Results 41 to 50 of about 9,945 (212)

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications

Journal of Inflammation
Mucosal-associated invariant T (MAIT) cells are an atypical subset of T lymphocytes, which have a highly conserved semi-constant αβ chain of T-cell receptor (TCR) and recognize microbe-derived vitamin B metabolites via major histocompatibility complex ...
Xue Lin, Ye Wang, Yanqi He
doaj   +1 more source

RNAseq of INOCA patients identifies innate, invariant, and acquired immune changes: potential autoimmune microvascular dysfunction

Frontiers in Cardiovascular Medicine
BackgroundIschemia with non-obstructive coronary arteries (INOCA) is a major clinical entity that involves potentially 20%–30% of patients with chest pain.
Kevin Jaatinen, Palak Shah, Ramesh Mazhari, Zane Hayden, Richard Wargowsky, Tisha Jepson, Tisha Jepson, Tisha Jepson, Ian Toma, Ian Toma, John Perkins, Timothy A. McCaffrey, Timothy A. McCaffrey, Timothy A. McCaffrey   +13 more
doaj   +1 more source

Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.

PLoS Pathogens, 2014
Non-conventional T lymphocytes constitute a special arm of the immune system and act as sentinels against pathogens at mucosal surfaces. These non-conventional T cells (including mucosal-associated invariant T [MAIT] cells, gamma delta [γδ] T cells, and ...
Stoyan Ivanov, Christophe Paget, François Trottein   +2 more
doaj   +1 more source

Role of innate T cells in anti-bacterial immunity

Frontiers in Immunology, 2015
Innate T cells are a heterogeneous group of αβ and γδ T cells that respond rapidly (
Yifang eGao, Anthony P Williams, Anthony P Williams   +2 more
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Identification of altered immune cell types and molecular mechanisms in Alzheimer’s disease progression by single-cell RNA sequencing

Frontiers in Aging Neuroscience
IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by gradual loss of cognitive function. Understanding the molecular mechanisms is crucial for developing effective therapies.MethodsData from single-cell RNA ...
Hua Lin, Li Su, Daniel Mao, Grace Yang, Qi Huang, Yating Lan, Jingyi Zeng, Wenyi Song, Guining Liang, Qingyan Wei, Donghua Zou, Rongjie Li, Chanhua Zou   +12 more
doaj   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Mucosal-associated invariant T cells recognize a tumor-derived metabolite in the DNA synthesis pathway

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells recognize metabolite-derived ligands, but the identity of such ligands in the context of cancer remains poorly defined.
Yanqi Xue, Yuka Yamada, Rikako Suzuki, Brenda Luong, Shotaro Fujii, Keisuke Nakata, Masatomo Takahashi, Yoshihiro Izumi, Chihiro Fukui, Ryosuke Takasaki, Francois Legoux, Shinsuke Inuki, Shinsuke Inuki, Daisuke Motooka, Emi Ito, Bridget L. Stocker, Mattie S. M. Timmer, Takashi Shimizu, Yasumasa Matsuoka, Jun’ichi Mano, Koji Tamada, Koji Tamada, Makoto Furutani-Seiki, Kei Sakamoto, Koh-Hei Sonoda, Olivier Lantz, Sho Yamasaki, Sho Yamasaki, Sho Yamasaki, Sho Yamasaki, Sho Yamasaki, Kensuke Shibata, Kensuke Shibata, Kensuke Shibata   +33 more
doaj   +1 more source

Differential location of NKT and MAIT cells within lymphoid tissue

Scientific Reports, 2022
Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant αβ T cell receptors (TCRs) through which they recognise CD1d and MR1 molecules, respectively, in complex with specific ...
Darryl N. Johnson, Zheng Ruan, Emma V. Petley, Sapna Devi, Lauren E. Holz, Adam P. Uldrich, Jeffrey Y. W. Mak, Jyh Liang Hor, Scott N. Mueller, James McCluskey, David P. Fairlie, Phillip K. Darcy, Paul A. Beavis, William R. Heath, Dale I. Godfrey   +14 more
doaj   +1 more source