Results 81 to 90 of about 12,530 (222)

MAIT cells detect and efficiently lyse bacterially-infected epithelial cells.

PLoS Pathogens, 2013
Mucosal associated invariant T cells (MAIT) are innate T lymphocytes that detect a large variety of bacteria and yeasts. This recognition depends on the detection of microbial compounds presented by the evolutionarily conserved major-histocompatibility ...
Lionel Le Bourhis, Mathilde Dusseaux, Armelle Bohineust, Stéphanie Bessoles, Emmanuel Martin, Virginie Premel, Maxime Coré, David Sleurs, Nacer-Eddine Serriari, Emmanuel Treiner, Claire Hivroz, Philippe Sansonetti, Marie-Lise Gougeon, Claire Soudais, Olivier Lantz   +14 more
doaj   +1 more source

Mucosal-Associated Invariant T (MAIT) cells are highly activated in duodenal tissue of humans with Vibrio cholerae O1 infection: A preliminary report.

PLoS Neglected Tropical Diseases, 2022
Mucosal-associated invariant T (MAIT) cells are unconventional T lymphocytes with a semi-conserved TCRα, activated by the presentation of vitamin B metabolites by the MHC-I related protein, MR1, and with diverse innate and adaptive effector functions ...
Taufiqur R Bhuiyan, M Arifur Rahman, Shubhanshi Trivedi, Taliman Afroz, Hasan Al Banna, Mohammad Rubel Hoq, Ioana Pop, Owen Jensen, Rasheduzzaman Rashu, Muhammad Ikhtear Uddin, Motaher Hossain, Ashraful I Khan, Fahima Chowdhury, Jason B Harris, Stephen B Calderwood, Edward T Ryan, Firdausi Qadri, Daniel T Leung   +17 more
doaj   +1 more source

IL-17 Production from T Helper 17, Mucosal-Associated Invariant T, and γδ Cells in Tuberculosis Infection and Disease. [PDF]

, 2017
IL-17-producing cells have been shown to be important in the early stages of Mycobacterium tuberculosis (Mtb) infection in animal models. However, there are very little data on the role of IL-17 in human studies of tuberculosis (TB).
Coulter, Felicity, Garand, Mathieu, Kampmann, Beate, Lewinsohn, David M, Manning, Declan, Mendy, Joseph, Parrish, Amy, Riley, Eleanor M, Sutherland, Jayne S   +8 more
core   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

HIV-Infected Children Have Lower Frequencies of CD8+ Mucosal-Associated Invariant T (MAIT) Cells that Correlate with Innate, Th17 and Th22 Cell Subsets. [PDF]

PLoS ONE, 2016
Mucosal-associated invariant T cells (MAIT) are innate T cells restricted by major histocompatibility related molecule 1 (MR1) presenting riboflavin metabolite ligands derived from microbes.
Alka Khaitan, Max Kilberg, Adam Kravietz, Tiina Ilmet, Cihan Tastan, Mussa Mwamzuka, Fatma Marshed, Mengling Liu, Aabid Ahmed, William Borkowsky, Derya Unutmaz   +10 more
doaj   +1 more source

T Cell Heterogeneity Shaped by Alternative Splicing Predicts Prognosis in Hepatocellular Carcinoma

Cancer Science, EarlyView.
T cell‐specific alternative splicing events shape T cell heterogeneity in HCC. Single‐cell analysis identified two splicing‐defined T cell subpopulations with distinct functional profiles. Subpopulation‐associated splicing events were used to construct a prognostic model predicting patient survival.
Xiaohui Peng, Zhenli Li, Xiuqing Dong, Zhixiong Cai, Chenfan Lu, Junjie Gao, Shuyue You, Yuwen Wang, Jianming Mao, Xiaolong Liu, Geng Chen, Yingchao Wang   +11 more
wiley   +1 more source

Mucosal-associated invariant T cells in patients with axial spondyloarthritis

Frontiers in Immunology, 2023
BackgroundSeveral studies implicate Th17-cells and its cytokine (IL-17) in disease pathogenesis of spondyloarthritis (SpA), with available evidence supporting a pathogenic role of CD8+ T-cells.
Rienk Gerben van der Meer, Anneke Spoorenberg, Elisabeth Brouwer, Berber Doornbos-van der Meer, Annemieke M. H. Boots, Suzanne Arends, Wayel H. Abdulahad, Wayel H. Abdulahad   +7 more
doaj   +1 more source

Role of innate T cells in anti-bacterial immunity [PDF]

, 2015
Innate T cells are a heterogeneous group of αβ and γδ T cells that respond rapidly (
Aggarwal, Arigoni, Battistini, Behr, Bendelac, Berzins, Berzofsky, Billerbeck, Bonneville, Brandes, Brennan, Brigl, Brigl, Buchmeier, Carreno, Carvalho, Chackerian, Chua, Cohen, Collins, Darmoise, De Libero, DiTirro, Dusseaux, Eguchi, Espinosa, Fergusson, Fernandez, Fletcher, Fujita, Gao, Georgel, Giabbai, Godfrey, Gold, Gold, Grimaldi, Harly, He, Horikoshi, Ivanov, Joyce, Joyee, Kalyan, Kawakami, Kee, Kinjo, Kinjo, Kinjo, Kjer-Nielsen, Kroca, Lanier, Le Bourhis, Leslie, Lo, Luoma, Maggi, Martin, Mattner, Meierovics, Miyagawa, Morita, Nauciel, Olszak, Paget, Paget, Paget, Paget, Park, Pechhold, Reantragoon, Reantragoon, Russano, Sada-Ovalle, Salio, Sandstrom, Sarikonda, Seach, Shin, Silva, Skeen, Sriram, Stanic, Takahashi, Tessmer, Tilloy, Tupin, Turtle, Uldrich, Ussher, van der Sluijs, Van Kaer, Vavassori, Voyle, Wingender, Wong, Wong, Wu, Xiao, Yuling, Zheng   +100 more
core   +1 more source

Single Cell Multi‐Omics Revealing the Important Role of MR1 Mediated MAIT Cells in Maintaining Rejection for Liver Transplantation

Cell Proliferation, EarlyView.
This multi‐omics study reveals the significant role of MAIT cells in liver transplant rejection. MAIT cells drive rejection in liver transplantation via the MR1 axis. Their absence reshapes T cell responses and clonal expansion, attenuating allograft injury.
Hailun Cai, Xinqiang Li, Xin Zhou, Xueteng Wang, Zhuoyu Jia, Ruidong Ding, Yurong Luo, Ye Wang, Shipeng Li, Wenxing Sun, Dongxing Wu, Dahong Teng, Kai Zhao, Guanghui Pei, Jinzhen Cai, Bin Wu   +15 more
wiley   +1 more source

MAIT cells: new guardians of the liver [PDF]

Clinical & Translational Immunology, 2016
The liver is an important immunological organ that remains sterile and tolerogenic in homeostasis, despite continual exposure to non‐self food and microbial‐derived products from the gut. However, where intestinal mucosal defenses are breached or in the presence of a systemic infection, the liver acts as a second 'firewall', because of its enrichment ...
Kurioka A, Walker LJ, Klenerman P, Willberg C   +3 more
openaire   +5 more sources