Results 11 to 20 of about 9,945 (212)

MAIT Cell Activation and Functions

Frontiers in Immunology, 2020
Mucosal associated invariant T (MAIT) cells are striking in their abundance and their strict conservation across 150 million years of mammalian evolution, implying they must fulfill critical immunological function(s).
Timothy S. C. Hinks, Xia-Wei Zhang, Xia-Wei Zhang   +2 more
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Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation

Nature Communications, 2022
Human cytomegalovirus is a major cause of morbidity and mortality in transplant patients and multiple immune cells types are critical during infection and reactivation.
Lauren Stern, Helen M. McGuire, Selmir Avdic, Barbara Fazekas de St Groth, David Gottlieb, Allison Abendroth, Emily Blyth, Barry Slobedman   +7 more
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Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

Cell Reports, 2019
Summary: Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer+ cells derived from either human blood or murine
Timothy S.C. Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J. Pediongco, Bronwyn S. Meehan, Lyudmila Kostenko, Stephen J. Turner, Alexandra J. Corbett, Zhenjun Chen, Paul Klenerman, James McCluskey   +12 more
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Antigen Recognition by MR1-Reactive T Cells; MAIT Cells, Metabolites, and Remaining Mysteries

Frontiers in Immunology, 2020
Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors (TCR) and MR1 are highly conserved among mammals, suggesting an important ...
Alexandra J. Corbett, Wael Awad, Wael Awad, Huimeng Wang, Huimeng Wang, Zhenjun Chen   +5 more
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Harnessing the Power of Mucosal-Associated Invariant T (MAIT) Cells in Cancer Cell Therapy

Biomedicines, 2022
Mucosal-associated invariant T (MAIT) cells, a burgeoning type of the innate-like T cells, play a crucial role in maintaining immune homeostasis, particularly in host defense.
Chie Sugimoto, Hiroyoshi Fujita, Hiroshi Wakao   +2 more
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How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets

Frontiers in Immunology, 2018
In contrast to peptide-recognizing T cells, invariant natural killer T (iNKT) cells express a semi-invariant T cell receptor that specifically recognizes self- or foreign-lipids presented by CD1d molecules.
Haiguang Wang, Kristin A. Hogquist
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MAIT cells activate dendritic cells to promote TFH cell differentiation and induce humoral immunity

Cell Reports, 2023
Summary: Protective immune responses against respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the mucosal immune system.
Theresa E. Pankhurst, Kaitlin H. Buick, Joshua L. Lange, Andrew J. Marshall, Kaileen R. Button, Olga R. Palmer, Kathryn J. Farrand, Isabelle Montgomerie, Thomas W. Bird, Ngarangi C. Mason, Joanna Kuang, Benjamin J. Compton, Davide Comoletti, Mariolina Salio, Vincenzo Cerundolo, Miguel E. Quiñones-Mateu, Gavin F. Painter, Ian F. Hermans, Lisa M. Connor   +18 more
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Mucosal-Associated Invariant T Cells Expressing the TRAV1-TRAJ33 Chain Are Present in Pigs

Frontiers in Immunology, 2019
Mucosal-associated invariant T (MAIT) cells are a subpopulation of evolutionarily conserved innate-like T lymphocytes bearing invariant or semi-invariant TCRα chains paired with a biased usage of TCRβ chains and restricted by highly conserved monomorphic
Xingxing Xiao, Xingxing Xiao, Kun Li, Xueting Ma, Xueting Ma, Baohong Liu, Baohong Liu, Xueyang He, Xueyang He, Shunli Yang, Shunli Yang, Wenqing Wang, Wenqing Wang, Baoyu Jiang, Jianping Cai, Jianping Cai   +15 more
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Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

Nature Communications, 2016
Mucosal-associated invariant T (MAIT) cells sense riboflavin biosynthetic intermediate antigens with a semi-invariant MR1-restricted T-cell receptor (TCR). Here the authors identify a new MR1-restricted TCR that senses cells infected with S.
Erin W. Meermeier, Bruno F. Laugel, Andrew K. Sewell, Alexandra J. Corbett, Jamie Rossjohn, James McCluskey, Melanie J. Harriff, Tamera Franks, Marielle C. Gold, David M. Lewinsohn   +9 more
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Mucosal-Associated Invariant T Cells in the Digestive System: Defender or Destroyer?Summary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Mucosal-associated invariant T (MAIT) cells are a subset of innate T lymphocytes that express the semi-invariant T cell receptor and recognize riboflavin metabolites via the major histocompatibility complex class I–related protein. Given the abundance of
Hejiao Zhang, Haiyuan Shen, Liangliang Zhou, Linxi Xie, Derun Kong, Hua Wang   +5 more
doaj   +1 more source