Results 41 to 50 of about 13,860 (111)

Enhancing Neuroblastoma Immunotherapies by Engaging iNKT and NK Cells

Frontiers in Immunology, 2020
Neuroblastoma (NB) is the most common extracranial solid tumor in children and, in the high-risk group, has a 5-year mortality rate of ~50%. The high mortality rate and significant treatment-related morbidities associated with current standard of care ...
Kevin O. McNerney, Spyridon A. Karageorgos, Spyridon A. Karageorgos, Michael D. Hogarty, Hamid Bassiri   +4 more
doaj   +1 more source

Dual-targeted CAR T-cell immunotherapies for hematological malignancies: latest updates from the 2023 ASH annual meeting

Experimental Hematology & Oncology
Over the past few years, dual-targeted chimeric antigen receptor (CAR) T-cell therapy has been employed in the management of hematological malignancies to mitigate treatment failure, particularly in cases of antigen escape.
Jingyi Yang, Hao Guo, Lu Han, Yongping Song, Keshu Zhou   +4 more
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Development of Unconventional T Cells Controlled by MicroRNA

Frontiers in Immunology, 2019
Post-transcriptional gene regulation through microRNA (miRNA) has emerged as a major control mechanism of multiple biological processes, including development and function of T cells. T cells are vital components of the immune system, with conventional T
Samantha J. Winter, Andreas Krueger
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Role of CD1d- and MR1-Restricted T Cells in Asthma

Frontiers in Immunology, 2018
Innate T lymphocytes are a group of relatively recently identified T cells that are not involved in either innate or adaptive immunity. Unlike conventional T cells, most innate T lymphocytes express invariant T cell receptor to recognize exogenous non ...
Chiaki Iwamura, Toshinori Nakayama
doaj   +1 more source

TCR signal strength controls thymic differentiation of iNKT cell subsets

Nature Communications, 2018
Invariant natural killer T (iNKT) cells can be subsetted by their cytokine profiles, but how they develop in the thymus is unclear. Here the authors show, by analysing mice carrying mutant Zap70 genes, that T cell receptor signaling strength induces ...
Kathryn D. Tuttle, S. Harsha Krovi, Jingjing Zhang, Romain Bedel, Laura Harmacek, Lisa K. Peterson, Leonard L. Dragone, Adam Lefferts, Catherine Halluszczak, Kent Riemondy, Jay R. Hesselberth, Anjana Rao, Brian P. O’Connor, Philippa Marrack, James Scott-Browne, Laurent Gapin   +15 more
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Generation of Human iNKT Cell Lines

Bio-Protocol, 2013
Natural killer T (NKT) cells comprise an important immunoregulatory T cell subset and express cell surface proteins characteristic of both natural killer cells and T cells.
Xiangming Li, Moriya Tsuji, Jonathan Schneck, Tonya Webb   +3 more
doaj   +1 more source

Breakthrough for Anticancer Immunotherapy: Current Advances in Manufacturing Protocols of Chimeric Antigen Receptor-Based Therapies

Antibodies
Chimeric antigen receptor (CAR)-based immunotherapy has emerged as a transformative strategy in anticancer treatment, driven by advances in CAR construct design, manufacturing platforms, and expansion to diverse immune cell types. The landmark success of
Yuxin Qian, Weiwei Ma, Xiao-Ning Xu
doaj   +1 more source

How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets

Frontiers in Immunology, 2018
In contrast to peptide-recognizing T cells, invariant natural killer T (iNKT) cells express a semi-invariant T cell receptor that specifically recognizes self- or foreign-lipids presented by CD1d molecules.
Haiguang Wang, Kristin A. Hogquist
doaj   +1 more source

High Activation of γδ T Cells and the γδ2pos T-Cell Subset Is Associated With the Onset of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, ANRS 12153 CAPRI NK

Frontiers in Immunology, 2019
Background: Human Immunodeficiency Virus 1 (HIV-1) and Mycobacterium Tuberculosis (Mtb) co-infected patients are commonly at risk of immune reconstitution inflammatory syndrome (IRIS) when initiating antiretroviral treatment (ART).
Polidy Pean, Janin Nouhin, Meng Ratana, Yoann Madec, Laurence Borand, Olivier Marcy, Didier Laureillard, Marcelo Fernandez, Françoise Barré-Sinoussi, Laurence Weiss, Laurence Weiss, Daniel Scott-Algara   +11 more
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Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23

Nature Communications, 2018
Invariant Natural Killer T cells (iNKT) rapidly exert effector functions upon activation, but the mechanisms of their functional maturation remain to be determined.
Yu Xu, Yang Sun, Hao Shen, Yuling Dai, Haifeng Liu, Ronghong Li, Hongdao Zhang, Ligang Wu, Xiaoyan Zhu, Xiaolong Liu   +9 more
doaj   +1 more source