Invariant natural killer T cells in lung diseases [PDF]
Experimental and Molecular Medicine, 2023 Invariant natural killer T (iNKT) cells are a subset of T cells that are characterized by a restricted T-cell receptor (TCR) repertoire and a unique ability to recognize glycolipid antigens.
Dongjin Jeong +2 more
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Harnessing invariant natural killer T cells to control pathological inflammation [PDF]
Frontiers in Immunology, 2022 Invariant natural killer T (iNKT) cells are innate T cells that are recognized for their potent immune modulatory functions. Over the last three decades, research in murine models and human observational studies have revealed that iNKT cells can act to ...
Nikhila S. Bharadwaj, Jenny E. Gumperz
doaj +5 more sources
Invariant Natural Killer T Cells [PDF]
Antibodies, 2013 Invariant Natural killer T cell (iNKT cells) are a subset of T cells, which are narrowly defined as a T cell lineage expressing a semi-invariant CD1d-restricted T cell Receptors (TCRs) composed by Vα24-Jα18/Vβ11 in human, and Vα14-Jα18/Vβ8,Vβ7, and Vβ2 ...
Antonella Cianferoni
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Invariant Natural Killer T cells coordinate removal of senescent cells. [PDF]
Med, 2021 Background The failure of immune surveillance to remove senescent cells drive age-related diseases. Here, we target an endogenous immune surveillance mechanism that can promote elimination of senescent cells and reverse disease progression.
Arora S +11 more
europepmc +6 more sources
Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells [PDF]
Frontiers in Immunology, 2018 Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are innate-like T cells that function at the interface between innate and adaptive immunity.
Lucy C. Garner +3 more
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Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention. [PDF]
Stem Cell Res Ther, 2022 New COVID-19 treatments are desperately needed as case numbers continue to rise and emergent strains threaten vaccine efficacy. Cell therapy has revolutionized cancer treatment and holds much promise in combatting infectious disease, including COVID-19 ...
Li YR +11 more
europepmc +2 more sources
Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury [PDF]
iScience, 2023 Summary: Invariant Natural Killer T (iNKT) cell activation by α-galactosylceramide (αGC) potentiates cytotoxic immune responses against tumors. However, αGC-induced liver injury is a limiting factor for iNKT-based immunotherapy.
Michelangelo Bauwelz Gonzatti +7 more
doaj +2 more sources
Zeb2 regulates differentiation of long-lived effector of invariant natural killer T cells [PDF]
Communications Biology, 2023 After activation, some invariant natural killer T (iNKT) cells are differentiated into Klrg1+ long-lived effector NKT1 cells. However, the regulation from the effector phase to the memory phase has not been elucidated.
Tomonori Iyoda +9 more
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Preclinical Evaluation of Invariant Natural Killer T Cells Modified with CD38 or BCMA Chimeric Antigen Receptors for Multiple Myeloma. [PDF]
Int J Mol Sci, 2021 Due to the CD1d restricted recognition of altered glycolipids, Vα24-invariant natural killer T (iNKT) cells are excellent tools for cancer immunotherapy with a significantly reduced risk for graft-versus-host disease when applied as off-the shelf ...
Poels R +8 more
europepmc +2 more sources
Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients [PDF]
Frontiers in Cell and Developmental Biology, 2022 Background: Psoriasis is a common immune-mediated skin disease that involves T-cell-mediated immunity. Invariant natural killer T (iNKT) cells are a unique lymphocyte subpopulation that share properties and express surface markers of both NK cells and T ...
Yifan Hu +25 more
doaj +2 more sources