Results 1 to 10 of about 7,034 (118)

MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection

Frontiers in Immunology, 2021
Mucosal associated invariant T (MAIT) cells are a class of innate-like T cells that utilize a semi-invariant αβ T cell receptor to recognize small molecule ligands produced by bacteria and fungi.
Sharon Khuzwayo, Sharon Khuzwayo, Maphe Mthembu, Maphe Mthembu, Erin W. Meermeier, Sanjay M. Prakadan, Sanjay M. Prakadan, Sanjay M. Prakadan, Samuel W. Kazer, Samuel W. Kazer, Samuel W. Kazer, Thierry Bassett, Kennedy Nyamande, Dilshaad Fakey Khan, Priya Maharaj, Mohammed Mitha, Moosa Suleman, Moosa Suleman, Zoey Mhlane, Dirhona Ramjit, Farina Karim, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, David M. Lewinsohn, David M. Lewinsohn, David M. Lewinsohn, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Emily B. Wong, Emily B. Wong, Emily B. Wong, Emily B. Wong   +36 more
doaj   +1 more source

In patients with primary Sjögren’s syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells

Frontiers in Immunology, 2022
IntroductionMucosal-associated invariant T (MAIT) cells might play a role in B cell hyperactivity and local inflammation in primary Sjögren’s syndrome (pSS), just like previously studied mucosa-associated CCR9+ and CXCR5+ T helper cells.
Anneline C. Hinrichs, Anneline C. Hinrichs, Aike A. Kruize, Helen L. Leavis, Joel A. G. van Roon, Joel A. G. van Roon   +5 more
doaj   +1 more source

Effects of interleukin-23 on the activation of mucosal-associated invariant T cells from oral lichen planus

Journal of International Medical Research, 2023
Objective Oral lichen planus (OLP) is a T cell-mediated inflammatory condition in the oral cavity. Mucosal-associated invariant T (MAIT) cells are gaining more relevance in immune diseases because they can be activated by cytokines without T cell ...
Fang Wang, Xiu-Li Zhang, Jing-Ya Yang, Gang Zhou   +3 more
doaj   +1 more source

Involvement of impaired CD8+ mucosal-associated invariant T cells and myeloid-derived suppressor cells in polycystic ovary syndrome

Reproductive Biology and Endocrinology, 2021
Background Immune dysfunction is one of the mechanisms to promote polycystic ovary syndrome (PCOS). Various immune cells have been reported to be involved in the development of PCOS.
Mengting Zhu, Yuping Xu, Caihua Li, Zhimin Lu, Kaihuan Bi, Kangxia Wang, Peipei Guo, Huanhuan Jiang, Yunxia Cao   +8 more
doaj   +1 more source

Varicella Zoster Virus infects mucosal associated Invariant T cells

Frontiers in Immunology, 2023
IntroductionMucosal Associated Invariant T (MAIT) cells are innate-like T cells that respond to conserved pathogen-derived vitamin B metabolites presented by the MHC class I related-1 molecule (MR1) antigen presentation pathway.
Shivam K. Purohit, Alexandra J. Corbett, Barry Slobedman, Allison Abendroth   +3 more
doaj   +1 more source

Mucosal-associated invariant T cells repress group 2 innate lymphoid cells in Alternaria alternata-induced model of allergic airway inflammation

Frontiers in Immunology, 2022
Mucosal-associated invariant T (MAIT) cells, a blossoming member of the innate-like T cells, play a pivotal role in host defense through engaging the mucosal immunity.
Yasuo Shimizu, Yasuo Shimizu, Yukiko Horigane-Konakai, Yoshii Ishii, Chie Sugimoto, Hiroshi Wakao   +5 more
doaj   +1 more source

Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19

Frontiers in Immunology, 2021
BackgroundMucosal-associated invariant T (MAIT) cells are considered to participate of the host immune response against acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, single-cell transcriptomic profiling of MAIT ...
Jijing Shi, Jijing Shi, Jianglin Zhou, Xiaochang Zhang, Wei Hu, Wei Hu, Jin-Fang Zhao, Shengqi Wang, Fu-Sheng Wang, Fu-Sheng Wang, Ji-Yuan Zhang   +10 more
doaj   +1 more source

Frequencies of Circulating MAIT Cells Are Diminished in Chronic HCV, HIV and HCV/HIV Co-Infection and Do Not Recover during Therapy. [PDF]

PLoS ONE, 2016
Mucosal-associated invariant T (MAIT) cells comprise a subpopulation of T cells that can be activated by bacterial products and cytokines to produce IFN-γ. Since little is known on MAIT cells during HCV infection, we compared their phenotype and function
Michelle Spaan, Sebastiaan J Hullegie, Boris J B Beudeker, Kim Kreefft, Gertine W van Oord, Zwier M A Groothuismink, Marjolein van Tilborg, Bart Rijnders, Robert J de Knegt, Mark A A Claassen, Andre Boonstra   +10 more
doaj   +1 more source

Low mucosal-associated invariant T-cell number in peripheral blood of patients with immune thrombocytopenia and their response to prednisolone. [PDF]

PLoS ONE, 2018
Mucosal-associated invariant T (MAIT) cells help protect against certain infections and are related to some autoimmune diseases. Immune thrombocytopenia (ITP) is a relatively rare hematological autoimmune disease associated with low platelet count.
Takaaki Maekawa, Yukiko Osawa, Yosuke Okada, Noriaki Tachi, Masahiro Teramoto, Toshikuni Kawamura, Toshikatsu Horiuchi, Shoichiro Kato, Ayako Kobayashi, Shinichi Kobayashi, Ken Sato, Fumihiko Kimura   +11 more
doaj   +1 more source

Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections

Frontiers in Immunology, 2021
Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells that utilize a semi-invariant T cell receptor (TCR) α chain and are restricted by the highly conserved antigen presenting molecule MR1.
Matthew D. Edmans, Matthew D. Edmans, Timothy K. Connelley, Siddharth Jayaraman, Christina Vrettou, Martin Vordermeier, Martin Vordermeier, Jeffrey Y. W. Mak, Jeffrey Y. W. Mak, Ligong Liu, Ligong Liu, Ligong Liu, David P. Fairlie, David P. Fairlie, David P. Fairlie, Emmanuel Atangana Maze, Tiphany Chrun, Paul Klenerman, Sidonia B. G. Eckle, Elma Tchilian, Lindert Benedictus, Lindert Benedictus   +21 more
doaj   +1 more source