The two faces of invariant natural killer T cells
Biomedical Journal, 2015 In this issue of the Biomedical Journal, we take a look at some of the immune system's most peculiar cells, invariant natural killer T cells, which have features of both innate and adaptive cells.
Emma L. Walton
doaj +6 more sources
Invariant natural killer T cells in lung diseases [PDF]
Experimental and Molecular Medicine, 2023 Invariant natural killer T (iNKT) cells are a subset of T cells that are characterized by a restricted T-cell receptor (TCR) repertoire and a unique ability to recognize glycolipid antigens.
Dongjin Jeong +2 more
doaj +4 more sources
Invariant natural killer T cells minimally influence gut microbiota composition in mice [PDF]
Gut Microbes, 2022 Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate-like functions and produce copious amounts of cytokines, chemokines and cytotoxic
Qiaochu Lin +10 more
doaj +3 more sources
Harnessing invariant natural killer T cells to control pathological inflammation [PDF]
Frontiers in Immunology, 2022 Invariant natural killer T (iNKT) cells are innate T cells that are recognized for their potent immune modulatory functions. Over the last three decades, research in murine models and human observational studies have revealed that iNKT cells can act to ...
Nikhila S. Bharadwaj, Jenny E. Gumperz
doaj +2 more sources
Invariant natural killer T cells balance B cell immunity. [PDF]
Immunol Rev, 2021 AbstractInvariant natural killer T (iNKT) cells mediate rapid immune responses which bridge the gap between innate and adaptive responses to pathogens while also providing key regulation to maintain immune homeostasis. Both types of important iNKT immune responses are mediated through interactions with innate and adaptive B cells.
Leadbetter EA, Karlsson MCI.
europepmc +5 more sources
Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury [PDF]
iScience, 2023 Summary: Invariant Natural Killer T (iNKT) cell activation by α-galactosylceramide (αGC) potentiates cytotoxic immune responses against tumors. However, αGC-induced liver injury is a limiting factor for iNKT-based immunotherapy.
Michelangelo Bauwelz Gonzatti +7 more
doaj +2 more sources
Zeb2 regulates differentiation of long-lived effector of invariant natural killer T cells [PDF]
Communications Biology, 2023 After activation, some invariant natural killer T (iNKT) cells are differentiated into Klrg1+ long-lived effector NKT1 cells. However, the regulation from the effector phase to the memory phase has not been elucidated.
Tomonori Iyoda +9 more
doaj +2 more sources
Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients [PDF]
Frontiers in Cell and Developmental Biology, 2022 Background: Psoriasis is a common immune-mediated skin disease that involves T-cell-mediated immunity. Invariant natural killer T (iNKT) cells are a unique lymphocyte subpopulation that share properties and express surface markers of both NK cells and T ...
Yifan Hu +25 more
doaj +2 more sources
Re-programming mouse liver-resident invariant natural killer T cells for suppressing hepatic and diabetogenic autoimmunity [PDF]
Nature Communications, 2022 Invariant natural killer T (iNKT) cells are tissue-resident immune cells recognizing lipid antigens. Here the authors find that liver, but not lung nor spleen, iNKT cells alter their transcriptome upon systemic treatment of lipid nanoparticles for the ...
Channakeshava Sokke Umeshappa +14 more
doaj +2 more sources
Invariant natural killer T cells are functionally impaired in patients with systemic sclerosis [PDF]
Arthritis Research & Therapy, 2019 Background Systemic sclerosis (SSc) is a potentially fatal autoimmune disease that leads to extensive fibrosis of the skin and internal organs. Invariant natural killer T (iNKT) cells are potent immunoregulatory T lymphocytes being able to orchestrate ...
Ann-Christin Pecher +12 more
doaj +2 more sources