Results 111 to 120 of about 12,530 (222)

Role of mucosal-associated invariant T cells dynamics in pathogenesis of Sjögren syndrome

Scientific Reports
Sjögren syndrome (SS) is an autoimmune disease characterized by chronic inflammatory infiltrates in the salivary and lacrimal glands. Mucosal-associated invariant T (MAIT) cells are a subset of innate-like T-cells, predominantly found in mucosal tissues ...
Jeanne Chauffier, Henri Berger de Gallardo, Mathieu F. Chevalier, Aïcha Kante, Marion Lambert, Xavier Cabrol, Elisa Aldersons, Stéphane Mouly, Karine Champion, Blanca Amador-Borrero, Ruxandra Burlacu, William Bigot, Homa Adle-Biassete, Rachid Kaci, Aurélie Selvanadin, Martine Cohen-Solal, Amélie Coudert, Sophie Caillat-Zucman, Damien Sène, Cloé Comarmond   +19 more
doaj   +1 more source

Conventional, regulatory, and unconventional T cells in the immunologic response to helicobacter pylori [PDF]

, 2008
Infection by the gastroduodenal pathogen Helicobacter pylori elicits a complex immunologic response in the mucosa involving neutrophils, plasma cells, eosinophils, and lymphocytes, of which T cells are the principal orchestrators of immunity.
Moran, Anthony P., O'Keeffe, Joan
core   +1 more source

Integrated Bulk and Single‐Cell RNA‐Seq Analysis Reveals Transcriptional Activation of PTGS2 by FOS in Progression From T2DM to T2DM‐Associated NAFLD

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) frequently coexist, exacerbating disease burden. However, the molecular mechanisms underlying the progression from T2DM to T2DM‐associated NAFLD remain unclear. This study investigated the regulatory function of FOS‐mediated PTGS2 activation in this transition.
Rong Lin, Leqin Xu, Yi Zhou, Yanjing Fan, Huan Xie, Wanzhang Li, Tianchi Hu, Chao Liu   +7 more
wiley   +1 more source

Increased pathogenicity and pro-inflammatory capabilities of mucosal-associated invariant T cells involved in Oral Lichen Planus

BMC Oral Health
Background Mucosal-associated invariant T (MAIT) cells assume pivotal roles in numerous autoimmune inflammatory maladies. However, scant knowledge exists regarding their involvement in the pathological progression of oral lichen planus (OLP).
Siting Chen, Xiaoli Wu, Yinshen Yang, Xiaoheng Xu, Xiaoqin Xiong, Wenxia Meng   +5 more
doaj   +1 more source

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.

PLoS Pathogens, 2015
Mucosa-associated invariant T (MAIT) cells represent a large innate-like evolutionarily conserved antimicrobial T-cell subset in humans. MAIT cells recognize microbial riboflavin metabolites from a range of microbes presented by MR1 molecules. MAIT cells
Edwin Leeansyah, Jenny Svärd, Joana Dias, Marcus Buggert, Jessica Nyström, Máire F Quigley, Markus Moll, Anders Sönnerborg, Piotr Nowak, Johan K Sandberg   +9 more
doaj   +1 more source

Recognition of vitamin B metabolites by mucosal-associated invariant T cells [PDF]

, 2013
The mucosal-associated invariant T-cell antigen receptor (MAIT TCR) recognizes MR1 presenting vitamin B metabolites. Here we describe the structures of a human MAIT TCR in complex with human MR1 presenting a non-stimulatory ligand derived from folic acid
A Bendelac, AG Leslie, AW Schuttelkopf, C Cosgrove, DG Pellicci, DI Godfrey, DI Godfrey, DI Godfrey, DI Godfrey, DN Garboczi, E Girardi, E Girardi, E Leeansyah, E Treiner, F Tilloy, FE Tynan, G Vera, J Rossjohn, KS Wun, L Kjer-Nielsen, L Kjer-Nielsen, L Le Bourhis, L Le Bourhis, MC Gold, MC Gold, NA Borg, O Patel, PH Zwart, R Reantragoon, S Gras, S Huang, S Huang, SJ Turner, TS Mikkelsen, WJ Chua, X-Z Tang, Y Miyazaki   +36 more
core   +1 more source

Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection

JCI Insight, 2021
Progress in our understanding of MR1-restricted mucosa-associated invariant T (MAIT) cells has raised interest in harnessing these cells for immunotherapy.
Tiphaine Parrot, Katie Healy, Caroline Boulouis, Michał J. Sobkowiak, Edwin Leeansyah, Soo Aleman, Antonio Bertoletti, Margaret Sällberg Chen, Johan K. Sandberg   +8 more
doaj   +1 more source

Complex Adaptive Immunity to Enteric Fevers in Humans: Lessons Learned and the Path Forward [PDF]

, 2014
Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, and S. Paratyphi A and B, causative agents of paratyphoid fever, are major public health threats throughout the world.
Marcelo B. Sztein, Monica A. McArthur, Rosangela Salerno-Goncalves   +2 more
core   +2 more sources

Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential [PDF]

, 2016
Ajudes rebudes: Marie Curie Career Integration Grant; Dexeus Foundation for Women's Health Research; i Contratos Ramón y CajalCD11c is an α integrin classically employed to define myeloid dendritic cells.
A Arakelyan, Annie Rodolosse, Antoni Tarrats, B Ljutic, C Sadhu, CC Denucci, CE Egan, D Fujiwara, D Ganguly, DC Bullard, DI Godfrey, DJ Pennington, DL Farber, DM Williams, E Billerbeck, E Gonzalez-Roca, GK Smyth, J Del Campo, Jamal Qualai, JC Grivel, JD Haas, JJ Moon, JM Fuller, Jon Cantero, JR Fergusson, JW Huleatt, K Kubota, LA Cooney, Lauro Sumoy, Lin-Xi Li, LS Cauley, LX Li, M Beyer, M Brandes, M Eberl, M Kuka, M Roederer, Marco Antonio Fernández, Meritxell Genescà, N Lycke, NA Bezman, OS Qureshi, PA Romagnoli, R. Keith Reeves, RT Trifonova, S Paul, S Tsai, SM Tan, Stephen J. McSorley, T Vorup-Jensen, YH Kim, Z Chen   +51 more
core   +5 more sources

Liver transplant-facilitated CD161+Vα7.2+ MAIT cell recovery demonstrates clinical benefits in hepatic failure patients

Nature Communications
Mucosal-associated invariant T (MAIT) cells exert multifaceted effects such as anti-microbial activity, tissue repair, and pro-fibrotic effects across various disease settings. Nonetheless, their role in liver injury and hemostasis remains debated. Here,
Wei Wang, Chen Dai, Peng Zhu, Mi Wu, Haoquan Zhang, Qing Wei, Ting Zhou, Xiaosheng Tan, Ying Jiang, Xue Cheng, Zhihui Liang, Xiongwen Wu, Zhishui Chen, Xiufang Weng   +13 more
doaj   +1 more source