Results 61 to 70 of about 19,288 (276)

MAIT cells in metabolic diseases

Molecular Metabolism, 2019
Background: Metabolic diseases represent a wide category of alterations affecting metabolism. These pathologies are notably marked by inflammation that implicates the immune system.
Léo Bertrand, Agnès Lehuen
doaj   +1 more source

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells [PDF]

, 2017
Mucosal-associated invariant T (MAIT) cells are activated by unstable antigens formed by reactions of 5-amino-6-D-ribitylaminouracil (a vitamin B2 biosynthetic intermediate) with glycolysis metabolites such as methylglyoxal.
Chen, Zhenjun, Corbett, Alexandra J., Fairlie, David P., Liu, Ligong, Mak, Jeffrey Y. W., McCluskey, James, Meehan, Bronwyn S., Reid, Robert C., Rossjohn, Jamie, Wang, Huimeng, Xu, Weijun   +10 more
core   +4 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Lymphoma caused by intestinal microbiota. [PDF]

, 2014
The intestinal microbiota and gut immune system must constantly communicate to maintain a balance between tolerance and activation: on the one hand, our immune system should protect us from pathogenic microbes and on the other hand, most of the millions ...
Schiestl, Robert H, Yamamoto, Mitsuko L
core   +2 more sources

3D‐Printed Porous Hydroxyapatite Formed via Enzymatic Mineralization

Advanced Functional Materials, EarlyView.
Bone combines lightness, strength, and the ability to heal, inspiring new materials design. This work introduces a room‐temperature, enzyme‐mediated 3D printing method to create porous hydroxyapatite scaffolds. The process avoids energy‐intensive sintering, preserves bioactivity, and allows control over porosity and mineralization.
Francesca Bono, Anna Puiggalí‐Jou, Greta Cocchi, Mariangela Miccoli, Katharina Maniura‐Weber, Marcy Zenobi‐Wong, Esther Amstad   +6 more
wiley   +1 more source

Latent Mycobacterium tuberculosis Infection Is Associated With a Higher Frequency of Mucosal-Associated Invariant T and Invariant Natural Killer T Cells

Frontiers in Immunology, 2018
Increasing drug resistance and the lack of an effective vaccine are the main factors contributing to Mycobacterium tuberculosis (Mtb) being a major cause of death globally.
Dominic Paquin-Proulx, Priscilla R. Costa, Cassia G. Terrassani Silveira, Mariana P. Marmorato, Natalia B. Cerqueira, Matthew S. Sutton, Shelby L. O’Connor, Karina I. Carvalho, Douglas F. Nixon, Esper G. Kallas   +9 more
doaj   +1 more source

Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

Nature Communications, 2021
Mucosal-Associated Invariant T (MAIT) cells are associated with established functions during bacterial infection. Here the authors show inoculation with Francisella tularensis results in induction of MAIT cells associated with prototypic Th1 immunity and
Zhe Zhao, Huimeng Wang, Mai Shi, Tianyuan Zhu, Troi Pediongco, Xin Yi Lim, Bronwyn S. Meehan, Adam G. Nelson, David P. Fairlie, Jeffrey Y. W. Mak, Sidonia B. G. Eckle, Marcela de Lima Moreira, Carolin Tumpach, Michael Bramhall, Cameron G. Williams, Hyun Jae Lee, Ashraful Haque, Maximilien Evrard, Jamie Rossjohn, James McCluskey, Alexandra J. Corbett, Zhenjun Chen   +21 more
doaj   +1 more source

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18–dependent activation [PDF]

, 2016
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes known to elicit potent immunity to a broad range of bacteria, mainly via the rapid production of inflammatory cytokines. Whether MAIT cells contribute to antiviral immunity is less
Corbett, Alexandra J., Crowe, Jane, Doherty, Peter C., Fairlie, David P., Jegaskanda, Sinthujan, Kedzierska, Katherine, Koutsakos, Marios, Liu, Ligong, Loh, Liyen, McCluskey, James, Rossjohn, Jamie, Sant, Sneha, Wang, Zhongfang, Xu, Jianqing   +13 more
core   +2 more sources

Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus [PDF]

The Journal of Immunology, 2014
Abstract Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections and play an important role in mucosal immunity. However, the role of MAIT cells remains enigmatic in autoimmune diseases.
Young-Nan, Cho, Seung-Jung, Kee, Tae-Jong, Kim, Hye Mi, Jin, Moon-Ju, Kim, Hyun-Ju, Jung, Ki-Jeong, Park, Sung-Ji, Lee, Shin-Seok, Lee, Yong-Soo, Kwon, Hae Jin, Kee, Nacksung, Kim, Yong-Wook, Park   +12 more
openaire   +2 more sources

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source