Results 41 to 50 of about 75,921 (210)

Peripheral blood invariant natural killer T cells of pig-tailed macaques. [PDF]

PLoS ONE, 2012
In humans, invariant natural killer T (iNKT) cells represent a small but significant population of peripheral blood mononuclear cells (PBMCs) with a high degree of variability.
Xiangming Li, Patricia Polacino, Raquel Garcia-Navarro, Shiu-Lok Hu, Moriya Tsuji   +4 more
doaj   +1 more source

Invariant natural killer T cells as sensors and managers of inflammation.

Trends in Immunology, 2013
L. Van Kaer, Vrajesh V. Parekh, Lan Wu
semanticscholar   +3 more sources

Adipose invariant natural killer T cells [PDF]

Immunology, 2014
SummaryAdipose tissue is a dynamic organ that makes up a substantial proportion of the body; in severe obesity it can account for 50% of body mass. Details of the unique immune system resident in human and murine adipose tissue are only recently emerging, and so it has remained a largely unexplored and unappreciated immune site until now.
openaire   +2 more sources

Invariant natural killer T cells: bridging innate and adaptive immunity [PDF]

Cell and Tissue Research, 2010
Cells of the innate immune system interact with pathogens via conserved pattern-recognition receptors, whereas cells of the adaptive immune system recognize pathogens through diverse, antigen-specific receptors that are generated by somatic DNA rearrangement. Invariant natural killer T (iNKT) cells are a subset of lymphocytes that bridge the innate and
L. Kaer, Vrajesh V. Parekh, Lan Wu
semanticscholar   +3 more sources

Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential [PDF]

, 2016
Ajudes rebudes: Marie Curie Career Integration Grant; Dexeus Foundation for Women's Health Research; i Contratos Ramón y CajalCD11c is an α integrin classically employed to define myeloid dendritic cells.
A Arakelyan, Annie Rodolosse, Antoni Tarrats, B Ljutic, C Sadhu, CC Denucci, CE Egan, D Fujiwara, D Ganguly, DC Bullard, DI Godfrey, DJ Pennington, DL Farber, DM Williams, E Billerbeck, E Gonzalez-Roca, GK Smyth, J Del Campo, Jamal Qualai, JC Grivel, JD Haas, JJ Moon, JM Fuller, Jon Cantero, JR Fergusson, JW Huleatt, K Kubota, LA Cooney, Lauro Sumoy, Lin-Xi Li, LS Cauley, LX Li, M Beyer, M Brandes, M Eberl, M Kuka, M Roederer, Marco Antonio Fernández, Meritxell Genescà, N Lycke, NA Bezman, OS Qureshi, PA Romagnoli, R. Keith Reeves, RT Trifonova, S Paul, S Tsai, SM Tan, Stephen J. McSorley, T Vorup-Jensen, YH Kim, Z Chen   +51 more
core   +9 more sources

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells [PDF]

, 2014
Invariant natural killer T (iNKT) cells are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled iNKT cell gene expression during ontogeny and in peripheral subsets as part ...
Brennan, Patrick J., Brenner, Michael B., Brigl, Manfred, Cohen, Nadia R., Kang, Joonsoo, Shay, Tal, Watts, Gerald F.   +6 more
core   +5 more sources

Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy

Haematologica, 2013
Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell ...
Robert Weinkove, Collin R. Brooks, John M. Carter, Ian F. Hermans, Franca Ronchese   +4 more
doaj   +1 more source

Synthesis of C-5" and C-6"-modified α-GalCer analogues as iNKT-cell agonists [PDF]

, 2015
Alpha-Galactosyl Ceramide (α-GalCer) is a prototypical synthetic ligand of invariant natural killer T (iNKT) cells. Upon presentation by the MHC class I-like molecule CD1d, this glycolipid stimulates iNKT cells to secrete a vast amount of both pro ...
ASPESLAGH, SANDRINE, Elewaut, Dirk, Guillaume, Joren, Pauwels, Nora, Van Calenbergh, Serge, Zajonc, Dirk   +5 more
core   +1 more source

Galactosylsphingamides : new α-GalCer analogues to probe the F’-pocket of CD1d [PDF]

, 2017
Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic alpha-galactosylceramide, they produce a vast amount of cytokines.
Decruy, Tine, Elewaut, Dirk, Froeyen, Mathy, Guillaume, Joren, Janssens, Jonas, Remesh, Soumya G, Risseeuw, Martijn, Van Calenbergh, Serge, Wang, Jing, Zajonc, Dirk M   +9 more
core   +1 more source

Invariant NKT cells and rheumatic disease: Focus on primary sjogren syndrome [PDF]

, 2019
Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology.
Barbera L. L., Ciccia F., Guggino G., Pizzo M. L., Rizzo C., Sireci G.   +5 more
core   +1 more source