Results 71 to 80 of about 7,761 (187)

MAIT Cells in Liver Disease

Cells
Mucosal-associated invariant T (MAIT) cells are abundant innate-like T lymphocytes in the human liver which can provide antimicrobial defense, amplify inflammatory processes and mediate tissue repair and fibrosis depending on microenvironmental cues.
Adiba I. Azad, Florencia Gutierrez, Gregory J. Gores   +2 more
openaire   +3 more sources

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

Synovial Fluid Immune Cell Landscape in Juvenile Idiopathic Arthritis

European Journal of Immunology, Volume 56, Issue 10, October 2026.
Synovial fluid immune cells in juvenile idiopathic arthritis were profiled using single‐cell multiomics and flow cytometry. The immune landscape in synovial fluid was markedly distinct from that of blood and was enriched for dendritic cells, CD56hi NK cells, γδ T cells, CD4+ T peripheral helper and regulatory T cells, tissue‐resident memory CD8+ T ...
Viola Pitkänen, Bella Lappalainen, Marja Rytkönen‐Nissinen, Terhi Remes‐Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna‐Maija Grönlund, Miika Arvonen, Liisa Kröger, Anna‐Mari Schroderus, Tuure Kinnunen   +10 more
wiley   +1 more source

IFN‐γ‐Associated Signaling Networks in Interstitial Lung Disease Associated With Sjögren's Disease

Immunity, Inflammation and Disease, Volume 14, Issue 10, October 2026.
ABSTRACT Background Sjögren's disease (SD) is a chronic systemic autoimmune disorder that can affect multiple organ systems. Interstitial lung disease (ILD) is a clinically significant pulmonary manifestation of SD and is associated with impaired quality of life and increased mortality.
Qianqian Chen, Yuhan Li, Yiming Chen, Yuhua Su, Xiaodong Wang, Chunxiao Guan   +5 more
wiley   +1 more source

A Distinct Immune Signature Characterizes Cirrhosis in Ethiopian Individuals With Chronic HBV Infection

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 7, Page 951-964, October 2026.
Cirrhosis patients with untreated HBV in Ethiopia exhibit a distinct immune profile marked by depletion of NK cells, B cells, and T cells, alongside an expanded CD38+HLA‐DR+ CD8 T‐cell population. ABSTRACT Background and Aims The immune cell phenotype of African patients living with chronic hepatitis B virus (HBV) infection is rarely described, despite
Julia MacLeod, Fikadu G. Gudissa, Asiya Jeylan, Nega Berhe, Hailemichael Desalegn, Lasse Rossvoll, Asgeir Johannessen, Niklas K. Björkström, Dag Henrik Reikvam, Annika Niehrs   +9 more
wiley   +1 more source

Entering the Age of Specificity in T Cell Immunity

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT The discovery of MHC restriction, the resolution of peptide–MHC structure, and the identification of the T cell receptor gene quickly centered epitope‐level specificity as a core concern of T cell biology. Epitope mapping culminated in functional peptide‐based stimulation assays and tetramer staining, which together provide exquisite ...
Paul G. Thomas
wiley   +1 more source

Increased pathogenicity and pro-inflammatory capabilities of mucosal-associated invariant T cells involved in Oral Lichen Planus

BMC Oral Health
Background Mucosal-associated invariant T (MAIT) cells assume pivotal roles in numerous autoimmune inflammatory maladies. However, scant knowledge exists regarding their involvement in the pathological progression of oral lichen planus (OLP).
Siting Chen, Xiaoli Wu, Yinshen Yang, Xiaoheng Xu, Xiaoqin Xiong, Wenxia Meng   +5 more
doaj   +1 more source

Mice Generated with Induced Pluripotent Stem Cells Derived from Mucosal-Associated Invariant T Cells

Biomedicines
The function of mucosal-associated invariant T (MAIT) cells, a burgeoning member of innate-like T cells abundant in humans and implicated in many diseases, remains obscure.
Chie Sugimoto, Hiroyoshi Fujita, Hiroshi Wakao   +2 more
doaj   +1 more source

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

Nature Communications, 2017
MAIT cells are activated by MR1 restricted antigens derived from riboflavin biosynthesis. Here the authors characterize MAIT cell antigenicity and synthesize a water stable antigen that activates human MAIT cellsin vitro and mouse MAIT cells in vivo.
Jeffrey Y. W. Mak, Weijun Xu, Robert C. Reid, Alexandra J. Corbett, Bronwyn S. Meehan, Huimeng Wang, Zhenjun Chen, Jamie Rossjohn, James McCluskey, Ligong Liu, David P. Fairlie   +10 more
doaj   +1 more source

Liver transplant-facilitated CD161+Vα7.2+ MAIT cell recovery demonstrates clinical benefits in hepatic failure patients

Nature Communications
Mucosal-associated invariant T (MAIT) cells exert multifaceted effects such as anti-microbial activity, tissue repair, and pro-fibrotic effects across various disease settings. Nonetheless, their role in liver injury and hemostasis remains debated. Here,
Wei Wang, Chen Dai, Peng Zhu, Mi Wu, Haoquan Zhang, Qing Wei, Ting Zhou, Xiaosheng Tan, Ying Jiang, Xue Cheng, Zhihui Liang, Xiongwen Wu, Zhishui Chen, Xiufang Weng   +13 more
doaj   +1 more source