Results 31 to 40 of about 11,692 (232)

Invariant Natural Killer T and Mucosal-Associated Invariant T Cells in Asthmatic Patients

Frontiers in Immunology, 2018
Recent studies have highlighted the heterogeneity of asthma. Distinct patient phenotypes (symptoms, age at onset, atopy, and lung function) may result from different pathogenic mechanisms, including airway inflammation, remodeling, and immune and ...
Guillaume Lezmi, Guillaume Lezmi, Guillaume Lezmi, Maria Leite-de-Moraes, Maria Leite-de-Moraes   +4 more
doaj   +1 more source

Persistent deficiency of mucosal-associated invariant T cells during dermatomyositis

, 2020
International audienceObjectives: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that are important for antibacterial immunity and may have regulatory roles. MAIT cells are decreased during SLE.
Bagot, Martine, Branchtein, Mylene, Bachmeyer, Claude, Amoura, Zahir, Mathian, Alexis, Bengoufa, Djaouida, Cordoliani, Florence, Bouaziz, Jean-David, Bensussan, Armand, de Masson, Adèle, Monfort, Jean-Benoit, Le Buanec, Hélène, Frumholtz, Laure, Lepelletier, Clémence, Battistella, Maxime, Amode, Reyhan, Jachiet, Marie, Cassius, Charles, Chasset, François, Samri, Assia   +19 more
core   +2 more sources

Mucosal-Associated Invariant T Cell Interactions with Commensal and Pathogenic Bacteria: Potential Role in Antimicrobial Immunity in the Child

Frontiers in Immunology, 2017
Mucosal-associated invariant T (MAIT) cells are unconventional CD3+CD161high T lymphocytes that recognize vitamin B2 (riboflavin) biosynthesis precursor derivatives presented by the MHC-I related protein, MR1. In humans, their T cell receptor is composed
Liana Ghazarian, Sophie Caillat-Zucman, Sophie Caillat-Zucman, Véronique Houdouin, Véronique Houdouin   +4 more
doaj   +1 more source

The role of mucosal-associated invariant T cells in visceral leishmaniasis

Frontiers in Immunology, 2022
Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by ...
Marcela de Lima Moreira, Marcela de Lima Moreira, Luana Oliveira Borges-Fernandes, Marcelo Antônio Pascoal-Xavier, Marcelo Antônio Pascoal-Xavier, Ágata Lopes Ribeiro, Victória Hellena Silva Pereira, Troi Pediongco, Márcio Sobreira da Silva Araújo, Andréa Teixeira-Carvalho, Andrea Lucchesi de Carvalho, Maria Vitória Assumpção Mourão, Flávia Alves Campos, Marineide Borges, Mariângela Carneiro, Zhenjun Chen, Eleanor Saunders, Malcolm McConville, Moriya Tsuji, James McCluskey, Olindo Assis Martins-Filho, Sidonia Barbara Guiomar Eckle, Jordana Grazziela Alves Coelho-dos-Reis, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhães   +24 more
doaj   +1 more source

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

Cell Reports, 2019
Summary: Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer+ cells derived from either human blood or murine
Timothy S.C. Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J. Pediongco, Bronwyn S. Meehan, Lyudmila Kostenko, Stephen J. Turner, Alexandra J. Corbett, Zhenjun Chen, Paul Klenerman, James McCluskey   +12 more
doaj   +1 more source

Effector functions of mucosal associated invariant T cells in response to viral infections and vaccines

, 2023
The rapid propagation of host immune responses following nucleic-acid sensing is necessary for protection against viruses and vaccines. Cytokines, such as type I interferon (IFN), play a key role.
Amini, Ali
core   +1 more source

Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections

Frontiers in Immunology, 2018
The immune system has been traditionally divided into two arms called innate and adaptive immunity. Typically, innate immunity refers to rapid defense mechanisms that set in motion within minutes to hours following an insult.
François Trottein, François Trottein, François Trottein, François Trottein, François Trottein, Christophe Paget, Christophe Paget   +6 more
doaj   +1 more source

Peripheral and intestinal mucosal-associated invariant T cells in premature infants with necrotizing enterocolitis

Frontiers in Pharmacology, 2022
Background: Necrotizing enterocolitis (NEC) is a potentially fatal inflammatory gastrointestinal disease in preterm infants with unknown pathogenesis. Mucosal-associated invariant T (MAIT) cells primarily accumulate at sites where exposure to microbes is
Jiayi Tian, Chaoying Yan, Yanfang Jiang, Haohan Zhou, Liyuan Li, Jingjing Shen, Jian Wang, Hongyu Sun, Guang Yang, Wei Sun   +9 more
doaj   +1 more source

Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells

Nature Communications, 2020
Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental ...
S. Harsha Krovi, Jingjing Zhang, Mary Jessamine Michaels-Foster, Tonya Brunetti, Liyen Loh, James Scott-Browne, Laurent Gapin   +6 more
doaj   +1 more source

B cells modulate mucosal associated invariant T cell (MAIT) immune responses

Frontiers in Immunology, 2014
A common finding when measuring T cell immunity to enteric bacterial vaccines in humans is the presence of background responses among individuals before immunization. Yet the nature of these background responses remains largely unknown. Recent findings
Rosangela eSalerno-Goncalves, Tasmia eRezwan, Marcelo B. Sztein   +2 more
doaj   +1 more source