Results 1 to 10 of about 9,846 (113)

Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells [PDF]

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are innate-like T cells that function at the interface between innate and adaptive immunity.
Lucy C. Garner, Paul Klenerman, Paul Klenerman, Nicholas M. Provine   +3 more
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B cells modulate mucosal associated invariant T cell (MAIT) immune responses [PDF]

Frontiers in Immunology, 2014
A common finding when measuring T cell immunity to enteric bacterial vaccines in humans is the presence of background responses among individuals before immunization. Yet the nature of these background responses remains largely unknown. Recent findings
Rosangela eSalerno-Goncalves, Tasmia eRezwan, Marcelo B. Sztein   +2 more
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TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses

Cell Reports, 2019
Summary: Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor (TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin biosynthesis, or via cytokines.
Rajesh Lamichhane, Marion Schneider, Sara M. de la Harpe, Thomas W.R. Harrop, Rachel F. Hannaway, Peter K. Dearden, Joanna R. Kirman, Joel D.A. Tyndall, Andrea J. Vernall, James E. Ussher   +9 more
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Hantaan virus infection induces human mucosal-associated invariant T cell pyroptosis through IRE1α pathway [PDF]

Communications Biology
Hantaan virus (HTNV) triggers an epidemic of hemorrhagic fever with renal syndrome (HFRS), which is predominantly prevalent in Asia. Mucosal-associated invariant T (MAIT) cells, categorized as innate-like T lymphocytes, perform crucial functions in the ...
Yusi Zhang, He Liu, Dalu Liu, Huiyuan Zhang, Ying Ma, Na Li, Chunmei Zhang, Manling Xue, Fenglan Wang, Xiaozhou Jia, Hui Zhang, Kang Tang, Xiaoyue Xu, Shijia Wang, Yiwen Wei, Xiaojing Yang, Jiajia Zuo, Lihua Chen, Boquan Jin, Yun Zhang   +19 more
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Insights into mucosal associated invariant T cell biology from human inborn errors of immunity [PDF]

Frontiers in Immunology, 2022
Lauren J. Howson, Lauren J. Howson, Vanessa L. Bryant, Vanessa L. Bryant, Vanessa L. Bryant   +4 more
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Mucosal-associated invariant T cell is a potential marker to distinguish fibromyalgia syndrome from arthritis. [PDF]

PLoS ONE, 2015
Fibromyalgia (FM) is defined as a widely distributed pain. While many rheumatologists and pain physicians have considered it to be a pain disorder, psychiatry, psychology, and general medicine have deemed it to be a syndrome (FMS) or psychosomatic ...
Chie Sugimoto, Takahiko Konno, Rika Wakao, Hiroko Fujita, Hiroyoshi Fujita, Hiroshi Wakao   +5 more
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Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes

Frontiers in Immunology, 2021
Mucosal surfaces, as a first barrier with the environment are especially susceptible to damage from both pathogens and physical trauma. Thus, these sites require tightly regulated repair programs to maintain barrier function in the face of such insults ...
Joshua R. Cox, Joshua R. Cox, Sheena M. Cruickshank, Amy E. Saunders, Amy E. Saunders   +4 more
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MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection

Frontiers in Immunology, 2021
Mucosal associated invariant T (MAIT) cells are a class of innate-like T cells that utilize a semi-invariant αβ T cell receptor to recognize small molecule ligands produced by bacteria and fungi.
Sharon Khuzwayo, Sharon Khuzwayo, Maphe Mthembu, Maphe Mthembu, Erin W. Meermeier, Sanjay M. Prakadan, Sanjay M. Prakadan, Sanjay M. Prakadan, Samuel W. Kazer, Samuel W. Kazer, Samuel W. Kazer, Thierry Bassett, Kennedy Nyamande, Dilshaad Fakey Khan, Priya Maharaj, Mohammed Mitha, Moosa Suleman, Moosa Suleman, Zoey Mhlane, Dirhona Ramjit, Farina Karim, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, David M. Lewinsohn, David M. Lewinsohn, David M. Lewinsohn, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Emily B. Wong, Emily B. Wong, Emily B. Wong, Emily B. Wong   +36 more
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Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections

Frontiers in Immunology, 2021
Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells that utilize a semi-invariant T cell receptor (TCR) α chain and are restricted by the highly conserved antigen presenting molecule MR1.
Matthew D. Edmans, Matthew D. Edmans, Timothy K. Connelley, Siddharth Jayaraman, Christina Vrettou, Martin Vordermeier, Martin Vordermeier, Jeffrey Y. W. Mak, Jeffrey Y. W. Mak, Ligong Liu, Ligong Liu, Ligong Liu, David P. Fairlie, David P. Fairlie, David P. Fairlie, Emmanuel Atangana Maze, Tiphany Chrun, Paul Klenerman, Sidonia B. G. Eckle, Elma Tchilian, Lindert Benedictus, Lindert Benedictus   +21 more
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Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells

Nature Communications, 2020
Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental ...
S. Harsha Krovi, Jingjing Zhang, Mary Jessamine Michaels-Foster, Tonya Brunetti, Liyen Loh, James Scott-Browne, Laurent Gapin   +6 more
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