Results 1 to 10 of about 4,910,474 (212)

Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responses. [PDF]

PLoS Pathogens
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that respond to riboflavin biosynthesis and cytokines through TCR-dependent and -independent pathways, respectively.
Shivam K Purohit, Lauren Stern, Alexandra J Corbett, Jeffrey Y W Mak, David P Fairlie, Barry Slobedman, Allison Abendroth   +6 more
doaj   +4 more sources

MAITabolism2 – the emerging understanding of MAIT cell metabolism and their role in metabolic disease [PDF]

Frontiers in Immunology, 2023
Mucosal associated invariant T (MAIT) cells are a population of unconventional innate T cells due to their non-MHC restriction and rapid effector responses.
Nidhi Kedia-Mehta, Nidhi Kedia-Mehta, Andrew E. Hogan, Andrew E. Hogan, Andrew E. Hogan   +4 more
doaj   +2 more sources

Disruption of riboflavin biosynthesis in mycobacteria establishes riboflavin pathway intermediates as key precursors of MAIT cell agonists. [PDF]

PLoS Pathogens
Mucosal-associated invariant T (MAIT) cells exhibit an intrinsic ability to recognize and respond to microbial infections. The semi-invariant antigen recognition receptor of MAIT cells specifically detects the non-polymorphic antigen-presenting molecule,
Melissa D Chengalroyen, Nurudeen Oketade, Aneta Worley, Megan Lucas, Luisa Maria Nieto Ramirez, Mabule L Raphela, Gwendolyn M Swarbrick, Paul S Soma, Mandisa Zuma, Digby F Warner, Deborah A Lewinsohn, Carolina Mehaffy, Erin J Adams, William Hildebrand, Karen M Dobos, Valerie Mizrahi, David M Lewinsohn   +16 more
doaj   +2 more sources

Distinct MAIT cell phenotypes associated with sepsis clinical outcome in emergency department patients [PDF]

Clinical & Translational Immunology
Objectives Rapid diagnosis and intervention are critical for sepsis patient outcomes. However, diagnosis is challenging because of a heterogenic patient group as well as sometimes vague symptoms when the patient presents at the emergency department ...
Johanna Emgård, Iva Filipovic, Christian Unge, Laura M Palma Medina, Åsa Parke, Helena Bergsten, Kirsten Moll, Majda Dzidic, Helena Alpkvist, Hong Fang, Volkan Özenci, Niklas K Björkström, Mattias Svensson, Johan K Sandberg, Kristoffer Strålin, Anna Norrby‐Teglund   +15 more
doaj   +2 more sources

Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin. [PDF]

Cell, 2023
Ruf B, Bruhns M, Babaei S, Kedei N, Ma L, Revsine M, Benmebarek MR, Ma C, Heinrich B, Subramanyam V, Qi J, Wabitsch S, Green BL, Bauer KC, Myojin Y, Greten LT, McCallen JD, Huang P, Trehan R, Wang X, Nur A, Murphy Soika DQ, Pouzolles M, Evans CN, Chari R, Kleiner DE, Telford W, Dadkhah K, Ruchinskas A, Stovroff MK, Kang J, Oza K, Ruchirawat M, Kroemer A, Wang XW, Claassen M, Korangy F, Greten TF.   +37 more
europepmc   +2 more sources

IL7RA single nucleotide polymorphisms are associated with the size and function of the MAIT cell population in treated HIV-1 infection

Frontiers in Immunology, 2022
MAIT cells are persistently depleted and functionally exhausted in HIV-1-infected patients despite long-term combination antiretroviral therapy (cART). IL-7 treatment supports MAIT cell reconstitution in vivo HIV-1-infected individuals and rescues their ...
Fei Han, Fei Han, Muhammad Yaaseen Gulam, Yichao Zheng, Yichao Zheng, Nurul Syuhada Zulhaimi, Nurul Syuhada Zulhaimi, Wan Rong Sia, Dan He, Dan He, Amanda Ho, Amanda Ho, Leila Hadadi, Zhenyu Liu, Zhenyu Liu, Peiwu Qin, Peiwu Qin, Peter E. Lobie, Peter E. Lobie, Adeeba Kamarulzaman, Adeeba Kamarulzaman, Lin-Fa Wang, Johan K. Sandberg, Sharon R. Lewin, Reena Rajasuriar, Reena Rajasuriar, Reena Rajasuriar, Edwin Leeansyah, Edwin Leeansyah, Edwin Leeansyah, Edwin Leeansyah   +30 more
doaj   +1 more source

Augmentation of the Riboflavin-Biosynthetic Pathway Enhances Mucosa-Associated Invariant T (MAIT) Cell Activation and Diminishes Mycobacterium tuberculosis Virulence

mBio, 2022
Mucosa-associated invariant T (MAIT) cells play a critical role in antimicrobial defense. Despite increased understanding of their mycobacterial ligands and the clinical association of MAIT cells with tuberculosis (TB), their function in protection ...
Ruchi Jain Dey, Bappaditya Dey, Melanie Harriff, Elizabeth T. Canfield, David M. Lewinsohn, William R. Bishai   +5 more
doaj   +1 more source

Frequencies of CD8 and DN MAIT Cells Among Children Diagnosed With Type 1 Diabetes Are Similar to Age-Matched Controls

Frontiers in Immunology, 2021
Mucosal-associated invariant T (MAIT) cells have been implicated in various forms of autoimmunity, including type 1 diabetes (T1D). Here, we tested the hypothesis that CD8 and double negative (DN) MAIT cell frequencies were altered among diagnosed T1D ...
Robert Z. Harms, Katie R. Ostlund, Monina Cabrera, Monina Cabrera, Earline Edwards, Earline Edwards, Victoria B. Smith, Lynette M. Smith, Nora Sarvetnick, Nora Sarvetnick   +9 more
doaj   +1 more source

Comparative transcriptomes reveal pro-survival and cytotoxic programs of mucosal-associated invariant T cells upon Bacillus Calmette–Guérin stimulation

Frontiers in Cellular and Infection Microbiology, 2023
Mucosal-associated invariant T (MAIT) cells are protective against tuberculous and non-tuberculous mycobacterial infections with poorly understood mechanisms. Despite an innate-like nature, MAIT cell responses remain heterogeneous in bacterial infections.
Manju Sharma, Liang Niu, Xiang Zhang, Shouxiong Huang   +3 more
doaj   +1 more source

MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection

Frontiers in Immunology, 2021
Mucosal associated invariant T (MAIT) cells are a class of innate-like T cells that utilize a semi-invariant αβ T cell receptor to recognize small molecule ligands produced by bacteria and fungi.
Sharon Khuzwayo, Sharon Khuzwayo, Maphe Mthembu, Maphe Mthembu, Erin W. Meermeier, Sanjay M. Prakadan, Sanjay M. Prakadan, Sanjay M. Prakadan, Samuel W. Kazer, Samuel W. Kazer, Samuel W. Kazer, Thierry Bassett, Kennedy Nyamande, Dilshaad Fakey Khan, Priya Maharaj, Mohammed Mitha, Moosa Suleman, Moosa Suleman, Zoey Mhlane, Dirhona Ramjit, Farina Karim, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, David M. Lewinsohn, David M. Lewinsohn, David M. Lewinsohn, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Emily B. Wong, Emily B. Wong, Emily B. Wong, Emily B. Wong   +36 more
doaj   +1 more source