Results 81 to 90 of about 10,390 (221)

Characterising MAIT cells in human mucosal cancers

, 2021
Mucosal associated invariant T cells (MAIT cells) are MR1-restricted T cells that regulate the local immune milieu with cytotoxic and cytokine responses.
Kelly, Jason
core  

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Human MAIT cells are cytotoxic.

, 2013
(A–B) Activation of purified MAIT (Vα7.2+CD161hi) cells cultured with Hela cells or Hela cells overexpressing the human MR1 protein (Hela-hMR1), in presence of increasing multiplicity of infections (MOI) of Escherichia coli (Ec).
Emmanuel Martin (95724), David Sleurs (469494), Stéphanie Bessoles (469492), Nacer-Eddine Serriari (469495), Emmanuel Treiner (266383), Claire Hivroz (221755), Mathilde Dusseaux (469491), Philippe Sansonetti (69367), Marie-Lise Gougeon (248350), Virginie Premel (266399), Maxime Coré (469493), Claire Soudais (64699), Armelle Bohineust (221753), Olivier Lantz (46680), Lionel Le Bourhis (60603)   +14 more
core   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Activation, Impaired Tumor Necrosis Factor-α Production, and Deficiency of Circulating Mucosal-Associated Invariant T Cells in Patients with Scrub Typhus. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections. However, little is known about the role of MAIT cells in Orientia tsutsugamushi infection.
Seung-Ji Kang, Hye-Mi Jin, Eun Jeong Won, Young-Nan Cho, Hyun-Ju Jung, Yong-Soo Kwon, Hae Jin Kee, Jae Kyun Ju, Jung-Chul Kim, Uh Jin Kim, Hee-Chang Jang, Sook-In Jung, Seung-Jung Kee, Yong-Wook Park   +13 more
doaj   +1 more source

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini, E. Tartaglia, F. Cristofanelli, S. Gili, F. Maggi   +4 more
wiley   +1 more source

Cigarette smoke components modulate the MR1–MAIT axis

Tobacco smoking is prevalent across the world and causes numerous diseases. Cigarette smoke (CS) compromises immunity, yet little is known of the components of CS that impact T cell function.
Haw, TJ, Hansbro, Philip M, Hansbro, Nicole G, Awad, Wael, Gillis, Caitlin M, Galvao, Izabela, Howson, Lauren J, Mak, JYW, Albers, GJ, Corbett, AJ, Fairlie, David P, Corbett, Alexandra J, Hortle, Elinor, Donovan, Chantal, Hansbro, PM, Pai, TY, Horvat, Jay C, Johansen, MD, Xu, W, Howson, LJ, Haw, Tatt Jhong, Gillis, CM, Galvao, I, Pai, Tsung-Yu, Mayall, Jemma R, Rossjohn, Jamie, Patton, T, Das, S, Awad, W, Liu, Ligong, McCluskey, James, Mak, Jeffrey Y W, Liu, L, Xu, Weijun, Patton, Timothy, Donovan, C, Lim, Xin Yi, Albers, Gesa J, Hortle, E, Brown, AC, McCluskey, J, Fairlie, DP, Brown, Alexandra C, Rossjohn, J, Johansen, Matt D, Mayall, JR, Horvat, JC, Das, Shatarupa, Hansbro, NG, Lim, XY   +49 more
core   +1 more source

Landscape weed control varies by preemergence herbicide, formulation, and geography

Agrosystems, Geosciences &Environment, Volume 9, Issue 2, June 2026.
Abstract Mulch, mechanical removal, and herbicides are the most common weed control practices employed in landscapes. Previous research demonstrated preemergence herbicide efficacy in nurseries, but research in landscapes with and without mulching is limited.
Brandon C. McNally, Zane Raudenbush, Manuel Nassar, S. Christopher Marble, Kyle M. Daniel, Carolyn Anderson, Ashley Kloes, Aaron J. Patton   +7 more
wiley   +1 more source

High pre-transplant Mucosal Associated Invariant T Cell (MAIT) count predicts favorable course of myeloid aplasia

Aims. Mucosal Associated Invariant T (MAIT) cells are unconventional T cells with anti-infective potential. MAIT cells detect and fight against microbes on mucosal surfaces and in peripheral tissues.
Jan Novak, Jitka Smetanova Brozova, Tomas Karel, Barbora Bacova, Ivana Karlova Zubata   +4 more
core   +1 more source

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1231-1244, June 2026.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source