Results 21 to 30 of about 9,945 (212)

Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy

Nature Communications, 2021
Immune checkpoint inhibition (ICI) shows potential for cancer therapies, but response rates vary. Here, the authors use single-cell analyses to show that, in a 28 patient cohort, patients stratified by mucosal-associated invariant T (MAIT) percentages ...
Sara De Biasi, Lara Gibellini, Domenico Lo Tartaro, Simone Puccio, Claudio Rabacchi, Emilia M. C. Mazza, Jolanda Brummelman, Brandon Williams, Kelly Kaihara, Mattia Forcato, Silvio Bicciato, Marcello Pinti, Roberta Depenni, Roberto Sabbatini, Caterina Longo, Massimo Dominici, Giovanni Pellacani, Enrico Lugli, Andrea Cossarizza   +18 more
doaj   +1 more source

Editorial: Exploring unconventional T cells and CAR-T-cells in cancer immunotherapy [PDF]

Frontiers in Immunology
Laura Patrussi, Chenran Zhang
doaj   +2 more sources

Development of Unconventional T Cells Controlled by MicroRNA

Frontiers in Immunology, 2019
Post-transcriptional gene regulation through microRNA (miRNA) has emerged as a major control mechanism of multiple biological processes, including development and function of T cells. T cells are vital components of the immune system, with conventional T
Samantha J. Winter, Andreas Krueger
doaj   +1 more source

Target tumor microenvironment by innate T cells

Frontiers in Immunology, 2022
The immunosuppressive tumor microenvironment (TME) remains one of the most prevailing barriers obstructing the implementation of effective immunotherapy against solid-state cancers.
Yan-Ruide Li, Matthew Wilson, Lili Yang, Lili Yang, Lili Yang, Lili Yang   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Circulating Mucosal‐Associated Invariant T Cells Are Associated With Acute Human Ischemic Stroke and Predict Poor Outcome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Mucosal‐associated invariant T (MAIT) cells are involved in acute ischemic stroke in mice models. This study aimed to clarify the dynamics and role of circulating MAIT cells in patients with acute ischemic stroke.
Tadashi Ozawa, Asako Chiba, Hiroko Hayakawa, Tsukasa Ohmori, Sachiko Miyake, Shigeru Fujimoto, Ryota Tanaka   +6 more
doaj   +1 more source

Circulating Mucosal-Associated Invariant T Cells in a Large Cohort of Healthy Chinese Individuals From Newborn to Elderly

Frontiers in Immunology, 2019
Mucosal-associated invariant T (MAIT) cells, which are enriched in human blood and express a semi-invariant TCR chain, play important roles in conditions such as infectious diseases and cancer.
Pengcheng Chen, Pengcheng Chen, Wenhai Deng, Dandan Li, Tai Zeng, Ling Huang, Qun Wang, Jinli Wang, Weiguang Zhang, Xiaoxiao Yu, Deming Duan, Jinle Wang, Hong Xia, Hanbin Chen, Wesley Huang, Jingao Li, Dahong Zhang, Xiao-Ping Zhong, Xiao-Ping Zhong, Jimin Gao   +19 more
doaj   +1 more source