Results 61 to 70 of about 8,261 (205)

MAIT cells and microbial immunity [PDF]

Immunology & Cell Biology, 2018
AbstractMucosal‐associated invariant T (MAIT) cells, the most abundant T‐cell subset in humans, are increasingly being recognized for their importance in microbial immunity. MAIT cells accumulate in almost every mucosal tissue examined, including the lung, liver and intestinal tract, where they can be activated through T‐cell receptor (TCR) triggering ...
Erin W Meermeier, Melanie J Harriff, Elham Karamooz, David M Lewinsohn   +3 more
openaire   +2 more sources

Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responses.

PLoS Pathogens
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that respond to riboflavin biosynthesis and cytokines through TCR-dependent and -independent pathways, respectively.
Shivam K Purohit, Lauren Stern, Alexandra J Corbett, Jeffrey Y W Mak, David P Fairlie, Barry Slobedman, Allison Abendroth   +6 more
doaj   +1 more source

Herpes simplex virus type 1 impairs mucosal-associated invariant T cells

mBio
Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that infects mucosal sites and adopts an arsenal of strategies to manipulate host immunity.
Lauren Stern, Zoe Emanuel, Renee Traves, Katherine Willis, Shivam K. Purohit, Carolyn Samer, Jeffrey Y. W. Mak, David P. Fairlie, David C. Tscharke, Alexandra J. Corbett, Allison Abendroth, Barry Slobedman   +11 more
doaj   +1 more source

CXCL16 Stimulates Antigen-Induced MAIT Cell Accumulation but Trafficking During Lung Infection Is CXCR6-Independent

Frontiers in Immunology, 2020
Mucosa-associated invariant T (MAIT) cells are a unique T cell subset that contributes to protective immunity against microbial pathogens, but little is known about the role of chemokines in recruiting MAIT cells to the site of infection.
Huifeng Yu, Amy Yang, Ligong Liu, Ligong Liu, Jeffrey Y. W. Mak, Jeffrey Y. W. Mak, David P. Fairlie, David P. Fairlie, Siobhan Cowley   +8 more
doaj   +1 more source

Clinicopathological and predictive value of MAIT cells in non-small cell lung cancer for immunotherapy

Journal for ImmunoTherapy of Cancer, 2023
Background Immune-checkpoint inhibitors (ICIs) remain ineffective in a large group of non-small cell lung cancer (NSCLC) patients. Mucosal-associated invariant T (MAIT) cells, a population of unconventional innate-like T lymphocytes abundant in the human
Dongyan Shi, Lin Lin, Yun Chen, Jian Liu, Lin Shi, Jinying Lu, Da Zhong, Meijuan Song, Wenhua You, Wen-Hui Li   +9 more
doaj   +1 more source

Globo‐H diagnostic stratification and identification of DUSP14 as a candidate target in colorectal cancer

International Journal of Cancer, EarlyView.
What's New? Colorectal cancer (CRC) is increasingly complicated by drug‐resistant tumors that limit the effectiveness of anticancer therapies. Because resistance mechanisms vary among patients and can evolve over time, personalized treatment strategies are needed.
Keren Zohar, Marco Strecker, Thomas Wartmann, Wenjie Shi, Frederike Stelter, Maximilian Doelling, Mihailo Andric, Or Kakhlon, Christian Täger, Denny Schanze, Michael Linnebacher, Michael Naumann, Daniel E. Stange, Dörthe Jechorek, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Development and Functions of MAIT Cells

Annual Review of Immunology
Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved T cells that recognize microbial metabolites. They are abundant in humans and conserved during mammalian evolution, which suggests that they have important nonredundant functions.
Salou, Marion, Paiva, Rafael A., Lantz, Olivier   +2 more
openaire   +2 more sources

Mucosal-Associated Invariant T Cells Redistribute to the Peritoneal Cavity During Spontaneous Bacterial Peritonitis and Contribute to Peritoneal InflammationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Mucosal-associated invariant T (MAIT) cells are depleted from blood in patients with advanced liver disease and show features of immune dysfunction.
Oluwatomi Ibidapo-obe, Sven Stengel, Nilay Köse-Vogel, Stefanie Quickert, Philipp A. Reuken, Martin Busch, Michael Bauer, Andreas Stallmach, Tony Bruns   +8 more
doaj   +1 more source

MAIT cells are reduced in frequency and functionally impaired in human T lymphotropic virus type 1 infection: Potential clinical implications. [PDF]

PLoS ONE, 2017
HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develop HAM/TSP.
Dominic Paquin-Proulx, Benjamin C Greenspun, Emanuela A S Costa, Aluisio C Segurado, Esper G Kallas, Douglas F Nixon, Fabio E Leal   +6 more
doaj   +1 more source

Human MAIT cells are cytotoxic.

, 2013
(A–B) Activation of purified MAIT (Vα7.2+CD161hi) cells cultured with Hela cells or Hela cells overexpressing the human MR1 protein (Hela-hMR1), in presence of increasing multiplicity of infections (MOI) of Escherichia coli (Ec).
Emmanuel Martin (95724), David Sleurs (469494), Stéphanie Bessoles (469492), Nacer-Eddine Serriari (469495), Emmanuel Treiner (266383), Claire Hivroz (221755), Mathilde Dusseaux (469491), Philippe Sansonetti (69367), Marie-Lise Gougeon (248350), Virginie Premel (266399), Maxime Coré (469493), Claire Soudais (64699), Armelle Bohineust (221753), Olivier Lantz (46680), Lionel Le Bourhis (60603)   +14 more
core   +1 more source