Results 21 to 30 of about 29,619 (221)

IL7RA single nucleotide polymorphisms are associated with the size and function of the MAIT cell population in treated HIV-1 infection

Frontiers in Immunology, 2022
MAIT cells are persistently depleted and functionally exhausted in HIV-1-infected patients despite long-term combination antiretroviral therapy (cART). IL-7 treatment supports MAIT cell reconstitution in vivo HIV-1-infected individuals and rescues their ...
Fei Han, Fei Han, Muhammad Yaaseen Gulam, Yichao Zheng, Yichao Zheng, Nurul Syuhada Zulhaimi, Nurul Syuhada Zulhaimi, Wan Rong Sia, Dan He, Dan He, Amanda Ho, Amanda Ho, Leila Hadadi, Zhenyu Liu, Zhenyu Liu, Peiwu Qin, Peiwu Qin, Peter E. Lobie, Peter E. Lobie, Adeeba Kamarulzaman, Adeeba Kamarulzaman, Lin-Fa Wang, Johan K. Sandberg, Sharon R. Lewin, Reena Rajasuriar, Reena Rajasuriar, Reena Rajasuriar, Edwin Leeansyah, Edwin Leeansyah, Edwin Leeansyah, Edwin Leeansyah   +30 more
doaj   +1 more source

Alcohol Abstinence Does Not Fully Reverse Abnormalities of Mucosal-Associated Invariant T Cells in the Blood of Patients With Alcoholic Hepatitis [PDF]

, 2019
OBJECTIVES: Alcoholic hepatitis (AH) develops in approximately 30% of chronic heavy drinkers. The immune system of patients with AH is hyperactivated, yet ineffective against infectious diseases.
Bolte, Bottcher, Chan, Chayanupatkul, Chiba, Corbett, Cosgrove, Degre, Dhanda, Dusseaux, Eckle, Fergusson, Fung, Gao, Gao, Gerart, Hegde, Hengst, Jampana, Jeffery, Jiang, Kjer-Nielsen, Kurioka, Leclercq, Leeansyah, Leeansyah, Li, Liangpunsakul, Liangpunsakul, Loh, Markwick, Mutlu, Nagy, O'Shea, Pasala, Patel, Puri, Rao, Reantragoon, Riva, Saberi, Slichter, Spaan, Tang, Tilloy, Ussher, van Wilgenburg, Wong, Yong   +48 more
core   +1 more source

Check MAIT [PDF]

The Journal of Immunology, 2014
Abstract The evolutionary conservation of T lymphocyte subsets bearing αβ TCRs using invariant α-chains is indicative of unique and important functions. Among these T lymphocytes, NKT cells that express an invariant TCRα-chain and recognize lipid Ags presented by the nonclassical MHC class I molecule CD1d are probably the most studied ...
openaire   +2 more sources

CD4+/CD8+ mucosa-associated invariant T cells foster the development of endometriosis: a pilot study

Reproductive Biology and Endocrinology, 2019
Background Immune dysregulation is one of the mechanisms to promote endometriosis (EMS). Various T cell subpopulations have been reported to play different roles in the development of EMS.
Caihua Li, Zhimin Lu, Kaihuan Bi, Kangxia Wang, Yuping Xu, Peipei Guo, Ya Chen, Ping Zhou, Zhaolian Wei, Huanhuan Jiang, Yunxia Cao   +10 more
doaj   +1 more source

Mucosal-associated invariant T cells repress group 2 innate lymphoid cells in Alternaria alternata-induced model of allergic airway inflammation

Frontiers in Immunology, 2022
Mucosal-associated invariant T (MAIT) cells, a blossoming member of the innate-like T cells, play a pivotal role in host defense through engaging the mucosal immunity.
Yasuo Shimizu, Yasuo Shimizu, Yukiko Horigane-Konakai, Yoshii Ishii, Chie Sugimoto, Hiroshi Wakao   +5 more
doaj   +1 more source

Comparative transcriptomes reveal pro-survival and cytotoxic programs of mucosal-associated invariant T cells upon Bacillus Calmette–Guérin stimulation

