Results 1 to 10 of about 12,025,155 (147)

Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin. [PDF]

Cell, 2023
SUMMARY Mucosal-associated invariant T (MAIT) cells represent an abundant innate-like T cell subtype in the human liver. MAITs are assigned crucial roles in regulating immunity and inflammation, yet their role in liver cancer remains elusive.
Ruf B, Bruhns M, Babaei S, Kedei N, Ma L, Revsine M, Benmebarek MR, Ma C, Heinrich B, Subramanyam V, Qi J, Wabitsch S, Green BL, Bauer KC, Myojin Y, Greten LT, McCallen JD, Huang P, Trehan R, Wang X, Nur A, Murphy Soika DQ, Pouzolles M, Evans CN, Chari R, Kleiner DE, Telford W, Dadkhah K, Ruchinskas A, Stovroff MK, Kang J, Oza K, Ruchirawat M, Kroemer A, Wang XW, Claassen M, Korangy F, Greten TF.   +37 more
europepmc   +3 more sources

Disruption of riboflavin biosynthesis in mycobacteria establishes riboflavin pathway intermediates as key precursors of MAIT cell agonists. [PDF]

PLoS Pathogens
Mucosal-associated invariant T (MAIT) cells exhibit an intrinsic ability to recognize and respond to microbial infections. The semi-invariant antigen recognition receptor of MAIT cells specifically detects the non-polymorphic antigen-presenting molecule,
Melissa D Chengalroyen, Nurudeen Oketade, Aneta Worley, Megan Lucas, Luisa Maria Nieto Ramirez, Mabule L Raphela, Gwendolyn M Swarbrick, Paul S Soma, Mandisa Zuma, Digby F Warner, Deborah A Lewinsohn, Carolina Mehaffy, Erin J Adams, William Hildebrand, Karen M Dobos, Valerie Mizrahi, David M Lewinsohn   +16 more
doaj   +3 more sources

MAITabolism2 – the emerging understanding of MAIT cell metabolism and their role in metabolic disease [PDF]

Frontiers in Immunology, 2023
Mucosal associated invariant T (MAIT) cells are a population of unconventional innate T cells due to their non-MHC restriction and rapid effector responses.
Nidhi Kedia-Mehta, Nidhi Kedia-Mehta, Andrew E. Hogan, Andrew E. Hogan, Andrew E. Hogan   +4 more
doaj   +3 more sources

Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responses. [PDF]

PLoS Pathogens
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that respond to riboflavin biosynthesis and cytokines through TCR-dependent and -independent pathways, respectively.
Shivam K Purohit, Lauren Stern, Alexandra J Corbett, Jeffrey Y W Mak, David P Fairlie, Barry Slobedman, Allison Abendroth   +6 more
doaj   +3 more sources

Signals that control MAIT cell function in healthy and inflamed human tissues. [PDF]

Immunol Rev
Mucosal‐associated invariant T (MAIT) cells have a semi‐invariant T‐cell receptor that allows recognition of antigen in the context of the MHC class I‐related (MR1) protein. Metabolic intermediates of the riboflavin synthesis pathway have been identified
Konecny AJ, Huang Y, Setty M, Prlic M.
europepmc   +3 more sources

MAIT cell homing in intestinal homeostasis and inflammation. [PDF]

Sci Adv
Mucosa-associated invariant T (MAIT) cells are a large population of unconventional T cells widely distributed in the human gastrointestinal tract. Their homing to the gut is central to maintaining mucosal homeostasis and immunity.
Wu Z, Chen X, Han F, Leeansyah E.
europepmc   +2 more sources

Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity. [PDF]

Nat Immunol, 2023
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial metabolites through a semi-invariant T cell receptor (TCR). Major questions remain regarding the extent of human MAIT cell functional and clonal diversity.
Garner LC, Amini A, FitzPatrick MEB, Lett MJ, Hess GF, Filipowicz Sinnreich M, Provine NM, Klenerman P.   +7 more
europepmc   +2 more sources

Transcriptomes and metabolism define mouse and human MAIT cell populations. [PDF]

Sci Immunol, 2023
Mucosal-associated invariant T (MAIT) cells are a subset of T lymphocytes that respond to microbial metabolites. We defined MAIT cell populations in different organs and characterized the developmental pathway of mouse and human MAIT cells in the thymus ...
Chandra S, Ascui G, Riffelmacher T, Chawla A, Ramírez-Suástegui C, Castelan VC, Seumois G, Simon H, Murray MP, Seo GY, Premlal ALR, Schmiedel B, Verstichel G, Li Y, Lin CH, Greenbaum J, Lamberti J, Murthy R, Nigro J, Cheroutre H, Ottensmeier CH, Hedrick SM, Lu LF, Vijayanand P, Kronenberg M.   +24 more
europepmc   +2 more sources

MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming. [PDF]

Nat Commun, 2023
Recent data have shown that liver fibrosis can regress even at later stages of cirrhosis and shifting the immune response from pro-inflammatory towards a resolutive profile is considered as a promising option.
Mabire M, Hegde P, Hammoutene A, Wan J, Caër C, Sayegh RA, Cadoux M, Allaire M, Weiss E, Thibault-Sogorb T, Lantz O, Goodhardt M, Paradis V, de la Grange P, Gilgenkrantz H, Lotersztajn S.   +15 more
europepmc   +2 more sources

Targeting the MR1-MAIT cell axis improves vaccine efficacy and affords protection against viral pathogens. [PDF]

PLoS Pathog, 2023
Mucosa-associated invariant T (MAIT) cells are MR1-restricted, innate-like T lymphocytes with tremendous antibacterial and immunomodulatory functions. MAIT cells also sense and respond to viral infections in an MR1-independent fashion.
Rashu R, Ninkov M, Wardell CM, Benoit JM, Wang NI, Meilleur CE, D'Agostino MR, Zhang A, Feng E, Saeedian N, Bell GI, Vahedi F, Hess DA, Barr SD, Troyer RM, Kang CY, Ashkar AA, Miller MS, Haeryfar SMM.   +18 more
europepmc   +3 more sources