Results 51 to 60 of about 19,288 (276)

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers [PDF]

, 2015
Studies on the biology of mucosal-associated invariant T cells (MAIT cells) in mice have been hampered by a lack of specific reagents. Using MR1-antigen (Ag) tetramers that specifically bind to the MR1-restricted MAIT T cell receptors (TCRs), we ...
Chen, Zhenjun, Clanchy, Rhiannon, Eckle, Sidonia B. G., Enders, Anselm, Fairlie, David P., Godfrey, Dale I., Goodnow, Chris C., Koay, Hui Fern, Liu, Ligong, McCluskey, James, Meehan, Bronwyn, Pellicci, Daniel G., Rahimpour, Azad, Rossjohn, Jamie, Uldrich, Adam P., Whittle, Belinda   +15 more
core   +3 more sources

Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells

Nature Communications, 2020
Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental ...
S. Harsha Krovi, Jingjing Zhang, Mary Jessamine Michaels-Foster, Tonya Brunetti, Liyen Loh, James Scott-Browne, Laurent Gapin   +6 more
doaj   +1 more source

Low Levels of Peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) Cells Are Found in HIV and HIV/TB Co-Infection [PDF]

, 2014
Background: High expression of CD161 on CD8+ T cells is associated with a population of cells thought to play a role in mucosal immunity. We wished to investigate this subset in an HIV and Mycobacterium tuberculosis (MTB) endemic African setting. Methods:
Akilimali, Ngomu Akeem, Bishai, William R., Cosgrove, Cormac, Govender, Pamla, Kasprowicz, Victoria O., Klenerman, Paul, Lewinsohn, David M., Ndung'u, Thumbi, Pillay, Mona, Sullivan, Zuri A., Walker, Bruce D., Wong, Emily B.   +11 more
core   +1 more source

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

Nature Communications, 2016
Mucosal-associated invariant T (MAIT) cells sense riboflavin biosynthetic intermediate antigens with a semi-invariant MR1-restricted T-cell receptor (TCR). Here the authors identify a new MR1-restricted TCR that senses cells infected with S.
Erin W. Meermeier, Bruno F. Laugel, Andrew K. Sewell, Alexandra J. Corbett, Jamie Rossjohn, James McCluskey, Melanie J. Harriff, Tamera Franks, Marielle C. Gold, David M. Lewinsohn   +9 more
doaj   +1 more source

Bacteria, mucosal‐associated invariant T cells and MR1 [PDF]

Immunology & Cell Biology, 2010
Certain subpopulations of T lymphoctyes show innate-like properties that distinguish them from conventional T cells and thus have been collectively termed innate T cells. Two extensively studied subsets of innate T cells implicated in pathogen detection are invariant natural killer T (iNKT) cells and γδ T cells. Conventional T cells detect pathogens in
Wei‐Jen Chua, Ted H Hansen
openaire   +1 more source

Invariant NKT cells and rheumatic disease: Focus on primary sjogren syndrome [PDF]

, 2019
Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology.
Barbera L. L., Ciccia F., Guggino G., Pizzo M. L., Rizzo C., Sireci G.   +5 more
core   +1 more source

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +2 more sources

Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection [PDF]

, 2012
Mucosa-associated invariant T (MAIT) cells are a unique population of αβ T cells in mammals that reside preferentially in mucosal tissues and express an invariant Vα paired with limited Vβ T-cell receptor (TCR) chains.
Andersen, Annibali, Azra Blazevic, Berrington, Berzins, Billerbeck, Borg, Brennan, Brigl, Brigl, Chiba, Cho, Christopher S. Eickhoff, Chua, Chua, Cogen, Cohen, Cooper, Cooper, Cowley, Cowley, Croxford, Cua, Curtis, D'Souza, D'Souza, Daniel F. Hoft, Dusseaux, Elkins, Feng, Flesch, Flynn, Flynn, Gansert, Georgel, Gold, Gold, Goldfinch, Gopal, Green, Hansen, Huang, Huang, Huang, J. L. Flynn, Jovanovic, Junqueira-Kipnis, Kariyone, Kawachi, Khader, Khader, Kinjo, Ladel, Le Bourhis, Lin, Lockhart, Lozes, MacMicking, Martin, Miley, Misko, Miyazaki, Nagarajan, Parker, Parra, Pollock, Qian, Riegert, Rodgers, Sada-Ovalle, Schoenborn, Shimamura, Skold, Sousa, Steven M. Truscott, Ted H. Hansen, Tilloy, Treiner, Treiner, Tupin, Tyznik, Urdahl, Wei-Jen Chua, Worku, Yamaguchi, Yamaguchi, Zhang   +86 more
core   +2 more sources

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells [PDF]

, 2013
Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TCR) alpha-chain, TRAV1-2-TRAJ33, and are activated by vitamin B metabolites bound by the major histocompatibility complex (MHC)-related class I-like molecule ...
Birkinshaw, Richard W., Chen, Zhenjun, Corbett, Alexandra J., Eckle, Sidonia B. G., Fairlie, David P., Furness, John B., Gherardin, Nicholas A., Godfrey, Dale I., Hansen, Ted H., Kedzierska, Katherine, Kjer-Nielsen, Lars, Kostenko, Lyudmila, Liu, Ligong, McCluskey, James, Meehan, Bronwyn, Patel, Onisha, Reantragoon, Rangsima, Rossjohn, Jamie, Sakala, Isaac G., Uldrich, Adam P.   +19 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source