Frontiers in Cellular and Infection Microbiology, 2023
Mucosal-associated invariant T (MAIT) cells are protective against tuberculous and non-tuberculous mycobacterial infections with poorly understood mechanisms. Despite an innate-like nature, MAIT cell responses remain heterogeneous in bacterial infections.
Manju Sharma, Liang Niu, Xiang Zhang, Shouxiong Huang   +3 more
doaj   +1 more source

Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection [PDF]

, 2012
Mucosa-associated invariant T (MAIT) cells are a unique population of αβ T cells in mammals that reside preferentially in mucosal tissues and express an invariant Vα paired with limited Vβ T-cell receptor (TCR) chains.
Andersen, Annibali, Azra Blazevic, Berrington, Berzins, Billerbeck, Borg, Brennan, Brigl, Brigl, Chiba, Cho, Christopher S. Eickhoff, Chua, Chua, Cogen, Cohen, Cooper, Cooper, Cowley, Cowley, Croxford, Cua, Curtis, D'Souza, D'Souza, Daniel F. Hoft, Dusseaux, Elkins, Feng, Flesch, Flynn, Flynn, Gansert, Georgel, Gold, Gold, Goldfinch, Gopal, Green, Hansen, Huang, Huang, Huang, J. L. Flynn, Jovanovic, Junqueira-Kipnis, Kariyone, Kawachi, Khader, Khader, Kinjo, Ladel, Le Bourhis, Lin, Lockhart, Lozes, MacMicking, Martin, Miley, Misko, Miyazaki, Nagarajan, Parker, Parra, Pollock, Qian, Riegert, Rodgers, Sada-Ovalle, Schoenborn, Shimamura, Skold, Sousa, Steven M. Truscott, Ted H. Hansen, Tilloy, Treiner, Treiner, Tupin, Tyznik, Urdahl, Wei-Jen Chua, Worku, Yamaguchi, Yamaguchi, Zhang   +86 more
core   +2 more sources

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers [PDF]

, 2015
Studies on the biology of mucosal-associated invariant T cells (MAIT cells) in mice have been hampered by a lack of specific reagents. Using MR1-antigen (Ag) tetramers that specifically bind to the MR1-restricted MAIT T cell receptors (TCRs), we ...
Chen, Zhenjun, Clanchy, Rhiannon, Eckle, Sidonia B. G., Enders, Anselm, Fairlie, David P., Godfrey, Dale I., Goodnow, Chris C., Koay, Hui Fern, Liu, Ligong, McCluskey, James, Meehan, Bronwyn, Pellicci, Daniel G., Rahimpour, Azad, Rossjohn, Jamie, Uldrich, Adam P., Whittle, Belinda   +15 more
core   +3 more sources

The role of mucosal-associated invariant T cells in visceral leishmaniasis

Frontiers in Immunology, 2022
Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by ...
Marcela de Lima Moreira, Marcela de Lima Moreira, Luana Oliveira Borges-Fernandes, Marcelo Antônio Pascoal-Xavier, Marcelo Antônio Pascoal-Xavier, Ágata Lopes Ribeiro, Victória Hellena Silva Pereira, Troi Pediongco, Márcio Sobreira da Silva Araújo, Andréa Teixeira-Carvalho, Andrea Lucchesi de Carvalho, Maria Vitória Assumpção Mourão, Flávia Alves Campos, Marineide Borges, Mariângela Carneiro, Zhenjun Chen, Eleanor Saunders, Malcolm McConville, Moriya Tsuji, James McCluskey, Olindo Assis Martins-Filho, Sidonia Barbara Guiomar Eckle, Jordana Grazziela Alves Coelho-dos-Reis, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhães   +24 more
doaj   +1 more source

Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes [PDF]

, 2017
Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction of pancreatic β-cells by the immune system that involves innate and adaptive immune cells.
Battaglia, Manuela, Beaudoin, Lucie, Beltrand, Jacques, Cagninacci, Lucie, Corbett, Alexandra, Da silva, Jennifer, Diedisheim, Marc, Kiaf, Badr, Lantz, Olivier, Lehuen, Agnès, McCluskey, James, Nel, Isabelle, Oshima, Masaya, Polak, Michel, Rossjohn, Jamie, Rouxel, Ophélie, Salou, Marion, Scharfmann, Raphael, Tard, Céline   +18 more
core   +4 more sources