Results 51 to 60 of about 29,619 (221)

Molecular analyses define Vα7.2-Jα33+ MAIT cell depletion in HIV infection: a case-control study [PDF]

, 2015
Mucosal-associated invariant T (MAIT) cells are an abundant antibacterial innate-like lymphocyte population. There are conflicting reports as to their fate in HIV infection.
Cosgrove, Cormac, Goulder, Philip, Günthard, Huldrych F, Hannaway, Rachel F, Klenerman, Paul, Phalora, Prabhjeet, Phillips, Rodney E, Rauch, Andri, Ussher, James E, Willberg, Christian B   +9 more
core   +2 more sources

Activation and Functional Alteration of Mucosal-Associated Invariant T Cells in Adult Patients With Community-Acquired Pneumonia

Frontiers in Immunology, 2021
Community-acquired pneumonia (CAP) remains the significant infectious cause of morbidity and mortality worldwide. Although mucosal-associated invariant T cells (MAIT) play roles in the pathogenesis of children CAP and ICU-associated pneumonia, their ...
Lichen Ouyang, Lichen Ouyang, Mi Wu, Zhijun Shen, Xue Cheng, Wei Wang, Lang Jiang, Juan Zhao, Yeli Gong, Zhihui Liang, Xiufang Weng, Muqing Yu, Xiongwen Wu   +12 more
doaj   +1 more source

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +2 more sources

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells [PDF]

, 2013
Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TCR) alpha-chain, TRAV1-2-TRAJ33, and are activated by vitamin B metabolites bound by the major histocompatibility complex (MHC)-related class I-like molecule ...
Birkinshaw, Richard W., Chen, Zhenjun, Corbett, Alexandra J., Eckle, Sidonia B. G., Fairlie, David P., Furness, John B., Gherardin, Nicholas A., Godfrey, Dale I., Hansen, Ted H., Kedzierska, Katherine, Kjer-Nielsen, Lars, Kostenko, Lyudmila, Liu, Ligong, McCluskey, James, Meehan, Bronwyn, Patel, Onisha, Reantragoon, Rangsima, Rossjohn, Jamie, Sakala, Isaac G., Uldrich, Adam P.   +19 more
core   +3 more sources

Recognition of vitamin B metabolites by mucosal-associated invariant T cells [PDF]

, 2013
The mucosal-associated invariant T-cell antigen receptor (MAIT TCR) recognizes MR1 presenting vitamin B metabolites. Here we describe the structures of a human MAIT TCR in complex with human MR1 presenting a non-stimulatory ligand derived from folic acid
A Bendelac, AG Leslie, AW Schuttelkopf, C Cosgrove, DG Pellicci, DI Godfrey, DI Godfrey, DI Godfrey, DI Godfrey, DN Garboczi, E Girardi, E Girardi, E Leeansyah, E Treiner, F Tilloy, FE Tynan, G Vera, J Rossjohn, KS Wun, L Kjer-Nielsen, L Kjer-Nielsen, L Le Bourhis, L Le Bourhis, MC Gold, MC Gold, NA Borg, O Patel, PH Zwart, R Reantragoon, S Gras, S Huang, S Huang, SJ Turner, TS Mikkelsen, WJ Chua, X-Z Tang, Y Miyazaki   +36 more
core   +1 more source

Cryoablation Activates the cGAS–STING‐CXCL10 Axis in Macrophages to Enhance Anti‐Tumor Immunity in NSCLC

Advanced Science, EarlyView.
Tumor dsDNA released by cryoablation is taken up by macrophages, activating the cGAS‐STING signaling pathway. This leads to an expansion of the CXCL10+ macrophage pool and increased secretion of CXCL10, which in turn recruits CXCR3+ T cells from draining lymph nodes into the tumor microenvironment to exert anti‐tumor effects.
Xinxin Zhi, Zhengcao Xing, Libo Luo, Jiale Wang, Xinyu Liu, Jia Yu, Jizhong Yin, Bin Chen, Yiwei Liu, Hui Sun, Guanghui Gao, Lei Wang, Xiaoxia Chen, Fei Li, Hu Ma, Lin Wang, Shuo Yang, Shengxiang Ren   +17 more
wiley   +1 more source

Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells, defined as CD161++TCR iVα7.2+ T cells, play an important role in the innate defense against bacterial infections, and their functionality is impaired in chronic viral infections.
Yean K. Yong, Yean K. Yong, Yean K. Yong, Alireza Saeidi, Hong Y. Tan, Hong Y. Tan, Hong Y. Tan, Hong Y. Tan, Mohamed Rosmawati, Philip F. Enström, Rami Al Batran, V. Vasuki, Indranil Chattopadhyay, Amudhan Murugesan, Ramachandran Vignesh, Adeeba Kamarulzaman, Adeeba Kamarulzaman, Jayakumar Rajarajeswaran, Abdul W. Ansari, Jamuna Vadivelu, James E. Ussher, Vijayakumar Velu, Marie Larsson, Esaki M. Shankar, Esaki M. Shankar, Esaki M. Shankar   +25 more
doaj   +1 more source

An R package to analyse LC/MS metabolomic data: MAIT (Metabolite Automatic Identification Toolkit) [PDF]

, 2017
Current tools for liquid chromatography and mass spectrometry for metabolomic data cover a limited number of processing steps, whereas online tools are hard to use in a programmable fashion. This article introduces the Metabolite Automatic Identification
Andrés Lacueva, Ma. Cristina, Fernández Albert, Francesc, Llorach, Rafael, Perera Lluna, Alexandre   +3 more
core   +1 more source

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Hantaan virus infection induces human mucosal-associated invariant T cell pyroptosis through IRE1α pathway

Communications Biology
Hantaan virus (HTNV) triggers an epidemic of hemorrhagic fever with renal syndrome (HFRS), which is predominantly prevalent in Asia. Mucosal-associated invariant T (MAIT) cells, categorized as innate-like T lymphocytes, perform crucial functions in the ...
Yusi Zhang, He Liu, Dalu Liu, Huiyuan Zhang, Ying Ma, Na Li, Chunmei Zhang, Manling Xue, Fenglan Wang, Xiaozhou Jia, Hui Zhang, Kang Tang, Xiaoyue Xu, Shijia Wang, Yiwen Wei, Xiaojing Yang, Jiajia Zuo, Lihua Chen, Boquan Jin, Yun Zhang   +19 more
doaj   +1 more source