Results 41 to 50 of about 8,261 (205)

MAITabolism2 – the emerging understanding of MAIT cell metabolism and their role in metabolic disease

Frontiers in Immunology, 2023
Mucosal associated invariant T (MAIT) cells are a population of unconventional innate T cells due to their non-MHC restriction and rapid effector responses.
Nidhi Kedia-Mehta, Nidhi Kedia-Mehta, Andrew E. Hogan, Andrew E. Hogan, Andrew E. Hogan   +4 more
doaj   +1 more source

Human MAIT Cell Activation In Vitro [PDF]

, 2019
Mucosal-associated invariant T (MAIT) cells are an abundant innate-like T cell subset in humans, enriched in mucosal tissues and the liver. MAIT cells express a semi-invariant T cell receptor (TCR) and recognize microbial-derived riboflavin metabolites presented on the MHC Class I-like molecule MR1. In addition to activation via the TCR, MAIT cells can
Hagel, JP, Garner, LC, Bilton, M, Mehta, H, Leng, T, Hackstein, C-P, Phalora, P, Amini, A, Akther, HD, Provine, NM, Edmans, M, Willberg, CB, Klenerman, P   +12 more
openaire   +3 more sources

Biological functions of MAIT cells in tissues

Molecular Immunology, 2021
Mucosal associated invariant T (MAIT) cells have a recognised innate-like capacity for antibacterial host defence, consequent on the specificity of their T cell receptor (TCR) for small molecule metabolites produced by a range of prokaryotic and fungal species, their effector memory phenotype, and their expression of cytotoxic molecules.
Klenerman, Paul, Hinks, Timothy S.C., Ussher, James E.   +2 more
openaire   +2 more sources

CD4+/CD8+ mucosa-associated invariant T cells foster the development of endometriosis: a pilot study

Reproductive Biology and Endocrinology, 2019
Background Immune dysregulation is one of the mechanisms to promote endometriosis (EMS). Various T cell subpopulations have been reported to play different roles in the development of EMS.
Caihua Li, Zhimin Lu, Kaihuan Bi, Kangxia Wang, Yuping Xu, Peipei Guo, Ya Chen, Ping Zhou, Zhaolian Wei, Huanhuan Jiang, Yunxia Cao   +10 more
doaj   +1 more source

Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells, defined as CD161++TCR iVα7.2+ T cells, play an important role in the innate defense against bacterial infections, and their functionality is impaired in chronic viral infections.
Yean K. Yong, Yean K. Yong, Yean K. Yong, Alireza Saeidi, Hong Y. Tan, Hong Y. Tan, Hong Y. Tan, Hong Y. Tan, Mohamed Rosmawati, Philip F. Enström, Rami Al Batran, V. Vasuki, Indranil Chattopadhyay, Amudhan Murugesan, Ramachandran Vignesh, Adeeba Kamarulzaman, Adeeba Kamarulzaman, Jayakumar Rajarajeswaran, Abdul W. Ansari, Jamuna Vadivelu, James E. Ussher, Vijayakumar Velu, Marie Larsson, Esaki M. Shankar, Esaki M. Shankar, Esaki M. Shankar   +25 more
doaj   +1 more source

The role of mucosal associated invariant T cells in antimicrobial immunity

Frontiers in Immunology, 2015
Mucosal associated invariant T (MAIT) cells are an innate-like T cell subset prevalent in humans and distributed throughout the blood and mucosal sites. Human MAIT cells are defined by the expression of the semi-invariant TCRα chain TRAV1-2/TRAJ12/20/33 ...
Ruth J Napier, Erin J Adams, Erin J Adams, Erin J Adams, Marielle C Gold, Marielle C Gold, Marielle C Gold, David M Lewinsohn, David M Lewinsohn, David M Lewinsohn   +9 more
doaj   +1 more source

Circulating CD8+ mucosal‐associated invariant T cells correlate with improved treatment responses and overall survival in anti‐PD‐1‐treated melanoma patients

Clinical & Translational Immunology, 2022
Objectives While much of the research concerning factors associated with responses to immune checkpoint inhibitors (ICIs) has focussed on the contributions of conventional peptide‐specific T cells, the role of unconventional T cells, such as mucosal ...
Victoria M Vorwald, Dana M Davis, Robert J Van Gulick, Robert J Torphy, Jessica SW Borgers, Jared Klarquist, Kasey L Couts, Carol M Amato, Dasha T Cogswell, Mayumi Fujita, Moriah J Castleman, Timothy Davis, Catherine Lozupone, Theresa M Medina, William A Robinson, Laurent Gapin, Martin D McCarter, Richard P Tobin   +17 more
doaj   +1 more source

MAIT cells regulate NK cell-mediated tumor immunity [PDF]

, 2021
The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT cell-deficient mice have enhanced NK cell-dependent control of metastatic B16F10 tumor growth relative to control mice ...
Todd, KL, Kearney, CJ, Oliver, AJ, Pizzolla, A, Godfrey, DI, Li, J, Millen, R, McCulloch, TR, Chen, AXY, Oliaro, J, Giuffrida, L, Beavis, PA, Ramsay, RG, Mak, JYW, Petley, EV, Lai, J, Sek, K, Souza-Fonseca-Guimaraes, F, Michie, J, McCluskey, J, Keam, SP, Koay, HF, Fairlie, DP, Neeson, PJ, Zethoven, M, Freeman, AJ, House, IG, Darcy, PK, Huntington, ND, Henderson, MA, Chan, JD   +30 more
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Harnessing the Power of Mucosal-Associated Invariant T (MAIT) Cells in Cancer Cell Therapy

Biomedicines, 2022
Mucosal-associated invariant T (MAIT) cells, a burgeoning type of the innate-like T cells, play a crucial role in maintaining immune homeostasis, particularly in host defense.
Chie Sugimoto, Hiroyoshi Fujita, Hiroshi Wakao   +2 more
doaj   +1 more source

Isolation and Characterization of MAIT Cells from Tumor Tissues

, 2019
Mucosal-associated invariant T (MAIT) cell infiltration has been demonstrated in colorectal and hepatocellular carcinoma, and their ability to produce Th1- and Th17-associated cytokines, as well as their cytotoxic function, suggests that MAIT cells may ...
Quiding-Järbrink, Marianne,, William Rodin, Sundström, Patrik,, Patrik Sundström, Marianne Quiding Järbrink, Rodin, William,   +5 more
core   +1 more source