Results 11 to 20 of about 8,261 (205)

MAIT cells and viruses [PDF]

Immunology and Cell Biology, 2018
Mucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that specifically targets microbially-derived metabolites. Functionally they respond to bacteria and yeasts, which possess the riboflavin pathway, essential for production of ...
James E Ussher, Christian B Willberg, Paul Klenerman   +2 more
exaly   +5 more sources

MAIT cells in metabolic diseases

Molecular Metabolism, 2018
International audienceMetabolic diseases represent a wide category of alterations affecting metabolism. These pathologies are notably marked by inflammation that implicates the immune system.
Bertrand, Léo, Lehuen, Agnès
core   +5 more sources

MAIT cells in the liver environment

, 2021
MAIT cells are an important innate T cell population capable of recognising riboflavin-derived ligands presented by the evolutionary conserved MR1 molecule.
Mehta, Hema
core   +2 more sources

Stepwise development of MAIT cells in mouse and human. [PDF]

PLoS Biology, 2009
Mucosal-associated invariant T (MAIT) cells display two evolutionarily conserved features: an invariant T cell receptor (TCR)alpha (iTCRalpha) chain and restriction by the nonpolymorphic class Ib major histocompatibility complex (MHC) molecule, MHC ...
Emmanuel Martin, Emmanuel Treiner, Livine Duban, Lucia Guerri, Hélène Laude, Cécile Toly, Virginie Premel, Anne Devys, Ivan C Moura, Florence Tilloy, Stéphane Cherif, Gabriella Vera, Sylvain Latour, Claire Soudais, Olivier Lantz   +14 more
doaj   +3 more sources

Human MAIT cells undergo clonal selection and expansion during thymic maturation and aging [PDF]

Experimental and Molecular Medicine
Mucosal-associated invariant T (MAIT) cells harbor conserved T cell receptors (TCRs) recognizing riboflavin metabolites, yet exhibit substantial diversity similar to conventional memory T cells.
Myeong-seok Lee, Suyeong Park, Jung-Hwan Choi, Seon Yong Bae, Han Suk Ryu, Min-Sung Kim, Jae Gun Kwak, You Jeong Lee   +7 more
doaj   +2 more sources

MAIT cells in liver inflammation and fibrosis

Seminars in Immunopathology, 2022
Mucosal-associated invariant T cells or MAIT cells are an abundant cell type in humans and especially so in the liver. MAIT cells are a subset of T lymphocytes that sit at a bridge between innate and adaptive immunity, so-called innate-like or ...
Klenerman, Paul, Filipowicz Sinnreich, Magdalena, Lett, Martin Joseph, Mehta, Hema   +3 more
core   +3 more sources

A conserved transcriptional program for MAIT cells across mammalian evolution. [PDF]

J Exp Med
International audienceMucosal-associated invariant T (MAIT) cells harbor evolutionarily conserved TCRs, suggesting important functions. As human and mouse MAIT functional programs appear distinct, the evolutionarily conserved MAIT functional features ...
Bugaut H, El Morr Y, Mestdagh M, Darbois A, Paiva RA, Salou M, Perrin L, Fürstenheim M, du Halgouet A, Bilonda-Mutala L, Le Gac AL, Arnaud M, El Marjou A, Guerin C, Chaiyasitdhi A, Piquet J, Smadja DM, Cieslak A, Ryffel B, Maciulyte V, Turner JMA, Bernardeau K, Montagutelli X, Lantz O, Legoux F.   +24 more
europepmc   +2 more sources

Role of MAIT cells in pulmonary bacterial infection [PDF]

Molecular Immunology, 2018
Mucosal-associated invariant T (MAIT) cells represent a population of innate T cells that is highly abundant in humans. MAIT cells recognize metabolites of the microbial vitamin B pathway that are presented by the major histocompatibility complex (MHC ...
Nadine Hartmann, Melanie J Harriff, Curtis P Mcmurtrey   +2 more
exaly   +2 more sources

Monkeying around with MAIT Cells: Studying the Role of MAIT Cells in SIV and Mtb Co-Infection [PDF]

Viruses, 2021
There were an estimated 10 million new cases of tuberculosis (TB) disease in 2019. While over 90% of individuals successfully control Mycobacterium tuberculosis (Mtb) infection, which causes TB disease, HIV co-infection often leads to active TB disease ...
Ryan V. Moriarty, Amy L. Ellis, Shelby L. O’Connor   +2 more
core   +4 more sources

High pre-transplant Mucosal Associated Invariant T Cell (MAIT) count predicts favorable course of myeloid aplasia

Biomedical Papers
Aims. Mucosal Associated Invariant T (MAIT) cells are unconventional T cells with anti-infective potential. MAIT cells detect and fight against microbes on mucosal surfaces and in peripheral tissues.
Ivana Karlova Zubata, Jitka Smetanova Brozova, Tomas Karel, Barbora Bacova, Jan Novak   +4 more
doaj   +2 more sources