Results 21 to 30 of about 8,261 (205)

MAIT cells as attractive vaccine targets

FEBS Letters, 2019
Mucosal-associated invariant T (MAIT) cells are a subset of T-cells that perform innate-like immunity functions upon recognition of small molecule vitamin B metabolites presented by the MHC, class I-related protein-1 (MR1).
Peter H. Seeberger, Downey, M., A. Michael Downey, Paulina Kapłonek, Kaplonek, P., Seeberger, P.   +5 more
core   +4 more sources

MAIT Cells in Liver Disease. [PDF]

Cells
Mucosal-associated invariant T (MAIT) cells are abundant innate-like T lymphocytes in the human liver which can provide antimicrobial defense, amplify inflammatory processes and mediate tissue repair and fibrosis depending on microenvironmental cues.
Azad AI, Gutierrez F, Gores GJ.
europepmc   +4 more sources

Nasal mRNA Nanovaccine with Key Activators of Dendritic and MAIT Cells for Effective Against Lung Tumor Metastasis in Mice Model. [PDF]

Int J Nanomedicine
Ang Li,1,* Xushan Cai,2,* Dong Li,1,* Yimin Yu,1 Chengyu Liu,1 Jie Shen,1 Jiaqi You,3 Jianou Qiao,3 Feng Wang4 1Department of Laboratory Medicine, Shanghai Tongji Hospital, School of Medicine, School of Life Science and Technology, Tongji ...
Li A, Cai X, Li D, Yu Y, Liu C, Shen J, You J, Qiao J, Wang F.   +8 more
europepmc   +2 more sources

MAIT Cell Activation and Functions [PDF]

Frontiers in Immunology, 2020
Mucosal associated invariant T (MAIT) cells are striking in their abundance and their strict conservation across 150 million years of mammalian evolution, implying they must fulfill critical immunological function(s). MAIT cells are defined by their expression of a semi-invariant αβ TCR which recognizes biosynthetic derivatives of riboflavin synthesis ...
Timothy S. C. Hinks, Xia-Wei Zhang, Xia-Wei Zhang   +2 more
openaire   +4 more sources

Editorial: MAIT cells come of age. [PDF]

Front Immunol, 2023
Corbett AJ, Ussher JE, Hinks TSC.
europepmc   +5 more sources

MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection

Frontiers in Immunology, 2021
Mucosal associated invariant T (MAIT) cells are a class of innate-like T cells that utilize a semi-invariant αβ T cell receptor to recognize small molecule ligands produced by bacteria and fungi.
Sharon Khuzwayo, Sharon Khuzwayo, Maphe Mthembu, Maphe Mthembu, Erin W. Meermeier, Sanjay M. Prakadan, Sanjay M. Prakadan, Sanjay M. Prakadan, Samuel W. Kazer, Samuel W. Kazer, Samuel W. Kazer, Thierry Bassett, Kennedy Nyamande, Dilshaad Fakey Khan, Priya Maharaj, Mohammed Mitha, Moosa Suleman, Moosa Suleman, Zoey Mhlane, Dirhona Ramjit, Farina Karim, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, David M. Lewinsohn, David M. Lewinsohn, David M. Lewinsohn, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Emily B. Wong, Emily B. Wong, Emily B. Wong, Emily B. Wong   +36 more
doaj   +1 more source

Effects of interleukin-23 on the activation of mucosal-associated invariant T cells from oral lichen planus

Journal of International Medical Research, 2023
Objective Oral lichen planus (OLP) is a T cell-mediated inflammatory condition in the oral cavity. Mucosal-associated invariant T (MAIT) cells are gaining more relevance in immune diseases because they can be activated by cytokines without T cell ...
Fang Wang, Xiu-Li Zhang, Jing-Ya Yang, Gang Zhou   +3 more
doaj   +1 more source

Involvement of impaired CD8+ mucosal-associated invariant T cells and myeloid-derived suppressor cells in polycystic ovary syndrome

Reproductive Biology and Endocrinology, 2021
Background Immune dysfunction is one of the mechanisms to promote polycystic ovary syndrome (PCOS). Various immune cells have been reported to be involved in the development of PCOS.
Mengting Zhu, Yuping Xu, Caihua Li, Zhimin Lu, Kaihuan Bi, Kangxia Wang, Peipei Guo, Huanhuan Jiang, Yunxia Cao   +8 more
doaj   +1 more source

Mucosal-associated invariant T cells repress group 2 innate lymphoid cells in Alternaria alternata-induced model of allergic airway inflammation

Frontiers in Immunology, 2022
Mucosal-associated invariant T (MAIT) cells, a blossoming member of the innate-like T cells, play a pivotal role in host defense through engaging the mucosal immunity.
Yasuo Shimizu, Yasuo Shimizu, Yukiko Horigane-Konakai, Yoshii Ishii, Chie Sugimoto, Hiroshi Wakao   +5 more
doaj   +1 more source

Varicella Zoster Virus infects mucosal associated Invariant T cells

Frontiers in Immunology, 2023
IntroductionMucosal Associated Invariant T (MAIT) cells are innate-like T cells that respond to conserved pathogen-derived vitamin B metabolites presented by the MHC class I related-1 molecule (MR1) antigen presentation pathway.
Shivam K. Purohit, Alexandra J. Corbett, Barry Slobedman, Allison Abendroth   +3 more
doaj   +1 more source