Results 71 to 80 of about 10,390 (221)

MAIT cells regulate NK cell-mediated tumor immunity [PDF]

, 2021
The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT cell-deficient mice have enhanced NK cell-dependent control of metastatic B16F10 tumor growth relative to control mice ...
Todd, KL, Kearney, CJ, Oliver, AJ, Pizzolla, A, Godfrey, DI, Li, J, Millen, R, McCulloch, TR, Chen, AXY, Oliaro, J, Giuffrida, L, Beavis, PA, Ramsay, RG, Mak, JYW, Petley, EV, Lai, J, Sek, K, Souza-Fonseca-Guimaraes, F, Michie, J, McCluskey, J, Keam, SP, Koay, HF, Fairlie, DP, Neeson, PJ, Zethoven, M, Freeman, AJ, House, IG, Darcy, PK, Huntington, ND, Henderson, MA, Chan, JD   +30 more
core   +1 more source

T Cell Heterogeneity Shaped by Alternative Splicing Predicts Prognosis in Hepatocellular Carcinoma

Cancer Science, EarlyView.
T cell‐specific alternative splicing events shape T cell heterogeneity in HCC. Single‐cell analysis identified two splicing‐defined T cell subpopulations with distinct functional profiles. Subpopulation‐associated splicing events were used to construct a prognostic model predicting patient survival.
Xiaohui Peng, Zhenli Li, Xiuqing Dong, Zhixiong Cai, Chenfan Lu, Junjie Gao, Shuyue You, Yuwen Wang, Jianming Mao, Xiaolong Liu, Geng Chen, Yingchao Wang   +11 more
wiley   +1 more source

Molecular Analyses Define Vα7.2-Jα33+ MAIT Cell Depletion in HIV Infection: A Case-Control Study [PDF]

, 2015
Mucosal-associated invariant T (MAIT) cells are an abundant antibacterial innate-like lymphocyte population. There are conflicting reports as to their fate in HIV infection.
Cosgrove, Cormac, Goulder, Philip, Günthard, Huldrych F, Cosgrove, C, Rauch, A, Willberg, CB, Ussher, James E, Phalora, Prabhjeet, Hannaway, Rachel F, Rauch, Andri, Phillips, Rodney E, Ussher, JE, Klenerman, Paul, Phalora, P, Günthard, HF, Klenerman, P, Goulder, P, Willberg, Christian B, Hannaway, R, Phillips, RE   +19 more
core   +1 more source

Single Cell Multi‐Omics Revealing the Important Role of MR1 Mediated MAIT Cells in Maintaining Rejection for Liver Transplantation

Cell Proliferation, EarlyView.
This multi‐omics study reveals the significant role of MAIT cells in liver transplant rejection. MAIT cells drive rejection in liver transplantation via the MR1 axis. Their absence reshapes T cell responses and clonal expansion, attenuating allograft injury.
Hailun Cai, Xinqiang Li, Xin Zhou, Xueteng Wang, Zhuoyu Jia, Ruidong Ding, Yurong Luo, Ye Wang, Shipeng Li, Wenxing Sun, Dongxing Wu, Dahong Teng, Kai Zhao, Guanghui Pei, Jinzhen Cai, Bin Wu   +15 more
wiley   +1 more source

Clinicopathological and predictive value of MAIT cells in non-small cell lung cancer for immunotherapy

Journal for ImmunoTherapy of Cancer, 2023
Background Immune-checkpoint inhibitors (ICIs) remain ineffective in a large group of non-small cell lung cancer (NSCLC) patients. Mucosal-associated invariant T (MAIT) cells, a population of unconventional innate-like T lymphocytes abundant in the human
Dongyan Shi, Lin Lin, Yun Chen, Jian Liu, Lin Shi, Jinying Lu, Da Zhong, Meijuan Song, Wenhua You, Wen-Hui Li   +9 more
doaj   +1 more source

Mouse models illuminate MAIT cell biology

, 2021
The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification of the vitamin-B-based antigens recognised by these specialised T cells.
Wang, H, Chen, Z, Corbett, AJ, McCluskey, J   +3 more
core   +1 more source

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source

MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis

International audienceIntestinal inflammation shifts microbiota composition and metabolism. How the host monitors and responds to such changes remains unclear.
Perrin, Laetitia, Mondot, Stanislas, Premel, Virginie, Franciszkiewicz, Katarzyna, Maurin, Mathieu, Mestdagh, Martin, Procopio, Emanuele, Furstenheim, Mariela, Dupré, Thierry, Lantz, Olivier, El Morr, Yara, Richon, Sophie, Legoux, Francois, Rodriguez, Raphaël, Salou, Marion, Bugaut, Helene, Colombeau, Ludovic, Philippe, Catherine, Darbois, Aurelie, Vorobev, Alexey, Morvan, Claire, Jneid, Bakhos, Du Halgouet, Anastasia   +22 more
core   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Development and Functions of MAIT Cells

Annual Review of Immunology
Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved T cells that recognize microbial metabolites. They are abundant in humans and conserved during mammalian evolution, which suggests that they have important nonredundant functions.
Salou, Marion, Paiva, Rafael A., Lantz, Olivier   +2 more
openaire   +2 more sources