Results 1 to 10 of about 12,460 (159)

Mucosal Associated Invariant T cells in the human gastric mucosa and blood: Role in Helicobacter pylori infection [PDF]

Frontiers in Immunology, 2015
Mucosal-associated invariant T (MAIT) cells represent a class of antimicrobial innate-like T cells that have been characterized in human blood, liver, lungs and intestine.
Jayaum S Booth, Jayaum S Booth, Rosangela eSalerno-Goncalves, Rosangela eSalerno-Goncalves, Thomas G Blanchard, Seema A. Patil, Seema A. Patil, Howard A. Kader, Anca M. Safta, Lindsay M. Morningstar, Steven J. Czinn, Bruce D. Greenwald, Bruce D. Greenwald, Marcelo B. Sztein, Marcelo B. Sztein, Marcelo B. Sztein   +15 more
doaj   +2 more sources

Frequencies of Circulating MAIT Cells Are Diminished in Chronic HCV, HIV and HCV/HIV Co-Infection and Do Not Recover during Therapy. [PDF]

PLoS ONE, 2016
Mucosal-associated invariant T (MAIT) cells comprise a subpopulation of T cells that can be activated by bacterial products and cytokines to produce IFN-γ. Since little is known on MAIT cells during HCV infection, we compared their phenotype and function
Michelle Spaan, Sebastiaan J Hullegie, Boris J B Beudeker, Kim Kreefft, Gertine W van Oord, Zwier M A Groothuismink, Marjolein van Tilborg, Bart Rijnders, Robert J de Knegt, Mark A A Claassen, Andre Boonstra   +10 more
doaj   +4 more sources

In patients with primary Sjögren’s syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells

Frontiers in Immunology, 2022
IntroductionMucosal-associated invariant T (MAIT) cells might play a role in B cell hyperactivity and local inflammation in primary Sjögren’s syndrome (pSS), just like previously studied mucosa-associated CCR9+ and CXCR5+ T helper cells.
Anneline C. Hinrichs, Anneline C. Hinrichs, Aike A. Kruize, Helen L. Leavis, Joel A. G. van Roon, Joel A. G. van Roon   +5 more
doaj   +3 more sources

Human MAIT cells undergo clonal selection and expansion during thymic maturation and aging [PDF]

Experimental and Molecular Medicine
Mucosal-associated invariant T (MAIT) cells harbor conserved T cell receptors (TCRs) recognizing riboflavin metabolites, yet exhibit substantial diversity similar to conventional memory T cells.
Myeong-seok Lee, Suyeong Park, Jung-Hwan Choi, Seon Yong Bae, Han Suk Ryu, Min-Sung Kim, Jae Gun Kwak, You Jeong Lee   +7 more
doaj   +2 more sources

MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection

Frontiers in Immunology, 2021
Mucosal associated invariant T (MAIT) cells are a class of innate-like T cells that utilize a semi-invariant αβ T cell receptor to recognize small molecule ligands produced by bacteria and fungi.
Sharon Khuzwayo, Sharon Khuzwayo, Maphe Mthembu, Maphe Mthembu, Erin W. Meermeier, Sanjay M. Prakadan, Sanjay M. Prakadan, Sanjay M. Prakadan, Samuel W. Kazer, Samuel W. Kazer, Samuel W. Kazer, Thierry Bassett, Kennedy Nyamande, Dilshaad Fakey Khan, Priya Maharaj, Mohammed Mitha, Moosa Suleman, Moosa Suleman, Zoey Mhlane, Dirhona Ramjit, Farina Karim, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, David M. Lewinsohn, David M. Lewinsohn, David M. Lewinsohn, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Emily B. Wong, Emily B. Wong, Emily B. Wong, Emily B. Wong   +36 more
doaj   +1 more source

Effects of interleukin-23 on the activation of mucosal-associated invariant T cells from oral lichen planus

Journal of International Medical Research, 2023
Objective Oral lichen planus (OLP) is a T cell-mediated inflammatory condition in the oral cavity. Mucosal-associated invariant T (MAIT) cells are gaining more relevance in immune diseases because they can be activated by cytokines without T cell ...
Fang Wang, Xiu-Li Zhang, Jing-Ya Yang, Gang Zhou   +3 more
doaj   +1 more source

Involvement of impaired CD8+ mucosal-associated invariant T cells and myeloid-derived suppressor cells in polycystic ovary syndrome

Reproductive Biology and Endocrinology, 2021
Background Immune dysfunction is one of the mechanisms to promote polycystic ovary syndrome (PCOS). Various immune cells have been reported to be involved in the development of PCOS.
Mengting Zhu, Yuping Xu, Caihua Li, Zhimin Lu, Kaihuan Bi, Kangxia Wang, Peipei Guo, Huanhuan Jiang, Yunxia Cao   +8 more
doaj   +1 more source

Mucosal-associated invariant T cells repress group 2 innate lymphoid cells in Alternaria alternata-induced model of allergic airway inflammation

Frontiers in Immunology, 2022
Mucosal-associated invariant T (MAIT) cells, a blossoming member of the innate-like T cells, play a pivotal role in host defense through engaging the mucosal immunity.
Yasuo Shimizu, Yasuo Shimizu, Yukiko Horigane-Konakai, Yoshii Ishii, Chie Sugimoto, Hiroshi Wakao   +5 more
doaj   +1 more source

Varicella Zoster Virus infects mucosal associated Invariant T cells

Frontiers in Immunology, 2023
IntroductionMucosal Associated Invariant T (MAIT) cells are innate-like T cells that respond to conserved pathogen-derived vitamin B metabolites presented by the MHC class I related-1 molecule (MR1) antigen presentation pathway.
Shivam K. Purohit, Alexandra J. Corbett, Barry Slobedman, Allison Abendroth   +3 more
doaj   +1 more source

MAIT cells come to the rescue in cancer immunotherapy? [PDF]

, 2020
Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells.
Elewaut, Dirk, Venken, Koen, Łukasik, Zuzanna   +2 more
core   +2 more sources