Results 1 to 10 of about 8,261 (205)

MAIT cells and the microbiome. [PDF]

Front Immunol, 2023
Mucosal associated invariant T (MAIT) cells are innate-like T lymphocytes, strikingly enriched at mucosal surfaces and characterized by a semi-invariant αβ T cell receptor (TCR) recognizing microbial derived intermediates of riboflavin synthesis ...
Jabeen MF, Hinks TSC.
europepmc   +7 more sources

MAIT Cells in Health and Disease

Annual Review of Immunology, 2020
Mucosal-associated invariant T (MAIT) cells are a newly described subset of T cells that are found in the blood and are enriched in many tissues, particularly in the liver. MAIT cells express a semi-invariant T cell receptor restricted by the MHC class I-
Nicholas M Provine, Paul Klenerman
exaly   +6 more sources

MAIT cells: Conserved watchers on the wall. [PDF]

J Exp Med
International audienceMAIT cells are innate-like T cells residing in barrier tissues such as the lung, skin, and intestine. Both the semi-invariant T cell receptor of MAIT cells and the restricting element MR1 are deeply conserved across mammals ...
Germain L, Veloso P, Lantz O, Legoux F.
europepmc   +5 more sources

In patients with primary Sjögren’s syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells

Frontiers in Immunology, 2022
IntroductionMucosal-associated invariant T (MAIT) cells might play a role in B cell hyperactivity and local inflammation in primary Sjögren’s syndrome (pSS), just like previously studied mucosa-associated CCR9+ and CXCR5+ T helper cells.
Anneline C. Hinrichs, Anneline C. Hinrichs, Aike A. Kruize, Helen L. Leavis, Joel A. G. van Roon, Joel A. G. van Roon   +5 more
doaj   +3 more sources

MAIT cells protect against sterile lung injury. [PDF]

Cell Rep
Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, have been recently linked to tissue protection and repair. Their role, especially in sterile lung injury, is unknown.
Zhang X, Li S, Lason W, Greco M, Klenerman P, Hinks TSC.   +5 more
europepmc   +5 more sources

MAIT Cells with High PFN1 Expression Mediate Immune Activation and Metabolic Reprogramming in Psoriasis. [PDF]

Clin Cosmet Investig Dermatol
Man-Ning Wu,1– 3 Yue-Min Zou,1– 3 Xiang-Nan Zhou,2,3 Sangwon Hong,1– 3 Lei Wang,2,3 Yan-Ping Bai2,3 1Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of China; 2Department of Dermatology, China-Japan Friendship Hospital ...
Wu MN, Zou YM, Zhou XN, Hong S, Wang L, Bai YP.   +5 more
europepmc   +2 more sources

Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing

Immunity, 2023
International audienceTissue repair processes maintain proper organ function following mechanical or infection-related damage. In addition to antibacterial properties, mucosal associated invariant T (MAIT) cells express a tissue repair transcriptomic ...
Anastasia Du Halgouet, Virginie Premel
exaly   +2 more sources

Human liver‐derived MAIT cells differ from blood MAIT cells in their metabolism and response to TCR‐independent activation

European Journal of Immunology, 2021
Mucosal associated invariant T (MAIT) cells are anti-microbial innate-like T cells that are abundant in blood and liver. MAIT cells express a semi-invariant T-cell receptor (TCR) that recognizes a pyrimidine ligand, derived from microbial riboflavin ...
Rajesh Lamichhane, Thomas W R Harrop, Peter K Dearden   +2 more
exaly   +2 more sources

MAIT cells detect and efficiently lyse bacterially-infected epithelial cells.

PLoS Pathogens, 2013
Mucosal associated invariant T cells (MAIT) are innate T lymphocytes that detect a large variety of bacteria and yeasts. This recognition depends on the detection of microbial compounds presented by the evolutionarily conserved major-histocompatibility ...
Lionel Le Bourhis, Mathilde Dusseaux, Armelle Bohineust, Stéphanie Bessoles, Emmanuel Martin, Virginie Premel, Maxime Coré, David Sleurs, Nacer-Eddine Serriari, Emmanuel Treiner, Claire Hivroz, Philippe Sansonetti, Marie-Lise Gougeon, Claire Soudais, Olivier Lantz   +14 more
doaj   +2 more sources

MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis. [PDF]

Sci Immunol
International audienceIntestinal inflammation shifts microbiota composition and metabolism. How the host monitors and responds to such changes remains unclear.
El Morr Y, Fürstenheim M, Mestdagh M, Franciszkiewicz K, Salou M, Morvan C, Dupré T, Vorobev A, Jneid B, Premel V, Darbois A, Perrin L, Mondot S, Colombeau L, Bugaut H, du Halgouet A, Richon S, Procopio E, Maurin M, Philippe C, Rodriguez R, Lantz O, Legoux F.   +22 more
europepmc   +2 more sources