Results 21 to 30 of about 10,390 (221)

Effects of interleukin-23 on the activation of mucosal-associated invariant T cells from oral lichen planus

Journal of International Medical Research, 2023
Objective Oral lichen planus (OLP) is a T cell-mediated inflammatory condition in the oral cavity. Mucosal-associated invariant T (MAIT) cells are gaining more relevance in immune diseases because they can be activated by cytokines without T cell ...
Fang Wang, Xiu-Li Zhang, Jing-Ya Yang, Gang Zhou   +3 more
doaj   +1 more source

Varicella Zoster Virus infects mucosal associated Invariant T cells

Frontiers in Immunology, 2023
IntroductionMucosal Associated Invariant T (MAIT) cells are innate-like T cells that respond to conserved pathogen-derived vitamin B metabolites presented by the MHC class I related-1 molecule (MR1) antigen presentation pathway.
Shivam K. Purohit, Alexandra J. Corbett, Barry Slobedman, Allison Abendroth   +3 more
doaj   +1 more source

Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections

Frontiers in Immunology, 2021
Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells that utilize a semi-invariant T cell receptor (TCR) α chain and are restricted by the highly conserved antigen presenting molecule MR1.
Matthew D. Edmans, Matthew D. Edmans, Timothy K. Connelley, Siddharth Jayaraman, Christina Vrettou, Martin Vordermeier, Martin Vordermeier, Jeffrey Y. W. Mak, Jeffrey Y. W. Mak, Ligong Liu, Ligong Liu, Ligong Liu, David P. Fairlie, David P. Fairlie, David P. Fairlie, Emmanuel Atangana Maze, Tiphany Chrun, Paul Klenerman, Sidonia B. G. Eckle, Elma Tchilian, Lindert Benedictus, Lindert Benedictus   +21 more
doaj   +1 more source

In patients with primary Sjögren’s syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells

Frontiers in Immunology, 2022
IntroductionMucosal-associated invariant T (MAIT) cells might play a role in B cell hyperactivity and local inflammation in primary Sjögren’s syndrome (pSS), just like previously studied mucosa-associated CCR9+ and CXCR5+ T helper cells.
Anneline C. Hinrichs, Anneline C. Hinrichs, Aike A. Kruize, Helen L. Leavis, Joel A. G. van Roon, Joel A. G. van Roon   +5 more
doaj   +1 more source

Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19

Frontiers in Immunology, 2021
BackgroundMucosal-associated invariant T (MAIT) cells are considered to participate of the host immune response against acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, single-cell transcriptomic profiling of MAIT ...
Jijing Shi, Jijing Shi, Jianglin Zhou, Xiaochang Zhang, Wei Hu, Wei Hu, Jin-Fang Zhao, Shengqi Wang, Fu-Sheng Wang, Fu-Sheng Wang, Ji-Yuan Zhang   +10 more
doaj   +1 more source

Check MAIT [PDF]

The Journal of Immunology, 2014
Abstract The evolutionary conservation of T lymphocyte subsets bearing αβ TCRs using invariant α-chains is indicative of unique and important functions. Among these T lymphocytes, NKT cells that express an invariant TCRα-chain and recognize lipid Ags presented by the nonclassical MHC class I molecule CD1d are probably the most studied ...
openaire   +2 more sources

CD4+/CD8+ mucosa-associated invariant T cells foster the development of endometriosis: a pilot study

Reproductive Biology and Endocrinology, 2019
Background Immune dysregulation is one of the mechanisms to promote endometriosis (EMS). Various T cell subpopulations have been reported to play different roles in the development of EMS.
Caihua Li, Zhimin Lu, Kaihuan Bi, Kangxia Wang, Yuping Xu, Peipei Guo, Ya Chen, Ping Zhou, Zhaolian Wei, Huanhuan Jiang, Yunxia Cao   +10 more
doaj   +1 more source

Mucosal-associated invariant T cells repress group 2 innate lymphoid cells in Alternaria alternata-induced model of allergic airway inflammation

Frontiers in Immunology, 2022
Mucosal-associated invariant T (MAIT) cells, a blossoming member of the innate-like T cells, play a pivotal role in host defense through engaging the mucosal immunity.
Yasuo Shimizu, Yasuo Shimizu, Yukiko Horigane-Konakai, Yoshii Ishii, Chie Sugimoto, Hiroshi Wakao   +5 more
doaj   +1 more source

Comparative transcriptomes reveal pro-survival and cytotoxic programs of mucosal-associated invariant T cells upon Bacillus Calmette–Guérin stimulation

Frontiers in Cellular and Infection Microbiology, 2023
Mucosal-associated invariant T (MAIT) cells are protective against tuberculous and non-tuberculous mycobacterial infections with poorly understood mechanisms. Despite an innate-like nature, MAIT cell responses remain heterogeneous in bacterial infections.
Manju Sharma, Liang Niu, Xiang Zhang, Shouxiong Huang   +3 more
doaj   +1 more source

Mucosal-associated invariant T (MAIT) cells produce growth factors and influence the regeneration of hepatic spheroids [PDF]

, 2022
openContesto: Il fegato è un importante sito immunologico che riceve prodotti batterici, tossine e antigeni di varia natura dal tratto gastrointestinale. Per operare una difesa efficace si basa principalmente su un solido sistema immunitario innato e il
TASIN, IRENE
core