Results 101 to 110 of about 10,390 (221)

Functions of mucosal associated invariant T cells in eye diseases

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells are a unique subset of T cells that recognizes metabolites derived from the vitamin B2 biosynthetic pathway. Since the identification of cognate antigens for MAIT cells, knowledge of the functions of MAIT cells
Chihiro Fukui, Satoshi Yamana, Yanqi Xue, Mariko Shirane, Hiroki Tsutsui, Kenichiro Asahara, Keiko Yoshitomi, Takako Ito, Tantri Lestari, Eiichi Hasegawa, Nobuyo Yawata, Atsunobu Takeda, Koh-Hei Sonoda, Kensuke Shibata, Kensuke Shibata, Kensuke Shibata   +15 more
doaj   +1 more source

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

Nature Communications, 2017
MAIT cells are activated by MR1 restricted antigens derived from riboflavin biosynthesis. Here the authors characterize MAIT cell antigenicity and synthesize a water stable antigen that activates human MAIT cellsin vitro and mouse MAIT cells in vivo.
Jeffrey Y. W. Mak, Weijun Xu, Robert C. Reid, Alexandra J. Corbett, Bronwyn S. Meehan, Huimeng Wang, Zhenjun Chen, Jamie Rossjohn, James McCluskey, Ligong Liu, David P. Fairlie   +10 more
doaj   +1 more source

Mice Generated with Induced Pluripotent Stem Cells Derived from Mucosal-Associated Invariant T Cells

Biomedicines
The function of mucosal-associated invariant T (MAIT) cells, a burgeoning member of innate-like T cells abundant in humans and implicated in many diseases, remains obscure.
Chie Sugimoto, Hiroyoshi Fujita, Hiroshi Wakao   +2 more
doaj   +1 more source

Innate-like T cell subset commitment in the murine thymus is independent of TCR characteristics and occurs during proliferation

International audienceHow T-cell receptor (TCR) characteristics determine subset commitment during T-cell development is still unclear. Here, we addressed this question for innate-like T cells, mucosal-associated invariant T (MAIT) cells, and invariant ...
Perrin, Laetitia, Legoux, Francois, Aleksandra, Walczak, Mutala, Linda, Bilonda, Darbois, Aurelie, Mora, Thierry, Lantz, Olivier, K. Karnaukhov, Vadim, Le Gac, Anne‐laure   +8 more
core   +1 more source

Characterization of human Mucosal-associated Invariant T (MAIT) cells

, 2019
Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells restricted by the major histocompatibility complex (MHC) class I–like molecule MHC-related protein 1 (MR1).
Fairlie, David P., Godfrey, DI, Chen, Z, Pellicci, DG, Shihan Li, Gherardin, Nicholas A., McCluskey, James, Godfrey, Dale I., Kjer-Nielsen, Lars, Gherardin, NA, Nicholas A. Gherardin, Meehan, BS, Dale I. Godfrey, Corbett, AJ, Kedzierska, Katherine, Chen, Zhenjun, Bronwyn S. Meehan, McCluskey, J, Lars Kjer‐Nielsen, Eckle, Sidonia B. G., Liyen Loh, Fairlie, DP, Sidonia B. G. Eckle, Alexandra J. Corbett, Souter, Michael N.T., Rossjohn, J, Jamie Rossjohn, Eckle, SBG, Corbett, Alexandra J., Zhenjun Chen, Loh, Liyen, Loh, L, Souter, MNT, Katherine Kedzierska, Li, Shihan, Meehan, Bronwyn S., Rossjohn, Jamie, Kjer-Nielsen, L, Daniel G. Pellicci, Michael N.T. Souter, James McCluskey, Pellicci, Daniel G., David P. Fairlie, Li, S, Kedzierska, K   +44 more
core   +1 more source

Increased pathogenicity and pro-inflammatory capabilities of mucosal-associated invariant T cells involved in Oral Lichen Planus

BMC Oral Health
Background Mucosal-associated invariant T (MAIT) cells assume pivotal roles in numerous autoimmune inflammatory maladies. However, scant knowledge exists regarding their involvement in the pathological progression of oral lichen planus (OLP).
Siting Chen, Xiaoli Wu, Yinshen Yang, Xiaoheng Xu, Xiaoqin Xiong, Wenxia Meng   +5 more
doaj   +1 more source

DOE contractor vulnerability analysis: DPA or MAIT [PDF]

, 1980
Two vulnerability analysis techniques, Diversion Path Analysis (DPA) and Matrix Analysis of the Insider Threat (MAIT), were applied by EG and G Idaho, Inc. Safeguards and Security to the same item accountable SNM storage area at INEL.
Nichols, D.H., Six, D.E.
core  

MAIT cells in T1D patients

, 2019
Le diabète de type 1 (DT1) est une maladie auto-immune caractérisée par l'implication du système immunitaire adaptatif mais également inné. Des altérations de l'homéostasie intestinale sont également décrites. Les cellules MAIT appartiennent à la famille
Nel, Isabelle
core  

The antimicrobial role of human MAIT cells

, 2021
MAIT cells are unconventional T cells that have characteristics of both innate and adaptive immunity. Their fast mobilization and wide distribution in tissues make them part of the first line of defense against infection.
Caroline Boulouis (18658708)
core  

Role of mucosal-associated invariant T cells dynamics in pathogenesis of Sjögren syndrome

Scientific Reports
Sjögren syndrome (SS) is an autoimmune disease characterized by chronic inflammatory infiltrates in the salivary and lacrimal glands. Mucosal-associated invariant T (MAIT) cells are a subset of innate-like T-cells, predominantly found in mucosal tissues ...
Jeanne Chauffier, Henri Berger de Gallardo, Mathieu F. Chevalier, Aïcha Kante, Marion Lambert, Xavier Cabrol, Elisa Aldersons, Stéphane Mouly, Karine Champion, Blanca Amador-Borrero, Ruxandra Burlacu, William Bigot, Homa Adle-Biassete, Rachid Kaci, Aurélie Selvanadin, Martine Cohen-Solal, Amélie Coudert, Sophie Caillat-Zucman, Damien Sène, Cloé Comarmond   +19 more
doaj   +1 more source