Results 31 to 40 of about 7,761 (187)

MICADO SCAO: to be or not to be... in MAIT

, 2023
MICADO is the ELT first light instrument, an imager working at the diffraction limit of the telescope thanks to two adaptive optics (AO) modes: a single conjugate one (SCAO), available at the instrument first light and developed by the MICADO consortium, and a multi conjugate one (MCAO), developed by the MORFEO consortium.
Clenet, Yann, Buey, Tristan, Gendron, Eric, Karkar, Sonia, Vidal, Fabrice, Cohen, Mathieu, Chapron, Frédéric, Sevin, Arnaud, Thijs, Simone, Taburet, Sylvestre, Borgo, Bruno, Huet, Jean-Michel, Blin, Alexandre, Dupuis, Olivier, Gaudemard, Julien, Ferreira, Florian, Raffard, Jordan, Chemla, Fanny, Lapeyrère, Vincent, Guieu, Sylvain, Meyer, Eric, Gautherot, Nicolas, Tisserand, Emmanuel, Locatelli, Hervé, Meyer, François, Genet, Camille, Cloiseau, Kévin, Zidi, Amal, Kulcsár, Caroline, Raynaud, Henri-François, Sassolas, Benoît, Pinard, Laurent, Michel, Christophe, Gratadour, Damien, Dembet, Roderick, Collin, Claude, Ghouchou, Lahoucine, Baudoz, Pierre, Huby, Elsa, Rabien, Sebastian, Sturm, Eckhard, Davies, Ric   +41 more
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MAIT cells in liver inflammation and fibrosis

Seminars in Immunopathology, 2022
AbstractMucosal-associated invariant T cells or MAIT cells are an abundant cell type in humans and especially so in the liver. MAIT cells are a subset of T lymphocytes that sit at a bridge between innate and adaptive immunity, so-called innate-like or “unconventional” T cells.
Mehta, H, Lett, MJ, Klenerman, P, Filipowicz Sinnreich, M   +3 more
openaire   +2 more sources

When it’s good to have MAITs [PDF]

Immunology & Cell Biology, 2020
This article discusses mucosal-associated invariant T-cell prophylactic and therapeutic vaccination schemes tested by Sakai et al. in mouse models of Mycobacterium tuberculosis infection together with the outcomes and observations.
Souter, MNT, McCluskey, J, Corbett, AJ
openaire   +3 more sources

iNKT and MAIT Cell Alterations in Diabetes [PDF]

Frontiers in Immunology, 2015
Type 1 diabetes (T1D) and type 2 diabetes (T2D) are multifactorial diseases with different etiologies in which chronic inflammation takes place. Defects in invariant natural killer T (iNKT) cell populations have been reported in both T1D and T2D patients, mouse models and our recent study revealed mucosal-associated invariant T (MAIT) cell defects in ...
Magalhaes, Isabelle, Kiaf, Badr, Lehuen, Agnès   +2 more
openaire   +4 more sources

Mucosal-Associated Invariant T Cell Features and TCR Repertoire Characteristics During the Course of Multiple Sclerosis

Frontiers in Immunology, 2019
Objective: To investigate the frequency, phenotype, function, and longitudinal repertoire of mucosal-associated invariant T (MAIT) cells in relapsing remitting multiple sclerosis (RRMS) and primary progressive multiple sclerosis (PPMS) patients.Methods ...
Edgar Carnero Contentti, Mauricio F. Farez, Jorge Correale, Jorge Correale   +3 more
doaj   +1 more source

Human MAIT Cell Activation In Vitro [PDF]

, 2019
Mucosal-associated invariant T (MAIT) cells are an abundant innate-like T cell subset in humans, enriched in mucosal tissues and the liver. MAIT cells express a semi-invariant T cell receptor (TCR) and recognize microbial-derived riboflavin metabolites presented on the MHC Class I-like molecule MR1. In addition to activation via the TCR, MAIT cells can
Hagel, JP, Garner, LC, Bilton, M, Mehta, H, Leng, T, Hackstein, C-P, Phalora, P, Amini, A, Akther, HD, Provine, NM, Edmans, M, Willberg, CB, Klenerman, P   +12 more
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Biological functions of MAIT cells in tissues

Molecular Immunology, 2021
Mucosal associated invariant T (MAIT) cells have a recognised innate-like capacity for antibacterial host defence, consequent on the specificity of their T cell receptor (TCR) for small molecule metabolites produced by a range of prokaryotic and fungal species, their effector memory phenotype, and their expression of cytotoxic molecules.
Klenerman, Paul, Hinks, Timothy S.C., Ussher, James E.   +2 more
openaire   +2 more sources

Mucosal Associated Invariant T cells in the human gastric mucosa and blood: Role in Helicobacter pylori infection

Frontiers in Immunology, 2015
Mucosal-associated invariant T (MAIT) cells represent a class of antimicrobial innate-like T cells that have been characterized in human blood, liver, lungs and intestine.
Jayaum S Booth, Jayaum S Booth, Rosangela eSalerno-Goncalves, Rosangela eSalerno-Goncalves, Thomas G Blanchard, Seema A. Patil, Seema A. Patil, Howard A. Kader, Anca M. Safta, Lindsay M. Morningstar, Steven J. Czinn, Bruce D. Greenwald, Bruce D. Greenwald, Marcelo B. Sztein, Marcelo B. Sztein, Marcelo B. Sztein   +15 more
doaj   +1 more source

Clinicopathological and predictive value of MAIT cells in non-small cell lung cancer for immunotherapy

Journal for ImmunoTherapy of Cancer, 2023
Background Immune-checkpoint inhibitors (ICIs) remain ineffective in a large group of non-small cell lung cancer (NSCLC) patients. Mucosal-associated invariant T (MAIT) cells, a population of unconventional innate-like T lymphocytes abundant in the human
Dongyan Shi, Lin Lin, Yun Chen, Jian Liu, Lin Shi, Jinying Lu, Da Zhong, Meijuan Song, Wenhua You, Wen-Hui Li   +9 more
doaj   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source