
Clostridium difficile (Cd) infection (CDI) typically occurs after antibiotic usage perturbs the gut microbiota. Mucosa-associated invariant T cells (MAIT) are found in the gut and their development is dependent on Major histocompatibility complex-related
Ashley D Smith, Elissa D Foss, Irma Zhang, Jessica L Hastie, Nicole P Giordano, Lusine Gasparyan, Lam Phuc VinhNguyen, Alyxandria M Schubert, Deepika Prasad, Hannah L McMichael, Jinchun Sun, Richard D Beger, Vahan Simonyan, Siobhán C Cowley, Paul E Carlson   +14 more
doaj   +1 more source

The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites. [PDF]

J Exp Med
MHC class I-related protein (MR1) presents vitamin B-based antigens (Ags) to mucosal-associated invariant T (MAIT) cells. While microbial riboflavin (RF) precursors are well-documented MR1 ligands, it is unclear whether host-generated RF catabolites ...
Abdelaal MR, Deng J, McInerney MP, Ito E, Purcell AW, Yamasaki S, Villadangos JA, McWilliam HEG, Gherardin NA, Rossjohn J, Awad W.   +10 more
europepmc   +2 more sources

Ligand-dependent downregulation of MR1 cell surface expression [PDF]

, 2020
The antigen-presenting molecule MR1 presents riboflavin-based metabolites to Mucosal-Associated Invariant T (MAIT) cells. While MR1 egress to the cell surface is ligand-dependent, the ability of small-molecule ligands to impact on MR1 cellular ...
Awad, W, Liam R. Cox, Kulicke, C, Martens, Anne W. J., Martens, Anne W.J., Corinna Kulicke, Judith V. Hobrath, Besra, Gurdyal S., Awad, Wael, Hobrath, Judith V., Besra, Gurdyal, Claudia Gonzalez-Lopez, Martens, Anne, Cerundolo, Vincenzo, Anne W. J. Martens, Hobrath, Judith, Mariolina Salio, Salio, Mariolina, Kulicke, Corinna, Dominic Waithe, Gurdyal S. Besra, Cerundolo, V, Cox, Liam, David M. Lewinsohn, Hobrath, JV, Waithe, D, Besra, GS, Lewinsohn, DM, Martens, AWJ, Lewinsohn, David M., Gonzalez-Lopez, C, Rossjohn, J, Natacha Veerapen, Jamie Rossjohn, Veerapen, Natacha, Gonzalez-Lopez, Claudia, Vincenzo Cerundolo, Salio, M, Besra, Del; id_orcid, Cox, Liam; id_orcid, Veerapen, N, Rossjohn, Jamie, Cox, LR, Lewinsohn, David, Waithe, Dominic, Wael Awad, Cox, Liam R.   +46 more
core   +1 more source

Generation of MR1-Restricted T Cell Clones by Limiting Dilution Cloning of MR1 Tetramer+ Cells [PDF]

, 2019
Tetramers are a powerful tool for identification of T cell subsets that are restricted by specific antigen presenting molecules and their cognate antigens. The generation of T cell clones from specific T cell subsets allows for further investigation of the phenotype and function of these cells.
Meghan, Cansler, Megan, Null, Erin, Meermeier, Gwendolyn, Swarbrick, David, Lewinsohn, Melanie, Harriff   +5 more
openaire   +2 more sources

Flight of the dragons: a global review of migration in Odonata

Biological Reviews, EarlyView.
ABSTRACT Insects are the most abundant and ecologically important animal migrants. Yet, we know relatively little about the patterns and processes underlying insect migration. Dragonflies (Anisoptera) and damselflies (Zygoptera) comprise the ancient insect order Odonata, whose ancestors were the first organisms to fly on Earth.
Johanna S.U. Hedlund, Myles Menz, Jason W. Chapman, Alexander Hayward   +3 more
wiley   +1 more source

Omics GWAS: A Multi‐Omics Integrative Analysis Platform for Genome‐Wide Association Studies

Med Research, EarlyView.
ABSTRACT With the rapid advancement of genome‐wide association studies (GWAS), downstream analyses of GWAS data have become essential for elucidating the genetic mechanisms that underlie complex diseases. However, current post‐GWAS analyses face numerous challenges, including heterogeneous data formats, challenges in multi‐omics integration, and ...
Xu Zhang, Kailai Li, Yasi Zhang, Cenwen Liu, Shunyi Huang, Yingzhao Jin, Yugeng Gao, Quan Cheng, Yunyun Mei   +8 more
wiley   +1 more source

Translatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes

Frontiers in Immunology, 2023
MAIT cells are multifunctional innate-like effector cells recognizing bacterial-derived vitamin B metabolites presented by the non-polymorphic MHC class I related protein 1 (MR1).
Josefine Jakob, Josefine Jakob, Josefine Jakob, Andrea Kröger, Andrea Kröger, Frank Klawonn, Dunja Bruder, Dunja Bruder, Lothar Jänsch   +8 more
doaj   +1 more source

Lipid and small-molecule display by CD1 and MR1 [PDF]

Nature Reviews Immunology, 2015
The antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells. The antigen display platforms in the four CD1 proteins are laterally asymmetrical, so that the T cell receptor (TCR)-binding surfaces are comprised of roofs and portals, rather than the long grooves seen in the MHC antigen ...
Van Rhijn, Ildiko, Godfrey, Dale I, Rossjohn, Jamie, Moody, D Branch   +3 more
openaire   +3 more sources

Unconventional functions of MR1 restricted T-cells

, 2023
The non-polymorphic MHC class I-related protein 1 (MR1) is an antigen presenting receptor that displays endogenous or microbial-derived metabolic intermediates.
Delowar Akther, Hossain
core   +1 more source