Results 91 to 100 of about 10,390 (221)

Factors Influencing Functional Heterogeneity in Human Mucosa-Associated Invariant T Cells

Frontiers in Immunology, 2018
Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites presented by the monomorphic MHC class I-related (MR1) molecule.
Joana Dias, Caroline Boulouis, Michał J. Sobkowiak, Kerri G. Lal, Kerri G. Lal, Kerri G. Lal, Johanna Emgård, Marcus Buggert, Tiphaine Parrot, Jean-Baptiste Gorin, Edwin Leeansyah, Edwin Leeansyah, Johan K. Sandberg   +12 more
doaj   +1 more source

Multi‐omics insights for deciphering prognosis‐related T cell subsets in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
An integrated multi‐omics analysis delineates the prognostic landscape of T‐cell subsets in hepatocellular carcinoma. DPT cells and HBEGF‐related signals are associated with poor survival in hepatocellular carcinoma. Endothelial‐derived HBEGF recruits DPT cells, which in turn up‐regulate the EMT signatures and drive the migration of hepatocellular ...
Guangzu Cui, Erya Hu, Qingping Peng, Xin Zhou, Yu Zhao, Haicong Liu, Xinwen Wang, Yihong Chen, Hong Shen, Shan Zeng, Jiayao Ma   +10 more
wiley   +1 more source

CD8 MAIT cells and HIV disease progression.

, 2016
(A) Correlation between CD8+ MAIT cells and %CD4+ T cells in HIV+ (filled circles) and HIV- (open circles) children. (B) Percent CD8+ MAIT cells vs. HIV log copies/mL in viremic HIV+ children.
Cihan Tastan (3079533), Tiina Ilmet (3079542), Max Kilberg (3079539), William Borkowsky (591602), Adam Kravietz (3079530), Derya Unutmaz (52436), Mengling Liu (136610), Mussa Mwamzuka (3079536), Aabid Ahmed (3079545), Alka Khaitan (3079527), Fatma Marshed (3079524)   +10 more
core   +1 more source

Monkeying around with MAIT Cells: Studying the Role of MAIT Cells in SIV and Mtb Co-Infection

, 2021
There were an estimated 10 million new cases of tuberculosis (TB) disease in 2019. While over 90% of individuals successfully control Mycobacterium tuberculosis (Mtb) infection, which causes TB disease, HIV co-infection often leads to active TB disease ...
Ryan V. Moriarty, Amy L. Ellis, Shelby L. O’Connor   +2 more
core   +1 more source

MAIT cell biology in context of liver transplantation

, 2021
Das 1-Jahres-Überleben von lebertransplantierten PatientInnen hat sich in den letzten 30 Jahren aufgrund der Einführung neuer Immunsuppressiva (IS) deutlich verbessert.
Thiel, Lion, Thiel, Lion Gabriel
core   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

A conserved transcriptional program for MAIT cells across mammalian evolution

International audienceMucosal-associated invariant T (MAIT) cells harbor evolutionarily conserved TCRs, suggesting important functions. As human and mouse MAIT functional programs appear distinct, the evolutionarily conserved MAIT functional features ...
A. Paiva, Rafael, Mestdagh, Martin, Chaiyasitdhi, Atitheb, Piquet, Julie, Legoux, Francois, Smadja, David M, Maciulyte, Valdone, Darbois, Aurelie, El Marjou, Ahmed, Montagutelli, Xavier, Perrin, Laetitia, Bernardeau, Karine, Mutala, Linda, Bilonda, Ryffel, Bernhard, Cieslak, Agata, Furstenheim, Mariela, Turner, James M. A., Lantz, Olivier, El Morr, Yara, Guerin, Coralie, Bugaut, Helene, Salou, Marion, Du Halgouet, Anastasia, Le Gac, Anne‐laure, Arnaud, Manon   +24 more
core   +1 more source

MAIT cells protect against pulmonary Legionella longbeachae infection [PDF]

, 2018
Mucosal associated invariant T (MAIT) cells recognise conserved microbial metabolites from riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate them in antibacterial host defence, yet their functions in protection ...
Fairlie, David P., Hinks, Timothy S.C., Godfrey, DI, Wang, Huimeng, Wang, Nancy, Pediongco, TJ, Godfrey, Dale I., Kjer-Nielsen, Lars, Westall, Glen P., Meehan, BS, Mak, JYW, Corbett, AJ, Hinks, Timothy S. C., D'Souza, C, Iwakura, Y, Eckle, Sidonia B. G., Shi, Mai, Eckle, Sidonia B.G., Kostenko, L, Eckle, SBG, Strugnell, RA, Gunnersen, JM, Meehan, Bronwyn S., D’Souza, C, Rossjohn, Jamie, Kjer-Nielsen, L, Hinks, Timothy Stopford, D'Souza, Criselle, Chen, Z, Mak, Jeffrey Y.W., Liu, Ligong, Pediongco, Troi J., Gunnersen, Jennifer M., McCluskey, James, Shi, M, Westall, GP, Liu, L, Stent, AW, Lim, Xin Yi, Wang, H, D’Souza, Criselle, Hinks, TSC, Wang, N, Chen, Zhenjun, McCluskey, J, Lim, X, Fairlie, DP, Rossjohn, J, Corbett, Alexandra J., Strugnell, Richard A., Kostenko, Lyudmila, Stent, Andrew W., Mak, Jeffrey Y. W., Li, Shihan, Iwakura, Yoichiro, Li, S, Lim, XY   +56 more
core   +1 more source

Vascular Immune Remodeling: A CD4+ T Cell–Driven Immune Trajectory Associated With Arterial Stiffness

Aging Cell, Volume 25, Issue 6, June 2026.
This study integrated arterial stiffness with peripheral TCRβ repertoire and single‐cell transcriptomics in adults without cardiovascular disease, revealing a CD4+ T cell–driven “vascular immune remodeling” trajectory distinct from classical immunosenescence: increased TCR diversity, broad expansion of low‐frequency public clones and virus‐associated ...
Yu Miao, Bangwei Chen, Changqing Zeng, Xiaofen Wu, Minglei Yang, Cuntai Zhang, Jianguo Zhang, Yutao Du, Tao Li, Lei Ruan   +9 more
wiley   +1 more source

T‐Cell Biology in the Female Reproductive Tract: Relevance to HIV Infection

American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.
ABSTRACT Worldwide, most HIV infections occur across a mucosal surface during sexual contact, with women accounting for nearly half of reported new HIV infections across the globe in 2024. Most new infections in women and girls are believed to involve transmission across mucosal surfaces of the lower reproductive tract, which includes the vagina and ...
Barbara L. Shacklett, Ramatoulaye H. Ouattara, April L. Ferre   +2 more
wiley   +1 more source