Results 1 to 10 of about 11,692 (232)

Mucosal-Associated Invariant T Cells in Autoimmune Diseases

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells are innate T cells restricted by MHC-related molecule 1 (MR1). MAIT cells express semi-invariant T-cell receptors TRAV1-2-TRAJ33/12/20 in humans and TRAV1-TRAJ33 in mice.
Asako Chiba, Goh Murayama, Sachiko Miyake   +2 more
doaj   +4 more sources

Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells [PDF]

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are innate-like T cells that function at the interface between innate and adaptive immunity.
Lucy C. Garner, Paul Klenerman, Paul Klenerman, Nicholas M. Provine   +3 more
doaj   +6 more sources

Human mucosal associated invariant T cells detect bacterially infected cells. [PDF]

PLoS Biology, 2010
Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilution
Marielle C Gold, Stefania Cerri, Susan Smyk-Pearson, Meghan E Cansler, Todd M Vogt, Jacob Delepine, Ervina Winata, Gwendolyn M Swarbrick, Wei-Jen Chua, Yik Y L Yu, Olivier Lantz, Matthew S Cook, Megan D Null, David B Jacoby, Melanie J Harriff, Deborah A Lewinsohn, Ted H Hansen, David M Lewinsohn   +17 more
doaj   +3 more sources

Varicella Zoster Virus infects mucosal associated Invariant T cells [PDF]

Frontiers in Immunology, 2023
IntroductionMucosal Associated Invariant T (MAIT) cells are innate-like T cells that respond to conserved pathogen-derived vitamin B metabolites presented by the MHC class I related-1 molecule (MR1) antigen presentation pathway.
Shivam K. Purohit, Alexandra J. Corbett, Barry Slobedman, Allison Abendroth   +3 more
doaj   +2 more sources

Mucosal-associated invariant T cells in patients with axial spondyloarthritis [PDF]

Frontiers in Immunology, 2023
BackgroundSeveral studies implicate Th17-cells and its cytokine (IL-17) in disease pathogenesis of spondyloarthritis (SpA), with available evidence supporting a pathogenic role of CD8+ T-cells.
Rienk Gerben van der Meer, Anneke Spoorenberg, Elisabeth Brouwer, Berber Doornbos-van der Meer, Annemieke M. H. Boots, Suzanne Arends, Wayel H. Abdulahad, Wayel H. Abdulahad   +7 more
doaj   +2 more sources

TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses

Cell Reports, 2019
Summary: Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor (TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin biosynthesis, or via cytokines.
Rajesh Lamichhane, Marion Schneider, Sara M. de la Harpe, Thomas W.R. Harrop, Rachel F. Hannaway, Peter K. Dearden, Joanna R. Kirman, Joel D.A. Tyndall, Andrea J. Vernall, James E. Ussher   +9 more
doaj   +3 more sources

The role of mucosal associated invariant T cells in antimicrobial immunity

Frontiers in Immunology, 2015
Mucosal associated invariant T (MAIT) cells are an innate-like T cell subset prevalent in humans and distributed throughout the blood and mucosal sites. Human MAIT cells are defined by the expression of the semi-invariant TCRα chain TRAV1-2/TRAJ12/20/33 ...
Ruth J Napier, Erin J Adams, Erin J Adams, Erin J Adams, Marielle C Gold, Marielle C Gold, Marielle C Gold, David M Lewinsohn, David M Lewinsohn, David M Lewinsohn   +9 more
doaj   +3 more sources

The alterations of circulating mucosal-associated invariant T cells in polycystic ovary syndrome

Frontiers in Endocrinology, 2022
BackgroundPolycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting reproductive age females and an important cause of infertility.
Hong Zhou, Junting Xu, Ling Hong, Yanping Jia, Lilo Valerie Burk, Fengli Chi, Mei Zhao, Xiaohong Guan, Dan Liu, Xiangjie Yin, Yiqiao Zhang, Xiaoming Teng, Liyan Duan, Liyan Duan, Kunming Li   +14 more
doaj   +1 more source

ROLE OF MUCOSAL-ASSOCIATED INVARIANT T CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2021
The etiology of inflammatory and autoimmune diseases is complex and not yet fully understood. Their pathogenesis includes mechanisms in which both innate and adaptive immune cells are involved. Mucosal-associated invariant T (MAIT) cells are immune cells
rehab mekkawy, Omnia El-badawy, Helal F. Hetta, Doaa K. Abd El-hafez, Khaled M. Hassanein   +4 more
doaj   +1 more source

Emerging Roles of Mucosal-Associated Invariant T Cells in Rheumatology

Frontiers in Immunology, 2022
Mucosal-associated invariant T (MAIT) cells are an unconventional T cell subset expressing a semi-invariant TCR and recognize microbial riboflavin metabolites presented by major histocompatibility complex class 1-related molecule (MR1).
Yanmei Li, Jun Du, Wei Wei
doaj   +1 more source