Results 51 to 60 of about 11,692 (232)

Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis

Arthritis Research & Therapy, 2019
Background Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognise bacterial metabolites presented by MHC class I-related protein 1 (MR1). Bacterial dysbiosis has been implicated in auto-inflammatory disease development.
Hester Koppejan, Diahann T. S. L. Jansen, Marjolijn Hameetman, Ranjeny Thomas, Rene E. M. Toes, Floris A. van Gaalen   +5 more
doaj   +1 more source

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity [PDF]

, 2020
International audienceObesity is associated with low-grade chronic inflammation promoting insulin-resistance and diabetes. Gut microbiota dysbiosis is a consequence as well as a driver of obesity and diabetes.
Maguin, E, Lesnik, P, Lesnik, Philippe, da Silva, J, Lehuen, A, Maguin, Emmanuelle, Simoni, Yannick, Toubal, A, Cagninacci, L, Simoni, Y, Agnès Lehuen, Rhimi, M, Blandine Fruchet, Jennifer da Silva, Amine Toubal, da Silva, Jennifer, Corbett, AJ, Lantz, O, Yannick Simoni, Corbett, Alexandra, J, Kiaf, Badr, McCluskey, J, Beaudoin, Lucie, Fruchet, Blandine, Badr Kiaf, Corbett, Alexandra, Toubal, Amine, Alexandra J. Corbett, Cagninacci, Lucie, Olivier Lantz, Lucie Cagninacci, Rossjohn, J, Moez Rhimi, Jamie Rossjohn, Rhimi, Moez, Corbett, Alexandra J., Lantz, Olivier, Beaudoin, L, Fruchet, B, Kiaf, B, Mccluskey, James, Philippe Lesnik, Emmanuelle Maguin, Rossjohn, Jamie, Lehuen, Agnès, Lucie Beaudoin, James McCluskey   +46 more
core   +1 more source

Mucosal Associated Invariant T Cells in Cancer-Friend or Foe? [PDF]

, 2021
Mucosal associated invariant T (MAIT) cells are a population of unconventional T cells which can bridge the innate and adaptive immune systems. Well-described roles for MAIT cells include host protection against invading bacteria, fungi and viruses ...
Hogan, Andrew E., O’Neill, Chloe, Chloe O’Neill, Andrew E. Hogan, Cassidy, Féaron C., Féaron C. Cassidy, O’Shea, Donal, Donal O’Shea   +7 more
core   +1 more source

Rapid Fabrication of Self‐Propelled and Steerable Magnetic Microcatheters for Precision Medicine

Advanced Materials, EarlyView.
A rapid Joule heating fabrication method for the production of self‐propelling, adaptive microcatheters, with tunable stiffness and integrated microfluidic channels is presented. Demonstrated through three microrobotic designs, including a steerable guiding catheter, an untethered wave‐crawling TubeBot, and a distal‐end propelled microcatheter, it was ...
Zhi Chen, Boris Rivkin, David Castellanos‐Robles, Ivan Soldatov, Lukas Beyer, Mariana Medina‐Sánchez   +5 more
wiley   +1 more source

Regulatory T cells and mucosal-associated invariant T cells in colon adenocarcinomas; Phenotype and function [PDF]

, 2019
In many solid cancers, and also in colon adenocarcinomas, an increased accumulation of lymphocytes is beneficial for the patient. However, tumor-infiltrating immune cells may be either pro- or anti-tumorigenic and the balance between these two ...
Ahlmanner, Filip
core  

Hard‐Magnetic Soft Millirobots in Underactuated Systems

Advanced Robotics Research, EarlyView.
This review provides a comprehensive overview of hard‐magnetic soft millirobots in underactuated systems. It examines key advances in structural design, physics‐informed modeling, and control strategies, while highlighting the interplay among these domains.
Qiong Wang, Zixuan Zhang, Bingyan Li, Junkai Wang, Hongcheng Gu   +4 more
wiley   +1 more source

Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

Nature Communications, 2021
Mucosal-Associated Invariant T (MAIT) cells are associated with established functions during bacterial infection. Here the authors show inoculation with Francisella tularensis results in induction of MAIT cells associated with prototypic Th1 immunity and
Zhe Zhao, Huimeng Wang, Mai Shi, Tianyuan Zhu, Troi Pediongco, Xin Yi Lim, Bronwyn S. Meehan, Adam G. Nelson, David P. Fairlie, Jeffrey Y. W. Mak, Sidonia B. G. Eckle, Marcela de Lima Moreira, Carolin Tumpach, Michael Bramhall, Cameron G. Williams, Hyun Jae Lee, Ashraful Haque, Maximilien Evrard, Jamie Rossjohn, James McCluskey, Alexandra J. Corbett, Zhenjun Chen   +21 more
doaj   +1 more source

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Differential Skewing of Circulating MR1-Restricted and γδ T Cells in Human Psoriasis Vulgaris

Frontiers in Immunology, 2020
Psoriasis vulgaris (PV) is a chronic, recurrent inflammatory dermatosis mediated by aberrantly activated immune cells. The role of the innate-like T cells, particularly gammadelta T (γδT) cells and MR1-restricted T lymphocytes, is incompletely explored ...
Vera Plužarić, Vera Plužarić, Mario Štefanić, Martina Mihalj, Martina Mihalj, Maja Tolušić Levak, Maja Tolušić Levak, Ivanka Muršić, Ljubica Glavaš-Obrovac, Martin Petrek, Peter Balogh, Stana Tokić   +11 more
doaj   +1 more source