Results 81 to 90 of about 7,761 (187)

Lymphocytes MAIT

médecine/sciences, 2023
Morgane Mabire, Hélène Gilgenkrantz, Sophie Lotersztajn   +2 more
openaire   +1 more source

Factors Influencing Functional Heterogeneity in Human Mucosa-Associated Invariant T Cells

Frontiers in Immunology, 2018
Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites presented by the monomorphic MHC class I-related (MR1) molecule.
Joana Dias, Caroline Boulouis, Michał J. Sobkowiak, Kerri G. Lal, Kerri G. Lal, Kerri G. Lal, Johanna Emgård, Marcus Buggert, Tiphaine Parrot, Jean-Baptiste Gorin, Edwin Leeansyah, Edwin Leeansyah, Johan K. Sandberg   +12 more
doaj   +1 more source

Role of mucosal-associated invariant T cells dynamics in pathogenesis of Sjögren syndrome

Scientific Reports
Sjögren syndrome (SS) is an autoimmune disease characterized by chronic inflammatory infiltrates in the salivary and lacrimal glands. Mucosal-associated invariant T (MAIT) cells are a subset of innate-like T-cells, predominantly found in mucosal tissues ...
Jeanne Chauffier, Henri Berger de Gallardo, Mathieu F. Chevalier, Aïcha Kante, Marion Lambert, Xavier Cabrol, Elisa Aldersons, Stéphane Mouly, Karine Champion, Blanca Amador-Borrero, Ruxandra Burlacu, William Bigot, Homa Adle-Biassete, Rachid Kaci, Aurélie Selvanadin, Martine Cohen-Solal, Amélie Coudert, Sophie Caillat-Zucman, Damien Sène, Cloé Comarmond   +19 more
doaj   +1 more source

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.

PLoS Pathogens, 2015
Mucosa-associated invariant T (MAIT) cells represent a large innate-like evolutionarily conserved antimicrobial T-cell subset in humans. MAIT cells recognize microbial riboflavin metabolites from a range of microbes presented by MR1 molecules. MAIT cells
Edwin Leeansyah, Jenny Svärd, Joana Dias, Marcus Buggert, Jessica Nyström, Máire F Quigley, Markus Moll, Anders Sönnerborg, Piotr Nowak, Johan K Sandberg   +9 more
doaj   +1 more source

MAIT cell responses to Staphylococcus aureus and sensitivity to HlgAB toxin are modulated by activation and tissue-dependent virulence effects

mBio
Mucosa-associated invariant T (MAIT) cells are unconventional T cells with innate-like rapid antimicrobial effector functions and serve as resident sentinels at mucosal and non-mucosal barriers.
Elisa J. M. Raineri, Caroline Boulouis, Elli Mouchtaridi, Vera Nilsén, Curtis Cai, Tobias Kammann, Juliette Tabusse, Takuya Sekine, Nicole Wild, Christian Constantz, Eoghann White, Thomas R. Müller, Anne Marchalot, Sabrina Ferreira, Jyotsana Kaushal, Akhirunnesa Mily, Miriam Franklin, Elena Bonaiti, Mary-Lyn Eichhorn, John Bassett, Chris Stamper, Jeffrey Y. W. Mak, David P. Fairlie, Chris Tibbitt, Anna Norrby-Teglund, Nicole Marquardt, Jenny Mjösberg, Carl Jorns, Jenny Driving, Edwin Leeansyah, Marcus Buggert, Johan K. Sandberg   +31 more
doaj   +1 more source

Functions of mucosal associated invariant T cells in eye diseases

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells are a unique subset of T cells that recognizes metabolites derived from the vitamin B2 biosynthetic pathway. Since the identification of cognate antigens for MAIT cells, knowledge of the functions of MAIT cells
Chihiro Fukui, Satoshi Yamana, Yanqi Xue, Mariko Shirane, Hiroki Tsutsui, Kenichiro Asahara, Keiko Yoshitomi, Takako Ito, Tantri Lestari, Eiichi Hasegawa, Nobuyo Yawata, Atsunobu Takeda, Koh-Hei Sonoda, Kensuke Shibata, Kensuke Shibata, Kensuke Shibata   +15 more
doaj   +1 more source

Potential of MAIT cells to modulate asthma

Allergology International
Despite recent advances in asthma treatments, the search for novel therapies remains necessary because there are still patients with recurrent asthma exacerbations and poor responses to the existing treatments. Since group 2 innate lymphoid cells (ILC2) play a pivotal role in asthma by triggering and exacerbating type 2 inflammation, controlling ILC2s ...
Yasuo Shimizu, Chie Sugimoto, Hiroshi Wakao   +2 more
openaire   +3 more sources

Estrogen Induced Regulation of Mucosal-Associated Invariant T Cells in Asthma

Journal of Immunology Research
Asthma affects over 300 million people worldwide, with increasing rates annually. Males have higher asthma prevalence in adolescence, while females exhibit higher rates in adulthood. Reduced mucosal-associated invariant T (MAIT) cells are found in severe
Shubhanshi Trivedi, Samuel E. Aamodt, Thomas P. Huecksteadt, Elizabeth J. Myers, Grace Helen McGee, Jackson G. Cacioppo, Jeffrey Aubé, Robert Paine, Daniel T. Leung, Kristi J. Warren   +9 more
doaj   +1 more source

MAIT cells: Conserved watchers on the wall

Journal of Experimental Medicine
MAIT cells are innate-like T cells residing in barrier tissues such as the lung, skin, and intestine. Both the semi-invariant T cell receptor of MAIT cells and the restricting element MR1 are deeply conserved across mammals, indicating non-redundant functions linked to antigenic specificity.
Lilou Germain, Pablo Veloso, Olivier Lantz, François Legoux   +3 more
openaire   +3 more sources

CXCR6-positive circulating mucosal-associated invariant T cells can identify patients with non-small cell lung cancer responding to anti-PD-1 immunotherapy

Journal of Experimental & Clinical Cancer Research
Background Mucosal-associated invariant T (MAIT) cells have been reported to regulate tumor immunity. However, the immune characteristics of MAIT cells in non-small cell lung cancer (NSCLC) and their correlation with the treatment efficacy of immune ...
Jingjing Qu, Binggen Wu, Lijun Chen, Zuoshi Wen, Liangjie Fang, Jing Zheng, Qian Shen, Jianfu Heng, Jianya Zhou, Jianying Zhou   +9 more
doaj   +1 more source