Clinical & Translational Immunology, 2022 Objectives While much of the research concerning factors associated with responses to immune checkpoint inhibitors (ICIs) has focussed on the contributions of conventional peptide‐specific T cells, the role of unconventional T cells, such as mucosal ...
Victoria M Vorwald +17 more
doaj +1 more source
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells [PDF]
, 2013 Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TCR) alpha-chain, TRAV1-2-TRAJ33, and are activated by vitamin B metabolites bound by the major histocompatibility complex (MHC)-related class I-like molecule ...
Birkinshaw, Richard W. +19 more
core +3 more sources
Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells [PDF]
, 2016 Mucosal-Associated Invariant T (MAIT) cells, present in high frequency in airway and other mucosal tissues, have Th1 effector capacity positioning them to play a critical role in the early immune response to intracellular pathogens, including ...
A Meierovics +42 more
core +7 more sources
iNKT and MAIT Cell Alterations in Diabetes [PDF]
Frontiers in Immunology, 2015 Type 1 diabetes (T1D) and type 2 diabetes (T2D) are multifactorial diseases with different etiologies in which chronic inflammation takes place. Defects in invariant natural killer T (iNKT) cell populations have been reported in both T1D and T2D patients, mouse models and our recent study revealed mucosal-associated invariant T (MAIT) cell defects in ...
Magalhaes, Isabelle +2 more
openaire +4 more sources
Monkeying around with MAIT Cells: Studying the Role of MAIT Cells in SIV and Mtb Co-Infection [PDF]
Viruses, 2021 There were an estimated 10 million new cases of tuberculosis (TB) disease in 2019. While over 90% of individuals successfully control Mycobacterium tuberculosis (Mtb) infection, which causes TB disease, HIV co-infection often leads to active TB disease.
Ryan V. Moriarty +2 more
openaire +3 more sources
The role of mucosal associated invariant T cells in antimicrobial immunity
Frontiers in Immunology, 2015 Mucosal associated invariant T (MAIT) cells are an innate-like T cell subset prevalent in humans and distributed throughout the blood and mucosal sites. Human MAIT cells are defined by the expression of the semi-invariant TCRα chain TRAV1-2/TRAJ12/20/33 ...
Ruth J Napier +9 more
doaj +1 more source
Stepwise development of MAIT cells in mouse and human. [PDF]
PLoS Biology, 2009 Mucosal-associated invariant T (MAIT) cells display two evolutionarily conserved features: an invariant T cell receptor (TCR)alpha (iTCRalpha) chain and restriction by the nonpolymorphic class Ib major histocompatibility complex (MHC) molecule, MHC ...
Emmanuel Martin +14 more
doaj +1 more source
Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses [PDF]
, 2014 Background: Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-adaptive interface. Methods: We measured MAIT cell frequencies and antibody
Aktar, Amena +13 more
core +3 more sources
MAIT cells in liver inflammation and fibrosis
Seminars in Immunopathology, 2022 AbstractMucosal-associated invariant T cells or MAIT cells are an abundant cell type in humans and especially so in the liver. MAIT cells are a subset of T lymphocytes that sit at a bridge between innate and adaptive immunity, so-called innate-like or “unconventional” T cells.
Hema Mehta +3 more
openaire +2 more sources
Mucosa-associated invariant T cells are systemically depleted in simian immunodeficiency virus-infected rhesus macaques [PDF]
, 2016 Mucosa-associated invariant T (MAIT) cells contribute to host immune protection against a wide range of potential pathogens via the recognition of bacterial metabolites presented by the major histocompatibility complex class I-related molecule MR1 ...
Brenchley, Jason M. +8 more
core +1 more source