Results 1 to 10 of about 13,292 (150)

IL7RA single nucleotide polymorphisms are associated with the size and function of the MAIT cell population in treated HIV-1 infection [PDF]

Frontiers in Immunology, 2022
MAIT cells are persistently depleted and functionally exhausted in HIV-1-infected patients despite long-term combination antiretroviral therapy (cART). IL-7 treatment supports MAIT cell reconstitution in vivo HIV-1-infected individuals and rescues their ...
Fei Han, Fei Han, Muhammad Yaaseen Gulam, Yichao Zheng, Yichao Zheng, Nurul Syuhada Zulhaimi, Nurul Syuhada Zulhaimi, Wan Rong Sia, Dan He, Dan He, Amanda Ho, Amanda Ho, Leila Hadadi, Zhenyu Liu, Zhenyu Liu, Peiwu Qin, Peiwu Qin, Peter E. Lobie, Peter E. Lobie, Adeeba Kamarulzaman, Adeeba Kamarulzaman, Lin-Fa Wang, Johan K. Sandberg, Sharon R. Lewin, Reena Rajasuriar, Reena Rajasuriar, Reena Rajasuriar, Edwin Leeansyah, Edwin Leeansyah, Edwin Leeansyah, Edwin Leeansyah   +30 more
doaj   +2 more sources

MAITabolism2 – the emerging understanding of MAIT cell metabolism and their role in metabolic disease [PDF]

Frontiers in Immunology, 2023
Mucosal associated invariant T (MAIT) cells are a population of unconventional innate T cells due to their non-MHC restriction and rapid effector responses.
Nidhi Kedia-Mehta, Nidhi Kedia-Mehta, Andrew E. Hogan, Andrew E. Hogan, Andrew E. Hogan   +4 more
doaj   +2 more sources

Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19

Frontiers in Immunology, 2021
BackgroundMucosal-associated invariant T (MAIT) cells are considered to participate of the host immune response against acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, single-cell transcriptomic profiling of MAIT ...
Jijing Shi, Jijing Shi, Jianglin Zhou, Xiaochang Zhang, Wei Hu, Wei Hu, Jin-Fang Zhao, Shengqi Wang, Fu-Sheng Wang, Fu-Sheng Wang, Ji-Yuan Zhang   +10 more
doaj   +3 more sources

CXCL16 Stimulates Antigen-Induced MAIT Cell Accumulation but Trafficking During Lung Infection Is CXCR6-Independent

Frontiers in Immunology, 2020
Mucosa-associated invariant T (MAIT) cells are a unique T cell subset that contributes to protective immunity against microbial pathogens, but little is known about the role of chemokines in recruiting MAIT cells to the site of infection.
Huifeng Yu, Amy Yang, Ligong Liu, Ligong Liu, Jeffrey Y. W. Mak, Jeffrey Y. W. Mak, David P. Fairlie, David P. Fairlie, Siobhan Cowley   +8 more
doaj   +3 more sources

MicroRNA-155 Regulates MAIT1 and MAIT17 Cell Differentiation

Frontiers in Cell and Developmental Biology, 2021
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that develop in the thymus through three maturation stages to acquire effector function and differentiate into MAIT1 (T-bet+) and MAIT17 (RORγt+) subsets.
Tingting Liu, Tingting Liu, Tingting Liu, Jie Wang, Jie Wang, Kalpana Subedi, Kalpana Subedi, Qijun Yi, Qijun Yi, Li Zhou, Li Zhou, Qing-Sheng Mi, Qing-Sheng Mi   +12 more
doaj   +3 more sources

Mucosal Associated Invariant T cells in the human gastric mucosa and blood: Role in Helicobacter pylori infection [PDF]

Frontiers in Immunology, 2015
Mucosal-associated invariant T (MAIT) cells represent a class of antimicrobial innate-like T cells that have been characterized in human blood, liver, lungs and intestine.
Jayaum S Booth, Jayaum S Booth, Rosangela eSalerno-Goncalves, Rosangela eSalerno-Goncalves, Thomas G Blanchard, Seema A. Patil, Seema A. Patil, Howard A. Kader, Anca M. Safta, Lindsay M. Morningstar, Steven J. Czinn, Bruce D. Greenwald, Bruce D. Greenwald, Marcelo B. Sztein, Marcelo B. Sztein, Marcelo B. Sztein   +15 more
doaj   +2 more sources

Disruption of riboflavin biosynthesis in mycobacteria establishes riboflavin pathway intermediates as key precursors of MAIT cell agonists. [PDF]

PLoS Pathogens
Mucosal-associated invariant T (MAIT) cells exhibit an intrinsic ability to recognize and respond to microbial infections. The semi-invariant antigen recognition receptor of MAIT cells specifically detects the non-polymorphic antigen-presenting molecule,
Melissa D Chengalroyen, Nurudeen Oketade, Aneta Worley, Megan Lucas, Luisa Maria Nieto Ramirez, Mabule L Raphela, Gwendolyn M Swarbrick, Paul S Soma, Mandisa Zuma, Digby F Warner, Deborah A Lewinsohn, Carolina Mehaffy, Erin J Adams, William Hildebrand, Karen M Dobos, Valerie Mizrahi, David M Lewinsohn   +16 more
doaj   +2 more sources

Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responses. [PDF]

PLoS Pathogens
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that respond to riboflavin biosynthesis and cytokines through TCR-dependent and -independent pathways, respectively.
Shivam K Purohit, Lauren Stern, Alexandra J Corbett, Jeffrey Y W Mak, David P Fairlie, Barry Slobedman, Allison Abendroth   +6 more
doaj   +2 more sources

Distinct MAIT cell phenotypes associated with sepsis clinical outcome in emergency department patients [PDF]

Clinical & Translational Immunology
Objectives Rapid diagnosis and intervention are critical for sepsis patient outcomes. However, diagnosis is challenging because of a heterogenic patient group as well as sometimes vague symptoms when the patient presents at the emergency department ...
Johanna Emgård, Iva Filipovic, Christian Unge, Laura M Palma Medina, Åsa Parke, Helena Bergsten, Kirsten Moll, Majda Dzidic, Helena Alpkvist, Hong Fang, Volkan Özenci, Niklas K Björkström, Mattias Svensson, Johan K Sandberg, Kristoffer Strålin, Anna Norrby‐Teglund   +15 more
doaj   +2 more sources

Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin. [PDF]

Cell, 2023
Ruf B, Bruhns M, Babaei S, Kedei N, Ma L, Revsine M, Benmebarek MR, Ma C, Heinrich B, Subramanyam V, Qi J, Wabitsch S, Green BL, Bauer KC, Myojin Y, Greten LT, McCallen JD, Huang P, Trehan R, Wang X, Nur A, Murphy Soika DQ, Pouzolles M, Evans CN, Chari R, Kleiner DE, Telford W, Dadkhah K, Ruchinskas A, Stovroff MK, Kang J, Oza K, Ruchirawat M, Kroemer A, Wang XW, Claassen M, Korangy F, Greten TF.   +37 more
europepmc   +2 more sources