Mucosal Associated Invariant T cells in the human gastric mucosa and blood: Role in Helicobacter pylori infection [PDF]
Frontiers in Immunology, 2015 Mucosal-associated invariant T (MAIT) cells represent a class of antimicrobial innate-like T cells that have been characterized in human blood, liver, lungs and intestine.
Jayaum S Booth +15 more
doaj +2 more sources
Frequencies of Circulating MAIT Cells Are Diminished in Chronic HCV, HIV and HCV/HIV Co-Infection and Do Not Recover during Therapy. [PDF]
PLoS ONE, 2016 Mucosal-associated invariant T (MAIT) cells comprise a subpopulation of T cells that can be activated by bacterial products and cytokines to produce IFN-γ. Since little is known on MAIT cells during HCV infection, we compared their phenotype and function
Michelle Spaan +10 more
doaj +4 more sources
Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells [PDF]
Nature Communications, 2017 MAIT cells are activated by MR1 restricted antigens derived from riboflavin biosynthesis. Here the authors characterize MAIT cell antigenicity and synthesize a water stable antigen that activates human MAIT cellsin vitro and mouse MAIT cells in vivo.
Jeffrey Y. W. Mak +10 more
doaj +5 more sources
Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal-Associated Invariant T (MAIT) Cell Function. [PDF]
ImmunologyIntegrated transcriptomic, proteomic and flow cytometry analyses reveal that STAT1 negatively regulates MAIT cell effector and glycolytic functions, while STAT3, STAT5 and HIF1α act as positive modulators. Targeting these pathways may offer new strategies to restore MAIT cell function in immune dysregulation and cancer.
Cheng OJ +7 more
europepmc +2 more sources
Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19
Frontiers in Immunology, 2021 BackgroundMucosal-associated invariant T (MAIT) cells are considered to participate of the host immune response against acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, single-cell transcriptomic profiling of MAIT ...
Wang Fusheng, Ji-Yuan Zhang
exaly +3 more sources
Frontiers in Immunology, 2020 Mucosa-associated invariant T (MAIT) cells are a unique T cell subset that contributes to protective immunity against microbial pathogens, but little is known about the role of chemokines in recruiting MAIT cells to the site of infection.
Ligong Liu +2 more
exaly +3 more sources
Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy [PDF]
MedComm (2020)Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
He W, McMichael A.
europepmc +2 more sources
Frontiers in Immunology, 2021 Mucosal associated invariant T (MAIT) cells are a class of innate-like T cells that utilize a semi-invariant αβ T cell receptor to recognize small molecule ligands produced by bacteria and fungi.
Sharon Khuzwayo +36 more
doaj +1 more source
Low mucosal-associated invariant T-cell number in peripheral blood of patients with immune thrombocytopenia and their response to prednisolone. [PDF]
PLoS ONE, 2018 Mucosal-associated invariant T (MAIT) cells help protect against certain infections and are related to some autoimmune diseases. Immune thrombocytopenia (ITP) is a relatively rare hematological autoimmune disease associated with low platelet count.
Takaaki Maekawa +11 more
doaj +1 more source
mBio, 2022 Mucosa-associated invariant T (MAIT) cells play a critical role in antimicrobial defense. Despite increased understanding of their mycobacterial ligands and the clinical association of MAIT cells with tuberculosis (TB), their function in protection ...
Ruchi Jain Dey +5 more
doaj +1 more source