Results 51 to 60 of about 8,186 (190)
Remote Sensing in Ecology and Conservation, EarlyView.Vertical‐looking radar provides a first multi‐year analysis of migratory bat phenology in Europe. Bat activity was lowest in winter, increased from spring, and peaked in summer, with similar timing of pre‐ and post‐maternity migrations across years.
Silvia Giuntini +5 more
wiley +1 more source
Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU). [PDF]
PLoS ONE, 2018 Mucosal-associated invariant T (MAIT) cells are an abundant class of innate T cells restricted by the MHC I-related molecule MR1. MAIT cells can recognize bacterially-derived metabolic intermediates from the riboflavin pathway presented by MR1 and are ...
Kelin Li +8 more
doaj +1 more source
Characterisation of mucosal associated invariant T-cells and MR1 in ruminants [PDF]
, 2010 Mucosal associated invariant T-cells (MAIT) are a phylogenetically conserved subset of alpha/beta T-cells with natural killer-like (NK) activity. MAIT are defined by the expression of an invariant T-cell receptor alpha (TCRα) chain; in mice and humans ...
Goldfinch, Nicholas Graham
core
Multi‐Strategy Synergy‐Based Differential Evolution for Large Wind Farm Layout Optimization
CAAI Transactions on Intelligence Technology, EarlyView.ABSTRACT Exploring clean energy alternatives to fossil fuels has become a major research focus worldwide. Wind energy is regarded as one of the most promising renewable energy sources due to its clean and sustainable nature. However, wake interactions among turbines significantly reduce power conversion efficiency, making wind farm layout optimization (
Haotian Li +5 more
wiley +1 more source
, 2016 Our data support the hypothesis that the primary MR1 presentation pathway for exogenous ligands like 6-FP is through the ER. MR1 loading of exogenous ligand through this pathway requires the ER-localized SNARE protein, Stx18, but not the TGN-endosome ...
David M. Lewinsohn (266240) +7 more
core +1 more source
MAIT Cells Suppress IgE‐Mediated Asthma via IFNγ‐Dependent B Cell Regulation
Allergy, EarlyView.In this study, we demonstrate that MAIT cell antagonism during sensitization and challenge with HDM worsens the development of airway hyperreactivity without effects on type 2 or 17 associated cytokine production or lung inflammation. Rather, MAIT cells appear to regulate HDM‐induced asthma through direct inhibition of IgE production.
Angela M. Cannata +6 more
wiley +1 more source
Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection
iScienceSummary: The major histocompatibility complex (MHC), Class-I-related (MR1) molecule presents microbiome-synthesized metabolites to Mucosal-associated invariant T (MAIT) cells, present at sites of herpes simplex virus (HSV) infection.
Carolyn Samer +10 more
doaj +1 more source
MR1-restricted pan-cancer T cells [PDF]
Nature Reviews Immunology, 2020 Researchers identify a new population of cytotoxic T cells that recognize the non-polymorphic MHC class I-related molecule MR1 on multiple different cancer cells, raising the prospect of its use as T cell-based therapy for multiple cancers.
openaire +2 more sources
Differential antigenic requirements by diverse MR1-restricted T cells
, 2022 MHC-related protein 1 (MR1) presents microbial riboflavin metabolites to mucosal-associated invariant T (MAIT) cells for surveillance of microbial presence. MAIT cells express a semi-invariant T-cell receptor (TCR), which recognizes MR1-antigen complexes
Redmond, SJ +7 more
core +1 more source
British Journal of Educational Technology, EarlyView.Abstract Generative AI is increasingly positioned as a peer in collaborative learning, yet its effects on ethical deliberation remain unclear. We report a between‐subjects experiment with university students (N = 217) who discussed an autonomous‐vehicle dilemma in triads under three conditions: human‐only control, supportive AI teammate or contrarian ...
Yueqiao Jin +7 more
wiley +1 more source