Results 41 to 50 of about 6,919 (168)

Lipid and small-molecule display by CD1 and MR1 [PDF]

Nature Reviews Immunology, 2015
The antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells. The antigen display platforms in the four CD1 proteins are laterally asymmetrical, so that the T cell receptor (TCR)-binding surfaces are comprised of roofs and portals, rather than the long grooves seen in the MHC antigen ...
Van Rhijn, Ildiko, Godfrey, Dale I, Rossjohn, Jamie, Moody, D Branch   +3 more
openaire   +3 more sources

Knowledge gaps and research directions in migration ecology for advancing the conservation of migratory songbirds

Biological Reviews, EarlyView.
ABSTRACT Understanding migration ecology is essential for effective conservation of migratory species. To achieve a comprehensive understanding of the ecology of migrating species, it is necessary to study how species react to the complex interplay of intrinsic and extrinsic conditions when optimizing their migratory journey in terms of survival ...
Daniel A. F. Bloche, Heiko Schmaljohann, Nir Sapir   +2 more
wiley   +1 more source

MR1-ligand cross-linking identifies vitamin B6 metabolites as TCR-reactive antigens

Cell Reports: Methods
Summary: Major histocompatibility complex class I-related protein 1 (MR1) plays a central role in the immune recognition of infected cells and can mediate T cell detection of cancer. Knowledge of the nature of the ligands presented by MR1 is still sparse
Thierry Schmidlin, Enas Behiry, Hannah Thomas, Garry Dolton, Fabio Marino, Samiul Hasan, Magdalena von Essen, Rose M. Gathungu, Barbara A. Steigenberger, Hayden Selvadurai, Joseph Dukes, Paul E. Brennan, Owen B. Spiller, Jonathan D. Silk, Andrew K. Sewell, Nicola Ternette   +15 more
doaj   +1 more source

A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells

Chemistry – A European Journal, EarlyView.
A microbial metabolite covalently binds immunological protein MR1 to potently activate specific lymphocytes called MAIT cells, but it is too unstable for biological applications. Here, using synthesis, assays, protein crystallography, and computer modelling, we report a water‐stable analogue that activates reporter cells expressing the MAIT T cell ...
Jeffrey Y. W. Mak, Huy N. Hoang, Wael Awad, Xin Yi Lim, Damica D. Laurie, Ryan J. D. Rivero, James McCluskey, Alexandra J. Corbett, Jamie Rossjohn, David P. Fairlie   +9 more
wiley   +1 more source

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +2 more sources

A Co‐Designed Implicit‐Reset Path PFD and Current Mismatch Compensated CP Enabling Sub‐0.5% Mismatch and Dead Zone‐Free for Low‐Spur PLLs

International Journal of Circuit Theory and Applications, EarlyView.
A co‐designed implicit‐reset phase‐frequency detector (PFD) and nonlinear amplifier‐assisted charge pump (CP) achieve dead zone‐free operation from 10 MHz to 4.7 GHz with < 0.5% current mismatch without calibration, enabling −80 dBc of reference spur and 0.50 ps of RMS jitter in a 180 nm of CMOS PLL.
A. Ghaemnia, Jincheng Yang, Xiaojiong Fei, G. Zhang   +3 more
wiley   +1 more source

Phenotype‐guided etiologic workup in a prospective cohort of 144 adults with developmental and epileptic encephalopathy

Epilepsia Open, EarlyView.
Abstract Objectives Adults with developmental and epileptic encephalopathies (DEEs) often enter adult neurology care without etiologic clarification because of incomplete transition from pediatric services, outdated investigations, and attenuation of childhood electro‐clinical features over time.
Giuseppe d’Orsi, Umberto Costantino, Maria Teresa Di Claudio, Carmela Pia Ferro, Pietro Palumbo, Mario Benvenuto, Massimiliano Copetti, Leonardo D'Agruma, Massimo Carella, Marco Castori, Orazio Palumbo   +10 more
wiley   +1 more source

De Novo Discovery of Nonstandard Thioisoindole‐Bridged Bicyclic Peptides Targeting Traf2‐ and NCK‐Interacting Kinase

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang, Alexander A. Vinogradov, Keisuke Hamada, Yin Sun, Toru Sengoku, Hiroaki Suga   +5 more
wiley   +2 more sources

Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection

iScience
Summary: The major histocompatibility complex (MHC), Class-I-related (MR1) molecule presents microbiome-synthesized metabolites to Mucosal-associated invariant T (MAIT) cells, present at sites of herpes simplex virus (HSV) infection.
Carolyn Samer, Hamish E.G. McWilliam, Brian P. McSharry, Thilaga Velusamy, James G. Burchfield, Richard J. Stanton, David C. Tscharke, Jamie Rossjohn, Jose A. Villadangos, Allison Abendroth, Barry Slobedman   +10 more
doaj   +1 more source

Translatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes

Frontiers in Immunology, 2023
MAIT cells are multifunctional innate-like effector cells recognizing bacterial-derived vitamin B metabolites presented by the non-polymorphic MHC class I related protein 1 (MR1).
Josefine Jakob, Josefine Jakob, Josefine Jakob, Andrea Kröger, Andrea Kröger, Frank Klawonn, Dunja Bruder, Dunja Bruder, Lothar Jänsch   +8 more
doaj   +1 more source