Results 51 to 60 of about 10,390 (221)

Activation and Functional Alteration of Mucosal-Associated Invariant T Cells in Adult Patients With Community-Acquired Pneumonia

Frontiers in Immunology, 2021
Community-acquired pneumonia (CAP) remains the significant infectious cause of morbidity and mortality worldwide. Although mucosal-associated invariant T cells (MAIT) play roles in the pathogenesis of children CAP and ICU-associated pneumonia, their ...
Lichen Ouyang, Lichen Ouyang, Mi Wu, Zhijun Shen, Xue Cheng, Wei Wang, Lang Jiang, Juan Zhao, Yeli Gong, Zhihui Liang, Xiufang Weng, Muqing Yu, Xiongwen Wu   +12 more
doaj   +1 more source

Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells, defined as CD161++TCR iVα7.2+ T cells, play an important role in the innate defense against bacterial infections, and their functionality is impaired in chronic viral infections.
Yean K. Yong, Yean K. Yong, Yean K. Yong, Alireza Saeidi, Hong Y. Tan, Hong Y. Tan, Hong Y. Tan, Hong Y. Tan, Mohamed Rosmawati, Philip F. Enström, Rami Al Batran, V. Vasuki, Indranil Chattopadhyay, Amudhan Murugesan, Ramachandran Vignesh, Adeeba Kamarulzaman, Adeeba Kamarulzaman, Jayakumar Rajarajeswaran, Abdul W. Ansari, Jamuna Vadivelu, James E. Ussher, Vijayakumar Velu, Marie Larsson, Esaki M. Shankar, Esaki M. Shankar, Esaki M. Shankar   +25 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Mucosal-Associated Invariant T Cells Redistribute to the Peritoneal Cavity During Spontaneous Bacterial Peritonitis and Contribute to Peritoneal InflammationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Mucosal-associated invariant T (MAIT) cells are depleted from blood in patients with advanced liver disease and show features of immune dysfunction.
Oluwatomi Ibidapo-obe, Sven Stengel, Nilay Köse-Vogel, Stefanie Quickert, Philipp A. Reuken, Martin Busch, Michael Bauer, Andreas Stallmach, Tony Bruns   +8 more
doaj   +1 more source

The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation

American Journal of Hematology, EarlyView.
ABSTRACT Allogeneic hematopoietic cell transplantation (allo‐HCT) is an effective treatment for patients with high‐risk hematologic malignancies. Over the last decade, gut microbiota composition during allo‐HCT has been associated with patients' outcomes.
Wenjing Hao, Nicolas Stocker, Béatrice Gaugler, Mohamad Mohty, Florent Malard   +4 more
wiley   +1 more source

Hantaan virus infection induces human mucosal-associated invariant T cell pyroptosis through IRE1α pathway

Communications Biology
Hantaan virus (HTNV) triggers an epidemic of hemorrhagic fever with renal syndrome (HFRS), which is predominantly prevalent in Asia. Mucosal-associated invariant T (MAIT) cells, categorized as innate-like T lymphocytes, perform crucial functions in the ...
Yusi Zhang, He Liu, Dalu Liu, Huiyuan Zhang, Ying Ma, Na Li, Chunmei Zhang, Manling Xue, Fenglan Wang, Xiaozhou Jia, Hui Zhang, Kang Tang, Xiaoyue Xu, Shijia Wang, Yiwen Wei, Xiaojing Yang, Jiajia Zuo, Lihua Chen, Boquan Jin, Yun Zhang   +19 more
doaj   +1 more source

The role of mucosal associated invariant T cells in antimicrobial immunity

Frontiers in Immunology, 2015
Mucosal associated invariant T (MAIT) cells are an innate-like T cell subset prevalent in humans and distributed throughout the blood and mucosal sites. Human MAIT cells are defined by the expression of the semi-invariant TCRα chain TRAV1-2/TRAJ12/20/33 ...
Ruth J Napier, Erin J Adams, Erin J Adams, Erin J Adams, Marielle C Gold, Marielle C Gold, Marielle C Gold, David M Lewinsohn, David M Lewinsohn, David M Lewinsohn   +9 more
doaj   +1 more source

MAIT Cells in Type 1 Diabetes Mouse Models

, 2019
International audienceMAIT cells are unconventional T cells expressing a semi-invariant αβ TCR, and they recognize bacterial metabolites via the highly conserved MR1 protein.
Beaudoin, Lucie, Nel, Isabelle, Lehuen, Agnès, Lucie Beaudoin, Isabelle Nel, Agnès Lehuen   +5 more
core   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Frequencies of CD8 and DN MAIT Cells Among Children Diagnosed With Type 1 Diabetes Are Similar to Age-Matched Controls

Frontiers in Immunology, 2021
Mucosal-associated invariant T (MAIT) cells have been implicated in various forms of autoimmunity, including type 1 diabetes (T1D). Here, we tested the hypothesis that CD8 and double negative (DN) MAIT cell frequencies were altered among diagnosed T1D ...
Robert Z. Harms, Katie R. Ostlund, Monina Cabrera, Monina Cabrera, Earline Edwards, Earline Edwards, Victoria B. Smith, Lynette M. Smith, Nora Sarvetnick, Nora Sarvetnick   +9 more
doaj   +1 more source