Results 11 to 20 of about 7,106 (183)
MAIT cells and the microbiome. [PDF]
Front Immunol, 2023 Mucosal associated invariant T (MAIT) cells are innate-like T lymphocytes, strikingly enriched at mucosal surfaces and characterized by a semi-invariant αβ T cell receptor (TCR) recognizing microbial derived intermediates of riboflavin synthesis presented by the MHC-Ib molecule MR1.
Jabeen MF, Hinks TSC.
europepmc +6 more sources
MAIT Cells in Liver Disease. [PDF]
CellsMucosal-associated invariant T (MAIT) cells are abundant innate-like T lymphocytes in the human liver which can provide antimicrobial defense, amplify inflammatory processes and mediate tissue repair and fibrosis depending on microenvironmental cues.
Azad AI, Gutierrez F, Gores GJ.
europepmc +4 more sources
MAIT Cell Activation and Functions [PDF]
Frontiers in Immunology, 2020 Mucosal associated invariant T (MAIT) cells are striking in their abundance and their strict conservation across 150 million years of mammalian evolution, implying they must fulfill critical immunological function(s). MAIT cells are defined by their expression of a semi-invariant αβ TCR which recognizes biosynthetic derivatives of riboflavin synthesis ...
Timothy S. C. Hinks +2 more
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A Role for MAIT Cells in Colorectal Cancer [PDF]
Frontiers in Immunology, 2020 MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties, but they have recently been associated with different forms of cancer. Several studies have reported activated MAIT cells within the microenvironment of colorectal tumors, but there is conjecture about the nature of their response and whether they are ...
Stuart P. Berzins +8 more
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Editorial: MAIT cells come of age. [PDF]
Front Immunol, 2023 Corbett AJ, Ussher JE, Hinks TSC.
europepmc +5 more sources
Frontiers in Immunology, 2017 Mucosal-associated invariant T (MAIT) cells are innate-like T cells which are important in the defense against certain bacteria and yeast. The reconstitution of MAIT cells after allogeneic hematopoietic stem cell transplantation (HSCT) is not known.
Martin Solders +8 more
doaj +1 more source
MAIT cells in liver inflammation and fibrosis
Seminars in Immunopathology, 2022 AbstractMucosal-associated invariant T cells or MAIT cells are an abundant cell type in humans and especially so in the liver. MAIT cells are a subset of T lymphocytes that sit at a bridge between innate and adaptive immunity, so-called innate-like or “unconventional” T cells.
Mehta, H +3 more
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iNKT and MAIT Cell Alterations in Diabetes [PDF]
Frontiers in Immunology, 2015 Type 1 diabetes (T1D) and type 2 diabetes (T2D) are multifactorial diseases with different etiologies in which chronic inflammation takes place. Defects in invariant natural killer T (iNKT) cell populations have been reported in both T1D and T2D patients, mouse models and our recent study revealed mucosal-associated invariant T (MAIT) cell defects in ...
Magalhaes, Isabelle +2 more
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MAIT cells: Conserved watchers on the wall. [PDF]
J Exp MedMAIT cells are innate-like T cells residing in barrier tissues such as the lung, skin, and intestine. Both the semi-invariant T cell receptor of MAIT cells and the restricting element MR1 are deeply conserved across mammals, indicating non-redundant functions linked to antigenic specificity.
Germain L, Veloso P, Lantz O, Legoux F.
europepmc +4 more sources
Frontiers in Immunology, 2023 Mucosal associated invariant T (MAIT) cells are a population of unconventional innate T cells due to their non-MHC restriction and rapid effector responses.
Nidhi Kedia-Mehta +4 more
doaj +1 more source