Results 91 to 100 of about 8,261 (205)

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

MAIT cells and tumor immunity [PDF]

Science, 2020
Cancer Immunology Mucosal-associated invariant T (MAIT) cells are immune cells that recognize host microbial metabolites presented by major histocompatibility complex class I–related protein 1 (MR1). During bacterial infection, activation of MAIT cells leads to the elimination of the infected cells.
openaire   +1 more source

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.

PLoS Pathogens, 2015
Mucosa-associated invariant T (MAIT) cells represent a large innate-like evolutionarily conserved antimicrobial T-cell subset in humans. MAIT cells recognize microbial riboflavin metabolites from a range of microbes presented by MR1 molecules. MAIT cells
Edwin Leeansyah, Jenny Svärd, Joana Dias, Marcus Buggert, Jessica Nyström, Máire F Quigley, Markus Moll, Anders Sönnerborg, Piotr Nowak, Johan K Sandberg   +9 more
doaj   +1 more source

Mucosal-Associated Invariant T (MAIT) cells are highly activated in duodenal tissue of humans with Vibrio cholerae O1 infection: A preliminary report.

PLoS Neglected Tropical Diseases, 2022
Mucosal-associated invariant T (MAIT) cells are unconventional T lymphocytes with a semi-conserved TCRα, activated by the presentation of vitamin B metabolites by the MHC-I related protein, MR1, and with diverse innate and adaptive effector functions ...
Taufiqur R Bhuiyan, M Arifur Rahman, Shubhanshi Trivedi, Taliman Afroz, Hasan Al Banna, Mohammad Rubel Hoq, Ioana Pop, Owen Jensen, Rasheduzzaman Rashu, Muhammad Ikhtear Uddin, Motaher Hossain, Ashraful I Khan, Fahima Chowdhury, Jason B Harris, Stephen B Calderwood, Edward T Ryan, Firdausi Qadri, Daniel T Leung   +17 more
doaj   +1 more source

MAIT cells protect against pulmonary Legionella longbeachae infection [PDF]

, 2018
Mucosal associated invariant T (MAIT) cells recognise conserved microbial metabolites from riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate them in antibacterial host defence, yet their functions in protection ...
Fairlie, David P., Hinks, Timothy S.C., Godfrey, DI, Wang, Huimeng, Wang, Nancy, Pediongco, TJ, Godfrey, Dale I., Kjer-Nielsen, Lars, Westall, Glen P., Meehan, BS, Mak, JYW, Corbett, AJ, Hinks, Timothy S. C., D'Souza, C, Iwakura, Y, Eckle, Sidonia B. G., Shi, Mai, Eckle, Sidonia B.G., Kostenko, L, Eckle, SBG, Strugnell, RA, Gunnersen, JM, Meehan, Bronwyn S., D’Souza, C, Rossjohn, Jamie, Kjer-Nielsen, L, Hinks, Timothy Stopford, D'Souza, Criselle, Chen, Z, Mak, Jeffrey Y.W., Liu, Ligong, Pediongco, Troi J., Gunnersen, Jennifer M., McCluskey, James, Shi, M, Westall, GP, Liu, L, Stent, AW, Lim, Xin Yi, Wang, H, D’Souza, Criselle, Hinks, TSC, Wang, N, Chen, Zhenjun, McCluskey, J, Lim, X, Fairlie, DP, Rossjohn, J, Corbett, Alexandra J., Strugnell, Richard A., Kostenko, Lyudmila, Stent, Andrew W., Mak, Jeffrey Y. W., Li, Shihan, Iwakura, Yoichiro, Li, S, Lim, XY   +56 more
core   +1 more source

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini, E. Tartaglia, F. Cristofanelli, S. Gili, F. Maggi   +4 more
wiley   +1 more source

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1231-1244, June 2026.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Multi‐omics insights for deciphering prognosis‐related T cell subsets in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
An integrated multi‐omics analysis delineates the prognostic landscape of T‐cell subsets in hepatocellular carcinoma. DPT cells and HBEGF‐related signals are associated with poor survival in hepatocellular carcinoma. Endothelial‐derived HBEGF recruits DPT cells, which in turn up‐regulate the EMT signatures and drive the migration of hepatocellular ...
Guangzu Cui, Erya Hu, Qingping Peng, Xin Zhou, Yu Zhao, Haicong Liu, Xinwen Wang, Yihong Chen, Hong Shen, Shan Zeng, Jiayao Ma   +10 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Mucosal-associated invariant T cells in cancer: dual roles, complex interactions and therapeutic potential

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells play diverse roles in cancer, infectious diseases, and immunotherapy. This review explores their intricate involvement in cancer, from early detection to their dual functions in promoting inflammation and ...
Mesut Yigit, Omer Faruk Basoglu, Derya Unutmaz   +2 more
doaj   +1 more source