Results 21 to 30 of about 12,530 (222)

Mucosal-Associated Invariant T Cells Display a Poor Reconstitution and Altered Phenotype after Allogeneic Hematopoietic Stem Cell Transplantation

Frontiers in Immunology, 2017
Mucosal-associated invariant T (MAIT) cells are innate-like T cells which are important in the defense against certain bacteria and yeast. The reconstitution of MAIT cells after allogeneic hematopoietic stem cell transplantation (HSCT) is not known.
Martin Solders, Tom Erkers, Laia Gorchs, Thomas Poiret, Mats Remberger, Mats Remberger, Isabelle Magalhaes, Helen Kaipe, Helen Kaipe   +8 more
doaj   +1 more source

MAIT cells boost adenovirus-induced CD8+ T cells [PDF]

Nature Reviews Immunology, 2021
MAIT cells found to have central role in the induction of CD8(+) T cell immunity in response to vaccination with ChAdOx1 adenoviral vectors.
openaire   +2 more sources

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers [PDF]

, 2015
Studies on the biology of mucosal-associated invariant T cells (MAIT cells) in mice have been hampered by a lack of specific reagents. Using MR1-antigen (Ag) tetramers that specifically bind to the MR1-restricted MAIT T cell receptors (TCRs), we ...
Chen, Zhenjun, Clanchy, Rhiannon, Eckle, Sidonia B. G., Enders, Anselm, Fairlie, David P., Godfrey, Dale I., Goodnow, Chris C., Koay, Hui Fern, Liu, Ligong, McCluskey, James, Meehan, Bronwyn, Pellicci, Daniel G., Rahimpour, Azad, Rossjohn, Jamie, Uldrich, Adam P., Whittle, Belinda   +15 more
core   +3 more sources

Peripheral and intestinal mucosal-associated invariant T cells in premature infants with necrotizing enterocolitis

Frontiers in Pharmacology, 2022
Background: Necrotizing enterocolitis (NEC) is a potentially fatal inflammatory gastrointestinal disease in preterm infants with unknown pathogenesis. Mucosal-associated invariant T (MAIT) cells primarily accumulate at sites where exposure to microbes is
Jiayi Tian, Chaoying Yan, Yanfang Jiang, Haohan Zhou, Liyuan Li, Jingjing Shen, Jian Wang, Hongyu Sun, Guang Yang, Wei Sun   +9 more
doaj   +1 more source

Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection [PDF]

, 2012
Mucosa-associated invariant T (MAIT) cells are a unique population of αβ T cells in mammals that reside preferentially in mucosal tissues and express an invariant Vα paired with limited Vβ T-cell receptor (TCR) chains.
Andersen, Annibali, Azra Blazevic, Berrington, Berzins, Billerbeck, Borg, Brennan, Brigl, Brigl, Chiba, Cho, Christopher S. Eickhoff, Chua, Chua, Cogen, Cohen, Cooper, Cooper, Cowley, Cowley, Croxford, Cua, Curtis, D'Souza, D'Souza, Daniel F. Hoft, Dusseaux, Elkins, Feng, Flesch, Flynn, Flynn, Gansert, Georgel, Gold, Gold, Goldfinch, Gopal, Green, Hansen, Huang, Huang, Huang, J. L. Flynn, Jovanovic, Junqueira-Kipnis, Kariyone, Kawachi, Khader, Khader, Kinjo, Ladel, Le Bourhis, Lin, Lockhart, Lozes, MacMicking, Martin, Miley, Misko, Miyazaki, Nagarajan, Parker, Parra, Pollock, Qian, Riegert, Rodgers, Sada-Ovalle, Schoenborn, Shimamura, Skold, Sousa, Steven M. Truscott, Ted H. Hansen, Tilloy, Treiner, Treiner, Tupin, Tyznik, Urdahl, Wei-Jen Chua, Worku, Yamaguchi, Yamaguchi, Zhang   +86 more
core   +2 more sources

MAIT cells in metabolic diseases

Molecular Metabolism, 2019
Metabolic diseases represent a wide category of alterations affecting metabolism. These pathologies are notably marked by inflammation that implicates the immune system. Mucosal Associated Invariant (MAI)T cells are immune cells expressing a semi-invariant TCR able to recognize bacterial and fungal vitamin B metabolites.
Bertrand, Léo, Lehuen, Agnès
openaire   +4 more sources

Human MAIT Cell Activation In Vitro [PDF]

, 2019
Mucosal-associated invariant T (MAIT) cells are an abundant innate-like T cell subset in humans, enriched in mucosal tissues and the liver. MAIT cells express a semi-invariant T cell receptor (TCR) and recognize microbial-derived riboflavin metabolites presented on the MHC Class I-like molecule MR1. In addition to activation via the TCR, MAIT cells can
Hagel, JP, Garner, LC, Bilton, M, Mehta, H, Leng, T, Hackstein, C-P, Phalora, P, Amini, A, Akther, HD, Provine, NM, Edmans, M, Willberg, CB, Klenerman, P   +12 more
openaire   +3 more sources

MAIT cells: Conserved watchers on the wall. [PDF]

J Exp Med
MAIT cells are innate-like T cells residing in barrier tissues such as the lung, skin, and intestine. Both the semi-invariant T cell receptor of MAIT cells and the restricting element MR1 are deeply conserved across mammals, indicating non-redundant functions linked to antigenic specificity.
Germain L, Veloso P, Lantz O, Legoux F.
europepmc   +4 more sources

Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes [PDF]

, 2017
Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction of pancreatic β-cells by the immune system that involves innate and adaptive immune cells.
Battaglia, Manuela, Beaudoin, Lucie, Beltrand, Jacques, Cagninacci, Lucie, Corbett, Alexandra, Da silva, Jennifer, Diedisheim, Marc, Kiaf, Badr, Lantz, Olivier, Lehuen, Agnès, McCluskey, James, Nel, Isabelle, Oshima, Masaya, Polak, Michel, Rossjohn, Jamie, Rouxel, Ophélie, Salou, Marion, Scharfmann, Raphael, Tard, Céline   +18 more
core   +4 more sources

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18–dependent activation [PDF]

, 2016
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes known to elicit potent immunity to a broad range of bacteria, mainly via the rapid production of inflammatory cytokines. Whether MAIT cells contribute to antiviral immunity is less
Corbett, Alexandra J., Crowe, Jane, Doherty, Peter C., Fairlie, David P., Jegaskanda, Sinthujan, Kedzierska, Katherine, Koutsakos, Marios, Liu, Ligong, Loh, Liyen, McCluskey, James, Rossjohn, Jamie, Sant, Sneha, Wang, Zhongfang, Xu, Jianqing   +13 more
core   +2 more sources