Results 41 to 50 of about 27,223 (192)

Control of the temporal development of Alzheimer’s disease pathology by the MR1/MAIT cell axis

Journal of Neuroinflammation, 2023
Background Neuroinflammation is an important feature of Alzheimer’s disease (AD). Understanding which aspects of the immune system are important in AD may lead to new therapeutic approaches.
Season K. Wyatt-Johnson, Holly N. Kersey, Juan F. Codocedo, Kathy L. Newell, Gary E. Landreth, Bruce T. Lamb, Adrian L. Oblak, Randy R. Brutkiewicz   +7 more
doaj   +1 more source

Diagnostic Criteria and Management of MELAS and Stroke-Like Episodes: Consensus-Based Statements. [PDF]

Eur J Neurol
International Delphi‐based consensus defining MELAS as a clinical syndrome characterized by one or more stroke‐like episodes in the presence of a pathogenic mitochondrial DNA variant, most commonly m.3243A>G. The panel provides practical recommendations for acute and chronic management of stroke‐like episodes and highlights the absence of proven ...
Mancuso M, Bellusci M, Carelli V, de Coo I, Diodato D, Distelmaier F, Hikmat O, Hirano M, Horvath R, Karaa A, Klopstock T, Koenig MK, Kornblum C, La Morgia C, Lopriore P, Martikainen MH, McFarland R, Musumeci O, Pitceathly RDS, Primiano G, Rahman S, Scaglia F, Schaefer A, Schiff M, Semmler L, Lamperti C, Servidei S.   +26 more
europepmc   +2 more sources

MR1-Restricted T Cells in Cancer Immunotherapy [PDF]

Cancers, 2020
Major histocompatibility complex class I-related (MR1) was first identified as a cell membrane protein involved in the development and expansion of a unique set of T cells expressing an invariant T-cell receptor (TCR) α-chain. These cells were initially discovered in mucosal tissues, such as the intestinal mucosa, so they are called mucosal-associated ...
Pedro Flores-Villanueva, Navid Sobhani, Xu Wang, Yong Li   +3 more
openaire   +2 more sources

Inverted Hierarchy Models of Neutrino Masses [PDF]

, 2000
We study models of neutrino masses which naturally give rise to an inverted mass hierarchy and bi-maximal mixing. The models are based on the see-saw mechanism with three right-handed neutrinos, which generates a single mass term of the form $\nu_e(\nu_{\
Altarelli, Altarelli, Altarelli, Altarelli, Altarelli, Apollonio, Bahcall, Balaji, Barbieri, Barbieri, Barbieri, Binetruy, Casas, Cervera, Chankowski, Dreiner, Ellis, Ellis, Elwood, Fritzsch, Fritzsch, Froggatt, Gell-Mann, Gell-Mann, Green, Gribov, Haba, Harvey, Ibanez, Irges, Joshipura, Kaus, King, King, King, King, Leontaris, Lola, Maki, Mikheyev, Mohapatra, Mohapatra, N. Nimai Singh, S.F. King, Shafi, Shafi, Wetterich, Wolfenstein, Wolfenstein, Yanagida   +49 more
core   +2 more sources

Effects of the Scale-dependent Vacuum Expectation Values in the Renormalization Group Analysis of Neutrino Masses [PDF]

, 2000
The contribution of scale-dependent vacuum expectation values (VEVs) of Higgs scalars, which gives significant effects in the evolution of fundamental fermion masses in the Minimal Supersymmetric Standard Model (MSSM), is now considered in the derivation
Singh, N. Nimai
core   +2 more sources

Functionally diverse human T cells recognize non-microbial antigens presented by MR1

eLife, 2017
MHC class I-related molecule MR1 presents riboflavin- and folate-related metabolites to mucosal-associated invariant T cells, but it is unknown whether MR1 can present alternative antigens to other T cell lineages.
Marco Lepore, Artem Kalinichenko, Salvatore Calogero, Pavanish Kumar, Bhairav Paleja, Mathias Schmaler, Vipin Narang, Francesca Zolezzi, Michael Poidinger, Lucia Mori, Gennaro De Libero   +10 more
doaj   +1 more source

KMS conditions for 4-point Green functions at finite temperature [PDF]

, 2000
We study the 4-point function in the Keldysh formalism of the closed time path formulation of real time finite temperature field theory. We derive the KMS conditions for these functions and discuss the number of 4-point functions that are independent ...
Hou Defu, J. C. Sowiak, J. I. Kapusta, K.-C. Chou, L. V. Keldysh, M. E. Carrington, M. E. Carrington, M. E. Carrington, M. E. Carrington, M. LeBellac, N. P. Landsman, P. A. Henning, P. Aurenche, P. C. Martin, R. Kubo, R. Kubo   +15 more
core   +2 more sources

Linear Koszul Duality II - Coherent sheaves on perfect sheaves [PDF]

, 2015
In this paper we continue the study (initiated in a previous article) of linear Koszul duality, a geometric version of the standard duality between modules over symmetric and exterior algebras.
Bezrukavnikov, Ciocan-Fontanine, Goresky, I. Mirković, Laumon, Mirković, S. Riche, Spaltenstein   +7 more
core   +2 more sources

CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells

Journal of Experimental Medicine, 2022
Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I)–related protein 1 (MR1). Most MAIT cells in human peripheral blood express CD8αα or CD8αβ coreceptors, and the binding site for CD8 on MHC-I molecules is relatively ...
Michael N.T. Souter, Wael Awad, Shihan Li, Troi J. Pediongco, Bronwyn S. Meehan, Lucy J. Meehan, Zehua Tian, Zhe Zhao, Huimeng Wang, Adam Nelson, Jérôme Le Nours, Yogesh Khandokar, T. Praveena, Jacinta Wubben, Jie Lin, Lucy C. Sullivan, George O. Lovrecz, Jeffrey Y.W. Mak, Ligong Liu, Lyudmila Kostenko, Katherine Kedzierska, Alexandra J. Corbett, David P. Fairlie, Andrew G. Brooks, Nicholas A. Gherardin, Adam P. Uldrich, Zhenjun Chen, Jamie Rossjohn, Dale I. Godfrey, James McCluskey, Daniel G. Pellicci, Sidonia B.G. Eckle   +31 more
openaire   +3 more sources

Characterization of Tumor-Infiltrating Lymphocyte-Derived Atypical TCRs Recognizing Breast Cancer in an MR1-Dependent Manner

Cells
The MHC class I-related 1 (MR1) molecule is a non-polymorphic antigen-presenting molecule that presents several metabolites to MR1-restricted T cells, including mucosal-associated invariant T (MAIT) cells.
Abdul Hayee, Eiji Kobayashi, Chihiro Motozono, Hiroshi Hamana, Ha Thi Viet My, Takuya Okada, Naoki Toyooka, Satoshi Yamaguchi, Tatsuhiko Ozawa, Hiroyuki Kishi   +9 more
doaj   +1 more source