Results 61 to 70 of about 12,530 (222)

Biological functions of MAIT cells in tissues

Molecular Immunology, 2021
Mucosal associated invariant T (MAIT) cells have a recognised innate-like capacity for antibacterial host defence, consequent on the specificity of their T cell receptor (TCR) for small molecule metabolites produced by a range of prokaryotic and fungal species, their effector memory phenotype, and their expression of cytotoxic molecules.
Klenerman, Paul, Hinks, Timothy S.C., Ussher, James E.   +2 more
openaire   +2 more sources

Mucosal delivery of tuberculosis vaccines: a review of current approaches and challenges. [PDF]

, 2019
Introduction: Tuberculosis (TB) remains a major health threat and it is now clear that the current vaccine, BCG, is unable to arrest the global TB epidemic. A new vaccine is needed to either replace or boost BCG so that a better level of protection could
Barclay WR, Elena Stylianou, Helen McShane, Matthew J. Paul, Rajko Reljic, Resende Co T, Rodriguez A, Uranga S, Wong EA   +8 more
core   +1 more source

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

T cells, the next big target in axSpA?

Arthritis &Rheumatology, Accepted Article.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells.
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

MAIT Cell Adoptive Transfer v1 [PDF]

, 2020
This is part 3.2 of the "Study of MAIT Cell Activation in Viral Infections In Vivo" collection of protocols. Collection Abstract: MAIT cells are abundant, highly evolutionarily conserved innate-like lymphocytes expressing a semi-invariant T cell receptor (TCR), which recognizes microbially derived small intermediate molecules from the riboflavin ...
Timothy S C Hinks, Bonnie van Wilgenburg, Huimeng Wang, Liyen Loh, Marios Koutsakos, Katherine Kedzierska, Alexandra J. Corbett, Zhenjun Chen   +7 more
openaire   +1 more source

Mucosal-Associated Invariant T Cells Develop an Innate-Like Transcriptomic Program in Anti-mycobacterial Responses

Frontiers in Immunology, 2020
Conventional T cells exhibit a delayed response to the initial priming of peptide antigens presented by major histocompatibility complex (MHC) proteins.
Manju Sharma, Shuangmin Zhang, Liang Niu, David M. Lewinsohn, Xiang Zhang, Xiang Zhang, Shouxiong Huang, Shouxiong Huang   +7 more
doaj   +1 more source

Recipient mucosal-associated invariant T cells control GVHD within the colon [PDF]

, 2018
Mucosal-associated invariant T (MAIT) cells are a unique innate-like T cell subset that responds to a wide array of bacteria and yeast through recognition of riboflavin metabolites presented by the MHC class I–like molecule MR1.
Andrea S. Henden, Andrew D. Clouston, Antiopi Varelias, Cooke, David P. Fairlie, Geoffrey R. Hill, Hill, Hill, James McCluskey, Jamie Rossjohn, Jasmin Straube, Jeffrey Y.W. Mak, Kate H. Gartlan, Kate L. Ormerod, Kjer-Nielsen, Lars Kjer-Nielsen, Leanne Cooper, Mak, Mark D. Bunting, Martin, Motoko Koyama, Nancy Lachner, Olivier Lantz, Patel, Philip Hugenholtz, Rachel D. Kuns, Renee J. Robb, Steven W. Lane, Stuart D. Olver, Treiner, van Wilgenburg   +30 more
core   +3 more sources

Globo‐H diagnostic stratification and identification of DUSP14 as a candidate target in colorectal cancer

International Journal of Cancer, EarlyView.
What's New? Colorectal cancer (CRC) is increasingly complicated by drug‐resistant tumors that limit the effectiveness of anticancer therapies. Because resistance mechanisms vary among patients and can evolve over time, personalized treatment strategies are needed.
Keren Zohar, Marco Strecker, Thomas Wartmann, Wenjie Shi, Frederike Stelter, Maximilian Doelling, Mihailo Andric, Or Kakhlon, Christian Täger, Denny Schanze, Michael Linnebacher, Michael Naumann, Daniel E. Stange, Dörthe Jechorek, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

MAIT cells and tumor immunity [PDF]

Science, 2020
Cancer Immunology Mucosal-associated invariant T (MAIT) cells are immune cells that recognize host microbial metabolites presented by major histocompatibility complex class I–related protein 1 (MR1). During bacterial infection, activation of MAIT cells leads to the elimination of the infected cells.
openaire   +1 more source

Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responses.

PLoS Pathogens
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that respond to riboflavin biosynthesis and cytokines through TCR-dependent and -independent pathways, respectively.
Shivam K Purohit, Lauren Stern, Alexandra J Corbett, Jeffrey Y W Mak, David P Fairlie, Barry Slobedman, Allison Abendroth   +6 more
doaj   +1 more source