Results 41 to 50 of about 15,260 (267)
The role of invariant natural killer T cells in microbial immunity [PDF]
Journal of Infection and Chemotherapy, 2013 Invariant natural killer T cells (iNKT cells) are unique lymphocytes with characteristic features, such as expression of an invariant T-cell antigen receptor (TCR) α-chain, recognition of glycolipid antigens presented by CD1d molecules, and ability to rapidly produce large amounts of cytokines, including interferon-γ (IFN-γ) and interleukin 4 (IL-4 ...
Yuki, Kinjo +2 more
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The Role of Invariant Natural Killer T Cells in Lupus and Atherogenesis [PDF]
Immunologic Research, 2006 Systemic lupus erythematosus (SLE) is increasingly recognized as a risk factor for the development of premature atherosclerosis. The inflammatory process in both of these diseases is controlled by a variety of cell types of the innate and adaptive immune systems.
Amy S, Major +3 more
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Homeostatic regulation of marginal zone B cells by invariant natural killer T cells. [PDF]
PLoS ONE, 2011 Marginal zone B cells (MZB) mount a rapid antibody response, potently activate naïve T cells, and are enriched in autoreactive B cells. MZBs express high levels of CD1d, the restriction element for invariant natural killer T cells (iNKT).
Xiangshu Wen +3 more
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Assessing the response of T cells to "Mycobacterium tuberculosis" lipids [PDF]
, 2008 Most vaccines used nowadays are created using inactivated or attenuated compounds from micro-organisms. Advances in basic immunology and molecular biology opened the gate for consequent improvement of vaccination strategies.
Collmann, Anthony
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Activation mechanisms of invariant natural killer T cells (iNKTs)
Iatreia, 2016 A great amount of knowledge on natural killer T cells (iNKTs) is now available, but a consensus about their activation mechanisms has not been reached. These cells recognize different glycolipid antigens through the CD1d molecule.
Baena, Andrés +2 more
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Ex Vivo Expansion of Th2-Polarizing Immunotherapeutic iNKT Cells from Human Peripheral Blood
, 2021 iNKT cells, classified as innate lymphocytes with invariant TCRs, have been highlighted as a putative, “off-the-shelf” cellular immunotherapeutic strategy for the treatment of malignant and nonmalignant diseases.
Kelly J. Andrews +5 more
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Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells
Nature Communications, 2020 Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental ...
S. Harsha Krovi +6 more
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Unraveling Natural Killer T-Cells Development
Frontiers in Immunology, 2018 Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT) cell ...
Sabrina Bianca Bennstein
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Tissue-specific functions of invariant natural killer T cells [PDF]
Nature Reviews Immunology, 2018 Invariant natural killer T cells (iNKT cells) are an innate-like T cell subset that expresses an invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They secrete diverse cytokines and can influence many types of immune responses.
Catherine M. Crosby, Mitchell Kronenberg
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The role of coronin 1 during cell mediated immune responses [PDF]
, 2013 Coronin 1 is one of 7 mammalian isoforms member of the evolutionary conserved WD40-repeat proteins that are involved in a variety of activities such a cell migration and cytokinesis.
Tchang, Vincent Sam Yong
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